Compounds > anatoxin a
Page last updated: 2024-09-02

anatoxin a and epibatidine

anatoxin a has been researched along with epibatidine in 7 studies

Compound Research Comparison

Studies
(anatoxin a)		Trials
(anatoxin a)		Recent Studies (post-2010)
(anatoxin a)		Studies
(epibatidine)		Trials
(epibatidine)		Recent Studies (post-2010) (epibatidine)
522012670013
52201265930115

Protein Interaction Comparison

ProteinTaxonomyanatoxin a (IC50)epibatidine (IC50)
Acetylcholine receptor subunit alphaHomo sapiens (human)0.16
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.0011
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)0.43
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)0.031
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.0011

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's6 (85.71)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dart, MJ; Holladay, MW; Lynch, JK1
Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Wegge, T1
Gallagher, T; Karig, G; Millar, NS; Sharples, CG; Simpson, GL; Spencer, JA; Wonnacott, S; Wright, E1
Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Weber, A; Wegge, T1
Cécyre, D; Drouin, M; Lan, R; Lejeune, H; Quirion, R; Villeneuve, G1
Collins, AC; Gallagher, T; Kaiser, S; Marks, MJ; Sharples, CG; Soliakov, L; Spencer, JA; Washburn, M; Whiteaker, P; Wonnacott, S; Wright, E1
Jones, IW; Pullar, IA; Rousseau, SJ; Wonnacott, S1

Reviews

1 review(s) available for anatoxin a and epibatidine

ArticleYear
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship

1997

Other Studies

6 other study(ies) available for anatoxin a and epibatidine

ArticleYear
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
    Journal of medicinal chemistry, 2002, Feb-28, Volume: 45, Issue:5

    Topics: Adrenal Glands; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; In Vitro Techniques; Ligands; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Swine

2002
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.
    Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Bridged-Ring Compounds; Cell Line; Ligands; Molecular Conformation; Monte Carlo Method; Neurons; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2002
3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.
    Journal of medicinal chemistry, 2003, May-22, Volume: 46, Issue:11

    Topics: Alkaloids; Animals; Azocines; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cyanobacteria Toxins; Drug Design; In Vitro Techniques; Ligands; Marine Toxins; Microcystins; Models, Molecular; Prosencephalon; Protein Subunits; Pyridines; Quantitative Structure-Activity Relationship; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tropanes

2003
Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.
    Bioorganic & medicinal chemistry letters, 2003, Nov-03, Volume: 13, Issue:21

    Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bungarotoxins; Drug Design; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Mimicry; Neurons; Prosencephalon; Quinolizines; Radioligand Assay; Rats; Receptors, Nicotinic; Structure-Activity Relationship

2003
UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cells, Cultured; Conotoxins; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Humans; Marine Toxins; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Synaptosomes; Tropanes; Xenopus

2000
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.
    Neuropharmacology, 2005, Volume: 49, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes

2005