brl 44408 has been researched along with yohimbine in 23 studies
| Studies (brl 44408) | Trials (brl 44408) | Recent Studies (post-2010) (brl 44408) | Studies (yohimbine) | Trials (yohimbine) | Recent Studies (post-2010) (yohimbine) |
|---|---|---|---|---|---|
| 82 | 0 | 16 | 5,893 | 253 | 532 |
| Protein | Taxonomy | brl 44408 (IC50) | yohimbine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.02 | |
| D(2) dopamine receptor | Homo sapiens (human) | 2.06 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0428 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0466 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.126 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.013 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.126 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.074 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.689 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (26.09) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neubig, RR; Porter, AC; Uhlén, S | 1 |
| Biagini, P; Biancalani, C; Cesari, N; Dal Piaz, V; Galeotti, N; Ghelardini, C; Giovannoni, MP; Graziano, A; Vergelli, C | 1 |
| Gleason, MM; Hieble, JP | 1 |
| Chou, B; Green, PG; Khasar, SG; Levine, JD | 1 |
| Falkay, G; Kovács, L | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Coupar, IM; Liu, L | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 2 |
| Altobelli, D; Martire, M; Maurizi, S; Preziosi, P | 1 |
| Cleary, L; Docherty, JR; Vandeputte, C | 1 |
| Arulmani, U; Centurión, D; Saxena, PR; Valdivia, LF; Villalón, CM | 1 |
| Lodge, NJ; Myers, RA; Plym, MJ; Signor, LJ | 1 |
| Hernádi, I; Kovács, P | 1 |
| Centurión, D; Gupta, S; Jiménez-Mena, LR; Lozano-Cuenca, J; MaassenVanDenBrink, A; Mehrotra, S; Muñoz-Islas, E; Sánchez-López, A; Villalón, CM | 1 |
| Centurión, D; Görnemann, T; Jähnichen, S; Kleuser, B; Pertz, HH; Villalón, CM; von Wenckstern, H | 1 |
| Albarrán-Juárez, JA; Centurión, D; Görnemann, T; Lozano-Cuenca, J; Pertz, HH; Villalón, CM | 1 |
| Imaki, J; Mae, Y; Ohno, Y; Shimizu, S | 1 |
| Calasans-Maia, JA; Galdino, SL; Hernandes, MZ; Lima, MC; Pitta, IR; Sudo, RT; Zapata-Sudo, G | 1 |
| Dukat, M; Scheinin, M; Vainio, M; Young, S | 1 |
| Centurión, D; Hofmann, RA; Jantschak, F; Pertz, HH; Popp, AM; Villalón, CM | 1 |
| Hernádi, I; Tóth, M; Uzsoki, B | 1 |
| Bult, H; De Meyer, GR; Fransen, P; Martinet, W; Schrijvers, DM; Van Hove, CE; van Langen, JT | 1 |
23 other study(ies) available for brl 44408 and yohimbine
| Article | Year |
|---|---|
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dibenzazepines; Humans; Imidazoles; Indoles; Isoindoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action.
Topics: Abdominal Muscles; Abdominal Pain; Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Cerebral Cortex; Norepinephrine; Pyridazines; Rats; Selective Serotonin Reuptake Inhibitors; Structure-Activity Relationship; Synaptosomes; Yohimbine | 2006 |
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cells, Cultured; Clonidine; Cricetinae; Dibenzazepines; Imidazoles; Indoles; Isoindoles; Lung; Mice; Neuroblastoma; Neurons; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha; Tritium; Tumor Cells, Cultured; Yohimbine | 1991 |
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcimycin; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Pain Measurement; Peripheral Nervous System; Quinoxalines; Rats; Rats, Sprague-Dawley; Yohimbine | 1995 |
Expression of two alpha 2-adrenergic receptor subtypes in human placenta: evidence from direct binding studies.
