The role played by a molecular entity, such as an atom or free radical, which is involved in chain-propagating reactions.
ChEBI ID: 53431
| Member | Definition | Class |
|---|---|---|
| acenaphthenequinone | An orthoquinone that is the 1,2-dioxo derivative of acenaphthene. | acenaphthoquinone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 35.5452 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 6.1600 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 37.6505 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 23.3789 | 2 | 2 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 25.7951 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 20.5962 | 1 | 1 |
| Ataxin-2 | Homo sapiens (human) | Potency | 27.2783 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 27.2783 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 68.5199 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 68.5199 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 4.1541 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 2.2334 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.0355 | 4 | 5 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 43.2331 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 17.8523 | 4 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 5.4587 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.8166 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 54.4273 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 21.8564 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 112.9350 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.2512 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 3.1623 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 32.4201 | 3 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 54.4273 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.2783 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 13.9390 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 11.1210 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 2.8184 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 0.6159 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 25.8659 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 20.6680 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 54.4273 | 1 | 1 |
| Vpr | Human immunodeficiency virus 1 | Potency | 8.9125 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Homo sapiens (human) | Ki | 100.0000 | 2 | 2 |
| Cholinesterase | Homo sapiens (human) | Ki | 21.2282 | 3 | 5 |
| Coagulation factor XII | Homo sapiens (human) | Ki | 1.0570 | 1 | 3 |
| Cocaine esterase | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | IC50 | 1,425.0000 | 1 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | Ki | 57.0000 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 0.6466 | 3 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | Kd | 324.1420 | 1 | 2 |