thalidomide has been researched along with Granulomatosis, Orofacial in 3 studies
Thalidomide: A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
thalidomide : A racemate comprising equimolar amounts of R- and S-thalidomide.
2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione : A dicarboximide that is isoindole-1,3(2H)-dione in which the hydrogen attached to the nitrogen is substituted by a 2,6-dioxopiperidin-3-yl group.
Granulomatosis, Orofacial: A condition characterized by persistent or recurrent labial enlargement, ORAL ULCER, and other orofacial manifestations in the absence of identifiable CROHN DISEASE; or SARCOIDOSIS. Among experts there is disagreement on whether orofacial granulomatosis is a distinct clinical disorder or an initial presentation of Crohn disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thalidomide was effective in inducing remission of oral and intestinal symptoms in all five cases and could be considered a valid treatment opportunity for these patients." | 1.42 | Orofacial granulomatosis in children: think about Crohn's disease. ( Bersanini, C; Cont, G; Fontana, M; Lazzerini, M; Martelossi, S; Taddio, A; Ventura, A; Ventura, G; Zuin, G, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kaushik, A | 1 |
| Raj, D | 1 |
| Chatterjee, D | 1 |
| Vinay, K | 1 |
| Eustace, K | 1 |
| Clowry, J | 1 |
| Kirby, B | 1 |
| Lally, A | 1 |
| Lazzerini, M | 1 |
| Martelossi, S | 1 |
| Cont, G | 1 |
| Bersanini, C | 1 |
| Ventura, G | 1 |
| Fontana, M | 1 |
| Zuin, G | 1 |
| Ventura, A | 1 |
| Taddio, A | 1 |
3 other studies available for thalidomide and Granulomatosis, Orofacial
| Article | Year |
|---|---|
Apremilast in orofacial granulomatosis-A report of five cases.
Topics: Crohn Disease; Granulomatosis, Orofacial; Humans; Thalidomide | 2020 |
Thalidomide in the treatment of refractory orofacial granulomatosis.
Topics: Adult; Drug Resistance; Granulomatosis, Orofacial; Humans; Immunosuppressive Agents; Male; Thalidomi | 2014 |
Orofacial granulomatosis in children: think about Crohn's disease.
Topics: Adolescent; Biopsy; Child; Colonoscopy; Crohn Disease; Diagnosis, Differential; Female; Granulomatos | 2015 |