o,o-diethyl phosphorothionate profile

O,O-diethyl phosphorothionate: metabolite of organothiophosphorous insecticides; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

O,O-diethyl hydrogen thiophosphate : An organic thiophosphate that is the diethyl ester of phosphorothioic O,O,O-acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	655
CHEMBL ID	1232328
CHEBI ID	28006
SCHEMBL ID	466088
MeSH ID	M0123325

Synonym
CHEMBL1232328
chebi:28006 ,
o,o-diethyl s-hydrogen phosphorothioate
o,o-diethyl phosphorothionate
nsc289411
nsc-289407
nsc289404
nsc-289183
nsc289403
nsc-289427
nsc289407
nsc-289404
nsc-289411
nsc-289403
C06607
diethylthiophosphoric acid
DPJ ,
o,o-diethyl hydrogen thiophosphate
DB07674
o,o-diethyl hydrogen phosphorothioate
AKOS006278530
depth
phosphorothioic acid, o,o-diethyl ester
diethyl phosphothionate
fnd2adq374 ,
ethyl phosphorothioate ((eto)2(hs)po)
o,o-diethyl phosphorothiolate
diethyl hydrogen phosphorothionate
detp (ester)
2465-65-8
diethyl phosphorothionate
unii-fnd2adq374
DTXSID9052844
diethyl phos-phorothioate
SCHEMBL466088
diethoxy(sulfanylidene)phosphinous acid
diethylthiophosphorate
bdbm50487243
diethoxy-hydroxy-sulfanylidene-lambda5-phosphane
Q26840832
ethyl phosphorothioate
phosphorthioic acid o,o-diethyl ester

Excerpt	Relevance	Reference
" Urinary DETP concentrations were sensitive indicators of diazinon exposure and provided quantitative differences between small, large, and acute dosage exposures."	( Diagnostic value of urinary dialkyl phosphate measurement in goats exposed to diazinon. Mount, ME, 1984)	0.27
" On a group basis, there was no statistically significant mean depression in plasma or erythrocyte cholinesterase when compared with pre-exposure levels for either dosing experiment."	( Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses. Cocker, J; Garfitt, SJ; Jones, K; Mason, HJ, 2002)	0.31

