dimethyldiselenide profile

Dimethyl diselenide (DMDS) is an organoselenium compound with the formula (CH3)2Se2. It is a colorless liquid with a pungent odor. DMDS is a versatile reagent used in organic synthesis, and it is also a potential source of selenium in the diet. DMDS is synthesized by reacting methyl lithium with selenium. The synthesis of DMDS is important because it provides a starting point for the synthesis of other organoselenium compounds, which are used in a variety of applications, including pharmaceuticals, agrochemicals, and materials science. DMDS has been shown to have antioxidant and anti-inflammatory properties, and it may also have anticancer activity. However, DMDS is toxic and should be handled with care. Studies on DMDS focus on its role in the synthesis of other selenium compounds, its biological activity, and its potential environmental impact.'
```

dimethyldiselenide: volatile selenium metabolite [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dimethyl diselenide : An organoselenium compound that is diselane covalently bound to two methyl groups. It has been detected in onion-family vegetables and soft-necked garlics. It induces ER stress and toxic protein aggregation in the budding yeast, S. cerevisiae and used as a reagent to identify distonic radical cations. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	23496
CHEBI ID	176517
MeSH ID	M0113336

Synonym
1,2-dimethyldiselane
diselenide, dimethyl
CHEBI:176517
diselenobismethane
(methyldiselanyl)methane
dimethyldiselane
dimethyldiselenide
AKOS015840122
methyl diselenide
(ch3se)2
dimethyl diselenide, 96%
7101-31-7
dimethyl diselenide
D3290
A837049
ah7tj8228u ,
einecs 230-410-7
unii-ah7tj8228u
FT-0625133
DTXSID40221237
1,2-dimethyldiselane #
mfcd00008254
H10908
methyl diselenide, 8ci
AMY31938
SY048201
CS-0199215
diselane, 1,2-dimethyl-

Excerpt	Relevance	Reference
" We investigated the metabolism of L-selenomethionine (SeMet) and selenite by probiotic bacteria in vitro and the disposition of selenium after probiotic treatment followed by oral dosing with SeMet and selenite in rats."	( Metabolism of L-selenomethionine and selenite by probiotic bacteria: in vitro and in vivo studies. Fawcett, JP; Krittaphol, W; McDowell, A; Tagg, JR; Thomson, CD; Wescombe, PA, 2011)	0.37

Role	Description
bacterial metabolite	Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
mammalian metabolite	Any animal metabolite produced during a metabolic reaction in mammals.
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
human xenobiotic metabolite	Any human metabolite produced by metabolism of a xenobiotic compound in humans.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
organoselenium compound	An organoselenium compound is a compound containing at least one carbon-selenium bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
superpathway of seleno-compound metabolism	3	39
seleno-amino acid detoxification and volatilization III	2	6
superpathway of seleno-compound metabolism	7	44

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (50.00)	29.6817
2010's	6 (37.50)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen selenide hydrogen selenide: RN given refers to parent cpd	2.07	1	mononuclear parent hydride; selenium hydride	Escherichia coli metabolite; mouse metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.79	3	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	2.02	1	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
selenic acid Selenic Acid: A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.	2.03	1	selenium oxoacid
selenious acid Selenious Acid: A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.	1.96	1	selenium oxoacid
dimethylselenide dimethylselenide: RN given refers to unlabeled cpd. dimethylselenide : An organoselenium compound of two methyl groups covalently bound to a selenium.	4.04	14	organoselenium compound	bacterial xenobiotic metabolite; plant metabolite
selenomethionine [no description available]	7.92	4	selenoamino acid; selenomethionines	plant metabolite
selenocystine selenocystine: RN given refers to parent cpd; structure	1.96	1	diselenide; selenoamino acid
sodium selenite disodium selenite : An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.	2.96	4	inorganic sodium salt; selenite salt	nutraceutical
selenomethylselenocysteine selenomethylselenocysteine: RN given refers to parent cpd	2	1	non-proteinogenic alpha-amino acid; selenocysteines	antineoplastic agent; human metabolite
methylselenic acid methylseleninic acid : An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.	2.42	2	one-carbon compound; organoselenium compound	antineoplastic agent; EC 3.5.1.98 (histone deacetylase) inhibitor; human xenobiotic metabolite
cystine [no description available]	1.96	1
sodium borohydride sodium borohydride: RN given refers to parent cpd	2.05	1	inorganic sodium salt; metal tetrahydridoborate
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	7	1	cysteinium	fundamental metabolite
selenium Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	2.39	2	chalcogen; nonmetal atom	micronutrient
selenocysteine Selenocysteine: A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid.. selenocysteine : An alpha-amino acid that consists of alanine where one of the methyl hydrogens is substituted with a seleno group.	7	1
methaneselenol methaneselenol: RN given refers to (75)Se-labeled cpd. methylselenol : An organoselenium compound that is a selenium analogue of methanol, comprising a methyl group covalently bound to a selenol group.	2.79	3

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.44	2	0

dimethyldiselenide

Description

Cross-References

Synonyms (28)

Research Excerpts

Dosage Studied

Roles (4)

Drug Classes (1)

Pathways (2)

Research

Studies (16)

Market Indicators

Research Demand Index: 29.30

Study Types