brl 44408 has been researched along with clonidine in 24 studies
| Studies (brl 44408) | Trials (brl 44408) | Recent Studies (post-2010) (brl 44408) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 82 | 0 | 16 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | brl 44408 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 17 (70.83) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gleason, MM; Hieble, JP | 1 |
| Chou, B; Green, PG; Khasar, SG; Levine, JD | 1 |
| Mateo, Y; Meana, JJ | 1 |
| Altobelli, D; Martire, M; Maurizi, S; Preziosi, P | 1 |
| de Vries, J; Kawahara, Y; Pudovkina, OL; Westerink, BH | 1 |
| De Kock, M; Eisenach, JC; Lavand'homme, PM; Ma, W | 1 |
| Cremers, TI; Pudovkina, OL; Westerink, BH | 1 |
| Eisenach, JC; Lavand'homme, PM | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Fernández-Pastor, B; Gómez-Urquijo, S; Javier Meana, J; Mateo, Y | 1 |
| Ebersberger, A; Mikulik, O; Richter, F; Schaible, HG | 1 |
| Bexis, S; Docherty, JR | 1 |
| Eisenach, JC; Romero-Sandoval, A | 1 |
| Centurión, D; Gupta, S; Jiménez-Mena, LR; Lozano-Cuenca, J; MaassenVanDenBrink, A; Mehrotra, S; Muñoz-Islas, E; Sánchez-López, A; Villalón, CM | 1 |
| Eisenach, JC; Liu, B | 1 |
| Centurión, D; Görnemann, T; Jähnichen, S; Kleuser, B; Pertz, HH; Villalón, CM; von Wenckstern, H | 1 |
| Benvenuti, E; Fang, Y; Ferrie, A; Hong, Y; Lai, F; Lui, L; Miret, J; Nettleton, D; Posner, B; Potchoiba, M; Webb, B; Wielis, C | 1 |
| Dunkel, P; Fülöp, K; Gyires, K; Shujaa, N; Zádori, ZS | 1 |
| Albarrán-Juárez, JA; Centurión, D; Görnemann, T; Lozano-Cuenca, J; Pertz, HH; Villalón, CM | 1 |
| Elsworth, JD; Jentsch, JD; Roth, RH; Sanchez, D | 1 |
| Dukat, M; Scheinin, M; Vainio, M; Young, S | 1 |
| Alfredson, H; Andersson, G; Backman, LJ; Danielson, P; Fong, G; Scott, A | 1 |
| Al-Khrasani, M; Fehér, Á; Gyires, K; Hein, L; Helyes, Z; Holzer, P; Kozsurek, M; Puskár, Z; Tábi, T; Timár, J; Tóth, VE; Zádori, ZS | 1 |
| Endo, S; Kozawa, M; Murakami, H; Muto, M; Tadano, T; Tan-No, K; Tsuchiya, M; Yaoita, F | 1 |
24 other study(ies) available for brl 44408 and clonidine
| Article | Year |
|---|---|
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cells, Cultured; Clonidine; Cricetinae; Dibenzazepines; Imidazoles; Indoles; Isoindoles; Lung; Mice; Neuroblastoma; Neurons; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha; Tritium; Tumor Cells, Cultured; Yohimbine | 1991 |
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcimycin; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Pain Measurement; Peripheral Nervous System; Quinoxalines; Rats; Rats, Sprague-Dawley; Yohimbine | 1995 |
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors | 1999 |
Interaction of formamidine pesticides with the presynaptic alpha(2)-adrenoceptor regulating.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Chlorphenamidine; Clonidine; Dose-Response Relationship, Drug; Female; Hypothalamus; Imidazoles; Indoles; Insecticides; Isoindoles; Norepinephrine; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Synaptosomes; Toluidines; Tritium; Xylazine; Yohimbine | 2001 |
The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Calcium; Clonidine; Environment, Controlled; Extracellular Space; GABA Antagonists; Imidazoles; Indoles; Isoindoles; Isotonic Solutions; Locus Coeruleus; Male; Microdialysis; Neural Pathways; Neurons; Norepinephrine; Piperazines; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Ringer's Solution; Serotonin Receptor Agonists; Stress, Physiological; Tetrodotoxin | 2001 |
Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Cyclic AMP Response Element-Binding Protein; Imidazoles; Immunohistochemistry; Indoles; Isoindoles; Male; Microscopy, Confocal; Neuronal Plasticity; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Wistar; Sciatic Nerve; Spinal Cord | 2002 |
Regulation of the release of serotonin in the dorsal raphe nucleus by alpha1 and alpha2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Imidazoles; Indoles; Isoindoles; Male; Neurons; Pons; Prazosin; Prefrontal Cortex; Raphe Nuclei; Rats; Rats, Wistar; Reaction Time; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Serotonin | 2003 |
Perioperative administration of the alpha2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Cytokines; Drug Combinations; Hyperalgesia; Imidazoles; Indoles; Interleukin-1; Intraoperative Care; Isoindoles; Ligation; Male; Motor Activity; Pain Threshold; Physical Stimulation; Postoperative Care; Preoperative Care; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sciatic Nerve; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha; Wounds and Injuries | 2003 |
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Learning; Brain; Clonidine; Dose-Response Relationship, Drug; Electroshock; Fear; Guanabenz; Imidazoles; Indoles; Injections, Intraperitoneal; Isoindoles; Male; Mental Recall; Mice; Motor Activity; Motor Skills; Reaction Time; Receptors, Adrenergic, alpha-2; Yohimbine | 2004 |
Characterization of noradrenaline release in the locus coeruleus of freely moving awake rats by in vivo microdialysis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Cerebrospinal Fluid; Clonidine; Dialysis Solutions; Extracellular Fluid; Imidazoles; Indoles; Isoindoles; Locus Coeruleus; Male; Microdialysis; Motor Activity; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reserpine; Synaptic Vesicles; Tetrodotoxin; Wakefulness | 2005 |
Noradrenergic agonists and antagonists influence migration of cortical spreading depression in rat-a possible mechanism of migraine prophylaxis and prevention of postischemic neuronal damage.