Role	Description
human xenobiotic metabolite	Any human metabolite produced by metabolism of a xenobiotic compound in humans.
mouse metabolite	Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
organic thiophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Acetylcholinesterase	Drosophila melanogaster (fruit fly)	IC50 (µMol)	40,000.0000	1.8300	1.8300	1.8300	AID1092102
Carboxylic ester hydrolase	Musca domestica (house fly)	IC50 (µMol)	25,000.0000	0.0008	4.7554	9.5100	AID1092101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID1092101	Inhibition of acetylcholinesterase in Musca domestica (house fly) brain by Ellman's method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Homo- and hetero-dimers of inactive organophosphorous group binding at dual sites of AChE.
AID1092102	Inhibition of acetylcholinesterase in Drosophila melanogaster brain by Ellman's method	2011	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21	Homo- and hetero-dimers of inactive organophosphorous group binding at dual sites of AChE.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (14.29)	18.7374
1990's	2 (9.52)	18.2507
2000's	6 (28.57)	29.6817
2010's	5 (23.81)	24.3611
2020's	5 (23.81)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.55%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (95.45%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	3.23	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
diethyl phosphate diethyl phosphate: RN given refers to parent cpd. diethyl hydrogen phosphate : A dialkyl phosphate having ethyl as the alkyl group.	3.1	5	dialkyl phosphate	human xenobiotic metabolite; mouse metabolite
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	4.08	4	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
coumaphos Coumaphos: A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as a nematocide.	2.05	1	organic thiophosphate; organochlorine compound; organothiophosphate insecticide	acaricide; agrochemical; antinematodal drug; avicide; EC 3.1.1.8 (cholinesterase) inhibitor
diazinon Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.	2.89	4	organic thiophosphate; pyrimidines	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; nematicide; xenobiotic
ethion ethion: minor descriptor (73-82); online & Index Medicus search INSECTICIDES, ORGANOTHIOPHOSPHATE (73-82). ethion : An organic thiophosphate that is S,S'-methanediyl bis[dihydrogen (phosphorodithioate)] in which all the hydroxy groups have been converted to their corresponding ethyl esters respectively. Ethion is an organophosphate insecticide with inhibitory activity towards the enzyme acetylcholinesterase ( EC 3.1.1.7).	2.08	1	organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; environmental contaminant; insecticide
malathion Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.	3.01	2	diester; ethyl ester; organic thiophosphate
phosalone phosalone: structure. phosalone : A member of the class of 1,3-benzoxazoles carrying a [(diethoxyphosphorothioyl)sulfanyl]methyl group at the nitrogen atom, an oxo group at position 2 and a chloro group at position 6. It is an organothiophosphate insecticide.	1.98	1	1,3-benzoxazoles; carbamate ester; organochlorine insecticide; organothiophosphate insecticide	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2.15	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
triiodothyronine Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.. 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism.	2.15	1	2-halophenol; amino acid zwitterion; iodophenol; iodothyronine	human metabolite; mouse metabolite; thyroid hormone
o,o-diethyl dithiophosphate O,O-diethyl dithiophosphate: structure given in first source	2.4	2	organic thiophosphate
dimethyl phosphate dimethyl phosphate: excreted in urine after exposure to mevinphos; RN given refers to parent cpd; structure	2.15	1	dialkyl phosphate
3-phenoxybenzoic acid 3-phenoxybenzoic acid: metabolite associated with exposure to pyrethroid insecticides. 3-phenoxybenzoic acid : A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides.	3.01	2	phenoxybenzoic acid	human xenobiotic metabolite; marine xenobiotic metabolite
3,5,6-trichloro-2-pyridinol 3,5,6-trichloro-2-pyridinol: RN given refers to parent cpd. 3,5,6-trichloropyridine-2-one : A pyridone that is pyridin-2(1H)-one substituted by chloro groups at positions 3, 5 and 6. It is a metabolite of the agrochemical chlorpyrifos.. 3,5,6-trichloro-2-pyridinol : A hydroxypyridine that is pyridin-2-ol substituted by chloro groups at positions 3,5 and 6. It is a metabolite of the agrochemical chlorpyrifos.	3.23	1	chloropyridine; hydroxypyridine; pyridone	human urinary metabolite; human xenobiotic metabolite; marine xenobiotic metabolite
terbufos [no description available]	2.6	1	organic thiophosphate; organosulfur compound; organothiophosphate insecticide	agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
glucuronic acid Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.	2.45	2	D-glucuronic acid	algal metabolite
thiophosphoric acid thiophosphoric acid: RN given refers to parent cpd	2.41	1	phosphorothioic acid
o,o-dimethyl phosphorothionate O,O-dimethyl phosphorothionate: metabolite of phosmet; RN given refers to parent cpd	2.7	3	organic thiophosphate
o,o-dimethyl phosphorodithioate O,O-dimethyl phosphorodithioate: metabolite of phosmet; RN given refers to parent cpd	2.82	3
chlorferron chlorferron: metabolite of coumaphos	2.45	2	organochlorine compound

Condition	Relationship Strength	Studies
Overweight A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.	2.6	1
Leanness [description not available]	2.6	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.6	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.41	2
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	1.98	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1
Cognition Disorders Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.	1.97	1
Developmental Psychomotor Disorders [description not available]	1.97	1

o,o-diethyl phosphorothionate

Description

Cross-References

Synonyms (42)

Research Excerpts

Dosage Studied

Roles (2)

Drug Classes (1)

Protein Targets (2)

Inhibition Measurements

Bioassays (2)

Research

Studies (21)

Market Indicators

Research Demand Index: 11.75

Study Types