Topics: Adult; Binding, Competitive; Dibenzazepines; Female; Humans; Imidazoles; Indoles; Isoindoles; Placenta; Prazosin; Pregnancy; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1994 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
Role of alpha 2-adrenoceptors in the regulation of intestinal water transport.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biological Transport; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; Ileum; Imidazoles; Indoles; Intestinal Absorption; Isoindoles; Isoquinolines; Jejunum; Male; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vasoactive Intestinal Peptide; Water; Yohimbine | 1997 |
Antinociception induced by amitriptyline and imipramine is mediated by alpha2A-adrenoceptors.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Antidepressive Agents, Tricyclic; Dose-Response Relationship, Drug; Imidazoles; Imipramine; Indoles; Isoindoles; Male; Mice; Naloxone; Organophosphorus Compounds; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
Interaction of formamidine pesticides with the presynaptic alpha(2)-adrenoceptor regulating.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Chlorphenamidine; Clonidine; Dose-Response Relationship, Drug; Female; Hypothalamus; Imidazoles; Indoles; Insecticides; Isoindoles; Norepinephrine; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Synaptosomes; Toluidines; Tritium; Xylazine; Yohimbine | 2001 |
Investigation of postjunctional alpha1- and alpha2-adrenoceptor subtypes in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Cocaine; Electric Stimulation; Imidazoles; Indoles; Isoindoles; Isometric Contraction; Male; Mice; Mice, Knockout; Nifedipine; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic; Suramin; Thymine; Vas Deferens; Yohimbine | 2003 |
5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Carotid Artery, External; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Ergotamine; Hypotension; Imidazoles; Indoles; Injections, Intravenous; Isoindoles; Male; Piperazines; Piperidones; Prazosin; Quinolizines; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha; Regional Blood Flow; Spiro Compounds; Sympathectomy; Vagotomy; Vasoconstriction; Yohimbine | 2004 |
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Learning; Brain; Clonidine; Dose-Response Relationship, Drug; Electroshock; Fear; Guanabenz; Imidazoles; Indoles; Injections, Intraperitoneal; Isoindoles; Male; Mental Recall; Mice; Motor Activity; Motor Skills; Reaction Time; Receptors, Adrenergic, alpha-2; Yohimbine | 2004 |
1-(2-pyrimidinyl)-piperazine, a buspirone metabolite, modulates bladder function in the anesthetized rat.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; ATP-Binding Cassette Transporters; Benzhydryl Compounds; Buspirone; Cresols; Cromakalim; Dose-Response Relationship, Drug; Female; Imidazoles; Indoles; Isoindoles; KATP Channels; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Phenylpropanolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolterodine Tartrate; Urinary Bladder; Urodynamics; Yohimbine | 2004 |
Yohimbine acts as a putative in vivo alpha2A/D-antagonist in the rat prefrontal cortex.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Animals; Drug Antagonism; Guanfacine; Imidazoles; Indoles; Iontophoresis; Isoindoles; Male; Prefrontal Cortex; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Yohimbine | 2006 |
Clonidine inhibits the canine external carotid vasodilatation to capsaicin by alpha2A/2C-adrenoceptors.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Carotid Artery, External; Clonidine; Dogs; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Indoles; Isoindoles; Male; Phenylephrine; Quinolizines; Receptors, Adrenergic, alpha-2; Reproducibility of Results; Vasodilation; Yohimbine | 2006 |
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Gene Expression; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Neuromuscular Junction; Norepinephrine; Piperazines; Prazosin; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Vasoconstriction; Yohimbine | 2007 |
Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with alpha(2A/2C)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Imidazoles; In Vitro Techniques; Isoindoles; Male; Neurons, Afferent; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 2008 |
Therapeutic potential of alpha2 adrenoceptor antagonism for antipsychotic-induced extrapyramidal motor disorders.
Topics: Acridines; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antipsychotic Agents; Catalepsy; Dose-Response Relationship, Drug; Haloperidol; Hypokinesia; Imidazoles; Isoindoles; Male; Mice; Motor Activity; Piperazines; Yohimbine | 2009 |
Interaction of morphine with a new alpha2-adrenoceptor agonist in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Imidazoles; Imidazolidines; Isoindoles; Male; Mice; Models, Molecular; Morphine; Pain; Random Allocation; Receptors, Adrenergic, alpha-2; Yohimbine | 2010 |
Antinociceptive synergism of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Behavior, Animal; Clonidine; Drug Synergism; Guanidines; Imidazoles; Injections, Subcutaneous; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Pain; Pain Measurement; Receptors, Adrenergic, alpha; Tail; Yohimbine | 2010 |
Postjunctional α2C-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Imidazoles; In Vitro Techniques; Isoindoles; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Piperazines; Prazosin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin; Tail; Temperature; Vasoconstriction; Yohimbine | 2010 |
Novelty response of rats determines the effect of prefrontal alpha-2 adrenoceptor modulation on anxiety.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Guanfacine; Imidazoles; Individuality; Isoindoles; Male; Maze Learning; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 2011 |
Contribution of α-adrenoceptor stimulation by phenylephrine to basal nitric oxide production in the isolated mouse aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dose-Response Relationship, Drug; Imidazoles; Isoindoles; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Vasoconstrictor Agents; Yohimbine | 2013 |