Page last updated: 2024-09-02

anatoxin a and nicotine

anatoxin a has been researched along with nicotine in 23 studies

Compound Research Comparison

Studies
(anatoxin a)
Trials
(anatoxin a)
Recent Studies (post-2010)
(anatoxin a)
Studies
(nicotine)
Trials
(nicotine)
Recent Studies (post-2010) (nicotine)
522012628,5192,2809,302
60128,5192,2809,302

Protein Interaction Comparison

ProteinTaxonomyanatoxin a (IC50)nicotine (IC50)
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)0.0055
Acetylcholine receptor subunit alphaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit betaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit gammaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit deltaTetronarce californica (Pacific electric ray)0.0025
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.3256
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)0.005
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)4
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)0.43
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)0.1866
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)7.6
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)0.0041
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.3456
Neuronal acetylcholine receptor subunit alpha-7Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-3Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)0.0087
Neuronal acetylcholine receptor subunit alpha-6Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-5Mus musculus (house mouse)0.004
Liver carboxylesterase B-1Rattus norvegicus (Norway rat)0.045
Neuronal acetylcholine receptor subunit beta-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-4Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-6Mus musculus (house mouse)0.004

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19903 (13.04)18.7374
1990's12 (52.17)18.2507
2000's6 (26.09)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Abood, LG; Kanne, DB1
Koskinen, AM; Rapoport, H1
Dart, MJ; Holladay, MW; Lynch, JK1
Gohlke, H; Gündisch, D; Schwarz, S; Seitz, G; Tilotta, MC; Wegge, T1
Akireddy, S; Bhatti, BS; Gatto, GJ; Hammond, P; Hauser, TA; Jordan, KG; Kombo, D; Mazurov, AA; Miao, L; Miller, CH; Murthy, S; Speake, JD; Strachan, JP; Xiao, YD; Yohannes, D; Zhang, J1
Brown, ND; Chiang, PK; Doctor, BP; Gordon, RK; Katzhendler, J1
Albuquerque, EX; Garcha, HS; Stolerman, IP1
Feuerstein, G; Sirén, AL1
Rowell, PP; Wonnacott, S1
Albuquerque, EX; Lunt, GG; Macallan, DR; Rapoport, H; Swanson, KL; Wonnacott, S1
Brough, PA; Gallagher, T; Livett, BG; Molloy, L; Wonnacott, S1
Albuquerque, EX; Alkondon, M; Lindstrom, J; Maelicke, A; Peng, X; Pereira, EF; Reinhardt, S; Whiting, P1
Amar, M; Johnson, C; Lunt, GG; Thomas, P; Wonnacott, S1
Nordberg, A; Zhang, X1
Albuquerque, EX; Alkondon, M; Amar, M; Gallagher, T; Lunt, GG; Pereira, E; Stephens, M; Thomas, P; Whiting, P; Wilkie, G1
Clarke, PB; Reuben, M1
Everett, DJ; Fawell, JK; Hill, RE; Mitchell, RE1
Collins, AC; Gallagher, T; Kaiser, S; Marks, MJ; Sharples, CG; Soliakov, L; Spencer, JA; Washburn, M; Whiteaker, P; Wonnacott, S; Wright, E1
Akaike, N; Katsurabayashi, S; Kiyosawa, A; Pang, ZP1
Jones, IW; Pullar, IA; Rousseau, SJ; Wonnacott, S1
Barik, J; Wonnacott, S1
Farmer, JD; Jarema, KA; MacPhail, RC1
Fasoli, F; Gotti, C; Novelli, F; Sparatore, F; Tasso, B1

Reviews

1 review(s) available for anatoxin a and nicotine

ArticleYear
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.
    Journal of medicinal chemistry, 1997, Dec-19, Volume: 40, Issue:26

    Topics: Acetylcholine; Animals; Binding Sites; Dopamine; Drug Design; Humans; Molecular Structure; Nervous System; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship

1997

Other Studies

22 other study(ies) available for anatoxin a and nicotine

ArticleYear
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Animals; Brain; Carbachol; Electric Organ; Ganglionic Stimulants; In Vitro Techniques; Nicotine; Pyridines; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Torpedo; Tropanes

1988
Synthetic and conformational studies on anatoxin-a: a potent acetylcholine agonist.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Bacterial Toxins; Chemical Phenomena; Chemistry; Chemistry, Physical; Computers; Crystallization; Cyanobacteria Toxins; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Marine Toxins; Microcystins; Molecular Conformation; Receptors, Cholinergic; Solutions; Tropanes; X-Ray Diffraction

1985
Synthesis and nicotinic binding studies on enantiopure diazine analogues of the novel (2-chloro-5-pyridyl)-9-azabicyclo[4.2.1]non-2-ene UB-165.
    Journal of medicinal chemistry, 2002, Feb-28, Volume: 45, Issue:5

    Topics: Adrenal Glands; Animals; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; In Vitro Techniques; Ligands; Nicotinic Agonists; Pyrazines; Pyridazines; Pyridines; Pyrimidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship; Swine

2002
Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.
    Journal of medicinal chemistry, 2012, Nov-08, Volume: 55, Issue:21

    Topics: Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cognition Disorders; Cricetinae; Cricetulus; Exploratory Behavior; Humans; Male; Models, Molecular; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship

2012
Postganglionic nicotinic action of anatoxin-a on guinea pig ileum antagonized by thymopentin.
    Advances in experimental medicine and biology, 1992, Volume: 311

    Topics: Amino Acid Sequence; Animals; Bacterial Toxins; Choline; Cyanobacteria; Cyanobacteria Toxins; Guinea Pigs; Hemicholinium 3; Ileum; In Vitro Techniques; Marine Toxins; Microcystins; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Nicotine; Parasympathomimetics; Thymopentin; Tropanes

1992
Behavioural effects of anatoxin, a potent nicotinic agonist, in rats.
    Neuropharmacology, 1992, Volume: 31, Issue:3

    Topics: Animals; Bacterial Toxins; Behavior, Animal; Cyanobacteria Toxins; Discrimination, Psychological; Ganglionic Stimulants; Male; Marine Toxins; Mecamylamine; Microcystins; Motor Activity; Nicotine; Rats; Tropanes

1992
Cardiovascular effects of anatoxin-A in the conscious rat.
    Toxicology and applied pharmacology, 1990, Volume: 102, Issue:1

    Topics: Animals; Bacterial Toxins; Cardiac Output; Cardiovascular Physiological Phenomena; Cardiovascular System; Catecholamines; Cyanobacteria; Cyanobacteria Toxins; Hindlimb; Injections, Intraventricular; Male; Marine Toxins; Microcystins; Nicotine; Rats; Rats, Inbred Strains; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Tropanes; Vascular Resistance; Wakefulness

1990
Evidence for functional activity of up-regulated nicotine binding sites in rat striatal synaptosomes.
    Journal of neurochemistry, 1990, Volume: 55, Issue:6

    Topics: Animals; Bacterial Toxins; Binding Sites; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Male; Marine Toxins; Microcystins; Nicotine; Potassium; Rats; Rats, Inbred Strains; Synaptosomes; Tropanes; Up-Regulation

1990
Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems.
    FEBS letters, 1988, Jan-04, Volume: 226, Issue:2

    Topics: Aconitine; Aconitum; Animals; Bacterial Toxins; Binding, Competitive; Brain; Bungarotoxins; Cyanobacteria Toxins; Ganglia; Grasshoppers; Kinetics; Marine Toxins; Microcystins; Nicotine; Rats; Receptors, Nicotinic; Species Specificity; Tropanes

1988
Anatoxin-a is a potent agonist of the nicotinic acetylcholine receptor of bovine adrenal chromaffin cells.
    European journal of pharmacology, 1995, May-26, Volume: 289, Issue:3

    Topics: Animals; Bacterial Toxins; Cattle; Cells, Cultured; Chromaffin System; Cyanobacteria Toxins; Epinephrine; Marine Toxins; Mecamylamine; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Norepinephrine; Potassium; Tropanes

1995
Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 270, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Bacterial Toxins; Binding Sites; Cells, Cultured; Chickens; Cyanobacteria Toxins; Dexamethasone; Dose-Response Relationship, Drug; Fibroblasts; Galantamine; Kinetics; Marine Toxins; Membrane Potentials; Microcystins; Molecular Probes; Neurons; Nicotine; Physostigmine; Receptors, Nicotinic; Recombinant Proteins; Tropanes

1994
Agonist pharmacology of the neuronal alpha 7 nicotinic receptor expressed in Xenopus oocytes.
    FEBS letters, 1993, Aug-02, Volume: 327, Issue:3

    Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bacterial Toxins; Cyanobacteria Toxins; Dimethylphenylpiperazinium Iodide; DNA; Marine Toxins; Membrane Potentials; Microcystins; Neurons; Nicotine; Oocytes; Piperazines; Quaternary Ammonium Compounds; Quinolizines; Receptors, Nicotinic; Tropanes; Xenopus

