Compounds > tyramine o-sulfate
Page last updated: 2024-11-07

tyramine o-sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

tyramine O-sulfate: sulfate conjugated tyramine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

tyramine sulfate : An aryl sulfate that is tyramine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID153005
CHEMBL ID4764181
CHEBI ID125571
CHEBI ID133530
SCHEMBL ID18560960
MeSH IDM0090414

Synonyms (24)

Synonym
tyramine o-sulfate
tyramine sulfate
tyramine o-sulphate
4-(2-aminoethyl)phenyl hydrogen sulfate
30223-92-8
CHEBI:125571
[4-(2-aminoethyl)phenyl]oxidanesulfonic acid
CHEBI:133530
[4-(2-aminoethyl)phenyl] hydrogen sulfate
phenol, 4-(2-aminoethyl)-, hydrogen sulfate (ester)
sia20bp28w ,
unii-sia20bp28w
phenol, 4-(2-aminoethyl)-, 1-(hydrogen sulfate)
phenol, p-(2-aminoethyl)-, hydrogen sulfate (ester)
phenol, p-(2-aminoethyl)-, hydrogen sulfate
BRD-K49808142-001-01-1
Q27216185
tyramine-o-sulfate
DTXSID50184324
SCHEMBL18560960
4-(2-aminoethyl)-phenol(hydrogen sulphate)
4-(2-aminoethyl)-phenol(hydrogen sulfate)
DB14630
CHEMBL4764181
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
human xenobiotic metaboliteAny human metabolite produced by metabolism of a xenobiotic compound in humans.
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
human xenobiotic metaboliteAny human metabolite produced by metabolism of a xenobiotic compound in humans.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
aryl sulfate
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
aryl sulfate
zwitterionA neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1698625Toxicity in ddY mouse assessed as motor suppression at 23 nmol, icv measured for 60 mins2020Journal of natural products, 10-23, Volume: 83, Issue:10
Diverse Aromatic Metabolites in the Solitary Tunicate
AID1698623Toxicity in ddY mouse assessed as death of organism at 92 nmol, icv measured for 60 mins2020Journal of natural products, 10-23, Volume: 83, Issue:10
Diverse Aromatic Metabolites in the Solitary Tunicate
AID1698640Induction of metamorphosis in Catocala irene at 10 ug/ml measured up to 84 hrs2020Journal of natural products, 10-23, Volume: 83, Issue:10
Diverse Aromatic Metabolites in the Solitary Tunicate
AID1698622Toxicity in ddY mouse assessed as violent convulsions at 92 nmol, icv measured for 60 mins2020Journal of natural products, 10-23, Volume: 83, Issue:10
Diverse Aromatic Metabolites in the Solitary Tunicate
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.71 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index10.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (17.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxyphenylacetic acid
4-hydroxyphenylacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group.		1.9510monocarboxylic acid;
phenols		fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite
tyramine
[no description available]		2.8840monoamine molecular messenger;
primary amino compound;
tyramines		EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter
tyrosine
Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.		1.9710amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.2510glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
tyrosine o-sulfate
O(4')-sulfo-L-tyrosine : An O-sulfoamino acid that is L-tyrosine in which the phenolic hydrogen has been replaced by a sulfo group.		1.9710aryl sulfate;
L-tyrosine derivative;
O-sulfoamino acid		human metabolite
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		1.9510cysteiniumfundamental metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Affective Psychosis, Bipolar
[description not available]		02.3720
Depression, Endogenous
[description not available]		02.3720
Bipolar Disorder
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.		02.3720
Depressive Disorder
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.		02.3720
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.		01.9510
Hepatocellular Carcinoma
[description not available]		01.9710
Cancer of Liver
[description not available]		01.9710
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		01.9710
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9710