Topics: Adrenergic alpha-Agonists; Adrenergic Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Brain Damage, Chronic; Brain Ischemia; Cerebral Cortex; Cerebrovascular Circulation; Clonidine; Cortical Spreading Depression; Drug Interactions; Electrodes, Implanted; Imidazoles; Indoles; Isoindoles; Male; Migraine Disorders; Norepinephrine; Piperazines; Propranolol; Rats; Rats, Wistar; Serotonin 5-HT1 Receptor Antagonists | 2005 |
Role of alpha2A-adrenoceptors in the effects of MDMA on body temperature in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Body Temperature; Clonidine; Fever; Hallucinogens; Imidazoles; Indoles; Isoindoles; Male; Mice; Mice, Knockout; N-Methyl-3,4-methylenedioxyamphetamine; Receptors, Adrenergic, alpha-2; Serotonin Agents | 2005 |
Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Cytokines; Imidazoles; Indoles; Injections; Isoindoles; Ligation; Male; Pain; Pain Threshold; Physical Stimulation; Rats; Rats, Wistar; Sciatic Nerve; Sciatic Neuropathy | 2006 |
Clonidine inhibits the canine external carotid vasodilatation to capsaicin by alpha2A/2C-adrenoceptors.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Carotid Artery, External; Clonidine; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Indoles; Isoindoles; Male; Phenylephrine; Quinolizines; Receptors, Adrenergic, alpha-2; Reproducibility of Results; Vasodilation; Yohimbine | 2006 |
Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cell Count; Clonidine; Enzyme Activation; Gene Expression Regulation; Imidazoles; Immunohistochemistry; Indoles; Isoindoles; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Rats; Reaction Time; Sciatic Neuropathy; Sensory Thresholds | 2006 |
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Gene Expression; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Neuromuscular Junction; Norepinephrine; Piperazines; Prazosin; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Vasoconstriction; Yohimbine | 2007 |
Multiplexing G protein-coupled receptors in microarrays: a radioligand-binding assay.
Topics: Adrenergic alpha-Antagonists; Animals; Cell Line; Clonidine; Cricetinae; Humans; Imidazoles; Indoles; Isoindoles; Isoquinolines; Piperazines; Protein Array Analysis; Protein Binding; Radioligand Assay; Receptors, Adrenergic; Receptors, G-Protein-Coupled | 2007 |
Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Gastrointestinal Motility; Hypoglycemic Agents; Imidazoles; Insulin; Isoindoles; Male; Muscarinic Agonists; Muscle Contraction; Oxymetazoline; Prazosin; Rats; Rats, Wistar; Receptors, Presynaptic; Stomach; Synapses | 2007 |
Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Imidazoles; In Vitro Techniques; Isoindoles; Male; Neurons, Afferent; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 2008 |
Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Clonidine; Disease Models, Animal; Dopamine; Guanfacine; Imidazoles; Isoindoles; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Schizophrenia | 2008 |
Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Clonidine; Drug Synergism; Guanidines; Imidazoles; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Receptors, Adrenergic, alpha; Tail; Yohimbine | 2010 |
Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: Comparison between two model systems.
Topics: Achilles Tendon; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Cell Proliferation; Cells, Cultured; Clonidine; Cumulative Trauma Disorders; Disease Models, Animal; Female; Humans; Imidazoles; In Vitro Techniques; Isoindoles; Rabbits; Receptors, Adrenergic, alpha-2; Tendinopathy; Tyrosine 3-Monooxygenase | 2013 |
Inhibition of α2A-Adrenoceptors Ameliorates Dextran Sulfate Sodium-Induced Acute Intestinal Inflammation in Mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Colitis; Dextran Sulfate; Drinking; Female; Gene Knockout Techniques; Imidazoles; Intestinal Mucosa; Intestines; Isoindoles; Locomotion; Male; Mice; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2 | 2016 |
Involvement of peripheral alpha2A adrenoceptor in the acceleration of gastrointestinal transit and abdominal visceral pain induced by intermittent deprivation of REM sleep.
Topics: Acetic Acid; Acridines; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Transit; Ileum; Imidazoles; Irritable Bowel Syndrome; Isoindoles; Male; Mice; Piperazines; Receptors, Adrenergic; Sleep Deprivation; Sleep, REM; Visceral Pain | 2018 |