1993
The competition of (-)-[3H]nicotine binding by the enantiomers of nicotine, nornicotine and anatoxin-a in membranes and solubilized preparations of different brain regions of rat.
    Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 348, Issue:1

    Topics: Animals; Bacterial Toxins; Binding, Competitive; Brain; Cyanobacteria Toxins; In Vitro Techniques; Male; Marine Toxins; Microcystins; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereoisomerism; Tropanes

1993
(+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors.
    Journal of neurochemistry, 1993, Volume: 60, Issue:6

    Topics: Acetylcholine; Animals; Bacterial Toxins; Chickens; Choline; Cyanobacteria Toxins; Hippocampus; Marine Toxins; Mice; Microcystins; Neurons; Nicotine; Oocytes; Rats; Receptors, Nicotinic; Recombinant Proteins; Rubidium; Synaptosomes; Transfection; Tropanes; Xenopus

1993
Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release.
    British journal of pharmacology, 1996, Volume: 117, Issue:4

    Topics: Acetylcholine; Alkaloids; Animals; Azocines; Bacterial Toxins; Citalopram; Corpus Striatum; Cyanobacteria Toxins; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Microcystins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Potassium; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Antagonists; Synaptosomes; Tetrodotoxin; Tritium; Tropanes

1996
The toxicity of cyanobacterial toxins in the mouse: II anatoxin-a.
    Human & experimental toxicology, 1999, Volume: 18, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Bacterial Toxins; Behavior, Animal; Central Nervous System; Chickens; Cyanobacteria Toxins; Drug Evaluation, Preclinical; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Marine Toxins; Mice; Microcystins; Muscle Contraction; Neck Muscles; Nicotine; No-Observed-Adverse-Effect Level; Phrenic Nerve; Pregnancy; Psychomotor Performance; Rats; Toxicity Tests; Tropanes

1999
UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Apr-15, Volume: 20, Issue:8

    Topics: Animals; Bacterial Toxins; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cells, Cultured; Conotoxins; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Humans; Marine Toxins; Microcystins; Neurotoxins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic; Synaptosomes; Tropanes; Xenopus

2000
Nicotine facilitates glycine release in the rat spinal dorsal horn.
    The Journal of physiology, 2001, Oct-01, Volume: 536, Issue:Pt 1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Bacterial Toxins; Bicuculline; Bungarotoxins; Calcium; Calcium Channels; Choline; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Marine Toxins; Mecamylamine; Microcystins; Nerve Endings; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Nicotinic; Substantia Gelatinosa; Tetrodotoxin; Tropanes; Valine

2001
Presynaptic alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate [3H]d-aspartate release from rat frontal cortex in vitro.
    Neuropharmacology, 2005, Volume: 49, Issue:1

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Aspartic Acid; Azetidines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Choline; Cyanobacteria Toxins; Dicarboxylic Acids; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Frontal Lobe; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Mecamylamine; Microcystins; Microscopy, Confocal; Neurotransmitter Uptake Inhibitors; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphopyruvate Hydratase; Potassium Chloride; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium; Tropanes

2005
Indirect modulation by alpha7 nicotinic acetylcholine receptors of noradrenaline release in rat hippocampal slices: interaction with glutamate and GABA systems and effect of nicotine withdrawal.
    Molecular pharmacology, 2006, Volume: 69, Issue:2

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bacterial Toxins; Biological Transport; Conotoxins; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Male; Marine Toxins; Microcystins; Neurons; Nicotine; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Nicotinic; Substance Withdrawal Syndrome; Tetrodotoxin; Tropanes

2006
Effects of acute and weekly episodic exposures to anatoxin-a on the motor activity of rats: comparison with nicotine.
    Toxicology, 2007, May-05, Volume: 234, Issue:1-2

    Topics: Animals; Cyanobacteria Toxins; Dose-Response Relationship, Drug; Drug Tolerance; Ganglionic Stimulants; Injections, Subcutaneous; Male; Motor Activity; Nicotine; Nicotinic Agonists; Rats; Rats, Long-Evans; Stereoisomerism; Time Factors; Tropanes

2007
(+)-Laburnamine, a natural selective ligand and partial agonist for the α4β2 nicotinic receptor subtype.
    Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

    Topics: Alkaloids; Animals; Binding, Competitive; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Humans; Italy; Ligands; Neostriatum; Nicotine; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Seeds; Stereoisomerism

2013