Page last updated: 2024-12-05
2,3-dimethylsuccinic acid
Description
2,3-dimethylsuccinic acid, also known as 2,3-dimethylbutanedioic acid, is a dicarboxylic acid with the formula HO2CCH(CH3)CH(CH3)CO2H. It is a white crystalline solid that is soluble in water. 2,3-dimethylsuccinic acid is a chiral compound, and there are two enantiomers: (R,R)-2,3-dimethylsuccinic acid and (S,S)-2,3-dimethylsuccinic acid. 2,3-dimethylsuccinic acid is often studied in the context of organic chemistry and biochemistry, as it is a model compound for understanding the properties and reactions of dicarboxylic acids. It is also of interest in the field of materials science, as it can be used to synthesize polymers with unique properties. The compound has been synthesized using various methods including the reaction of α-bromoisobutyric acid with diethyl malonate followed by hydrolysis and decarboxylation. 2,3-dimethylsuccinic acid has been shown to have anti-inflammatory activity in animal models. It is also being investigated for its potential use in treating cancer. The study of 2,3-dimethylsuccinic acid is driven by its potential applications in various fields such as medicine, materials science, and organic chemistry. '
2,3-dimethylsuccinic acid: RN given refers to cpd with specified locants for methyl moieties [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
2,3-dimethylsuccinic acid : An alpha,omega-dicarboxylic acid that is succinic acid substituted by two methyl groups at positions 2 and 3 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 11848 |
| CHEBI ID | 167506 |
| SCHEMBL ID | 83830 |
| MeSH ID | M0104710 |
Synonyms (48)
| Synonym |
|---|
| einecs 210-163-1 |
| (r*,s*)-2,3-dimethylsuccinic acid |
| nsc 400523 |
| BB 0262731 |
| CHEBI:167506 |
| 608-39-9 |
| 2,3-dimethylbutanedioic acid |
| (-)-2,3-dimethylbutanedioic acid |
| racemic-2,3-dimethyl-butanedioic acid |
| (-)-2,3-dimethylsuccinic acid |
| meso-2,3-dimethyl-butanedioic acid |
| 2,3-butanedicarboxylic acid |
| 2,3-dimethylsuccinic acid |
| succinic acid,3-dimethyl- |
| nsc41215 |
| butanedioic acid,3-dimethyl- |
| 13545-04-5 |
| nsc-41215 |
| .alpha.,.beta.-dimethylsuccinic acid |
| nsc400523 |
| succinic acid,3-dimethyl-, erythro-meso- |
| succinic acid,3-dimethyl-, meso- |
| butanedioic acid,3-dimethyl-, [r-(r*,s*)]- |
| erythro-2,3-dimethylsuccinic acid |
| butanedioic acid,3-dimethyl-, (r*,s*)- |
| nsc-400523 |
| inchi=1/c6h10o4/c1-3(5(7)8)4(2)6(9)10/h3-4h,1-2h3,(h,7,8)(h,9,10 |
| 2,3-dimethylsuccinic acid, >=99% |
| F3732904-C1E2-4B5F-BB1B-954B2582E062 |
| succinic acid, 2,3-dimethyl- |
| 57694-62-9 |
| AKOS006223731 |
| butanedioic acid,2,3-dimethyl- |
| nsc 41215 |
| butanedioic acid, 2,3-dimethyl- |
| einecs 236-915-9 |
| FT-0632534 |
| SCHEMBL83830 |
| 2,3-dimethyl succinic acid |
| J-006701 |
| FT-0716862 |
| DTXSID40871958 |
| F83083 |
| 2,3-dimethylsuccinicacid |
| SB47808 |
| CS-0217793 |
| EN300-85056 |
| Z1205493640 |
Roles (1)
| Role | Description |
|---|
| chelator | A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Drug Classes (1)
| Class | Description |
|---|
| alpha,omega-dicarboxylic acid | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 21.94
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 21.94 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.59 (4.65) | | Search Engine Demand Index | 18.60 (26.88) | | Search Engine Supply Index | 2.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 1 (16.67%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (83.33%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |