Target type: biologicalprocess
The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089]
Short-term memory, also known as working memory, is a cognitive system that allows us to hold a small amount of information in mind for a brief period. It acts as a temporary storage and processing system, enabling us to perform tasks that require the manipulation and integration of information. This process involves several key steps:
1. **Encoding:** Incoming sensory information is transformed into a format that can be understood and processed by the brain. This can involve visual, auditory, or semantic encoding, depending on the nature of the information.
2. **Storage:** The encoded information is temporarily stored in the working memory. The capacity of working memory is limited, typically holding only a few items at a time. This limitation can be overcome by chunking, a strategy that groups individual items into meaningful units.
3. **Retrieval:** When needed, stored information is retrieved from working memory. This process can be influenced by factors such as attention, rehearsal, and interference.
4. **Manipulation:** Working memory allows us to actively manipulate and process information. This includes tasks such as mental calculations, problem-solving, and language comprehension.
5. **Maintenance:** To keep information in working memory, it requires constant attention and rehearsal. Without active maintenance, information fades away quickly.
**Neural Basis:**
Short-term memory relies on a network of brain regions, primarily within the prefrontal cortex. The prefrontal cortex plays a crucial role in attention, executive control, and working memory maintenance. Other brain regions, such as the hippocampus and parietal cortex, are also involved in encoding, storage, and retrieval processes.
**Duration and Capacity:**
The duration of short-term memory is typically around 15-30 seconds, although this can be extended through rehearsal or chunking. The capacity of working memory is limited, typically holding around 7 +/- 2 items (Miller's Law).
**Types of Short-term Memory:**
There are different types of short-term memory, including:
* **Phonological loop:** Responsible for holding and manipulating auditory information.
* **Visuospatial sketchpad:** Holds and manipulates visual and spatial information.
* **Episodic buffer:** Integrates information from different sources, allowing for the formation of coherent memories.
**Importance:**
Short-term memory is essential for many cognitive functions, including language comprehension, problem-solving, decision-making, and learning. It allows us to hold information in mind long enough to process it, make connections, and ultimately, form new memories.
**Disruptions:**
Disruptions to short-term memory can occur due to various factors, such as:
* **Brain injury:** Damage to the prefrontal cortex or other relevant brain regions can impair working memory.
* **Attention-deficit/hyperactivity disorder (ADHD):** Individuals with ADHD often have difficulty with working memory, leading to problems with focus, organization, and task completion.
* **Stress and anxiety:** High levels of stress can negatively affect working memory by interfering with attention and cognitive processing.
Understanding the process of short-term memory is crucial for gaining insight into how we learn, remember, and interact with the world around us.'
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Protein | Definition | Taxonomy |
---|---|---|
Neuronal acetylcholine receptor subunit alpha-7 | A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36544] | Homo sapiens (human) |
Solute carrier family 2, facilitated glucose transporter member 4 | A solute carrier family 2, facilitated glucose transporter member 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14672] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
nornicotine | nornicotine: agricultural or horticultural insecticide; RN given refers to (+-)-isomer; structure | ||
bupropion | bupropion : An aromatic ketone that is propiophenone carrying a tert-butylamino group at position 2 and a chloro substituent at position 3 on the phenyl ring. Bupropion: A propiophenone-derived antidepressant and antismoking agent that inhibits the uptake of DOPAMINE. | aromatic ketone; monochlorobenzenes; secondary amino compound | antidepressant; environmental contaminant; xenobiotic |
3-(1-methylpyrrolidin-2-yl)pyridine | 3-(1-methylpyrrolidin-2-yl)pyridine : An N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. | N-alkylpyrrolidine; pyridine alkaloid; pyrrolidine alkaloid | |
epibatidine | alkaloid | ||
dimethylphenylpiperazinium iodide | piperazines | ||
1,3-dipropyl-8-(4-sulfophenyl)xanthine | 1,3-dipropyl-8-(4-sulfophenyl)xanthine: adenosine receptor antagonist | ||
anabasine | piperidine alkaloid; pyridine alkaloid | nicotinic acetylcholine receptor agonist; plant metabolite; teratogenic agent | |
carbamylcholine | |||
isoflurane | Isoflurane: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. | organofluorine compound | inhalation anaesthetic |
kynurenic acid | kynurenic acid : A quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. Kynurenic Acid: A broad-spectrum excitatory amino acid antagonist used as a research tool. | monohydroxyquinoline; quinolinemonocarboxylic acid | G-protein-coupled receptor agonist; human metabolite; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist; Saccharomyces cerevisiae metabolite |
mecamylamine | Mecamylamine: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. | primary aliphatic amine | |
n-methylcarbamylcholine | N-methylcarbamylcholine: structure given in first source | ||
sb 206553 | SB 206553: a high-affinity 5-HT(2C/2B) antagonist; structure given in first source | pyrroloindole | |
tilorone | tilorone : A member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. Tilorone: An antiviral agent used as its hydrochloride. It is the first recognized synthetic, low-molecular-weight compound that is an orally active interferon inducer, and is also reported to have antineoplastic and anti-inflammatory actions. | aromatic ether; diether; fluoren-9-ones; tertiary amino compound | anti-inflammatory agent; antineoplastic agent; antiviral agent; interferon inducer; nicotinic acetylcholine receptor agonist |
tetramethylammonium | tetramethylammonium : The simplest quaternary ammonium cation, comprising a central nitrogen linked to four methyl groups. tetramethylammonium: RN given refers to parent cpd | quaternary ammonium ion | |
boldine | aporphine alkaloid | ||
cytisine | alkaloid; bridged compound; lactam; organic heterotricyclic compound; secondary amino compound | nicotinic acetylcholine receptor agonist; phytotoxin; plant metabolite | |
anatabine | anatabine: alkaloid found in tobacco; structure | bipyridines | |
laudanosine | laudanosine: opium alkaloid | isoquinolines | |
5-hydroxyindole | hydroxyindoles | human metabolite | |
dihydro-beta-erythroidine | dihydro-beta-erythroidine : An organic heterotetracyclic compound resulting from the partial hydrogenation of the 1,3-diene moiety of beta-erythroidine to give the corresponding 2-ene. Dihydro-beta-Erythroidine: Dihydro analog of beta-erythroidine, which is isolated from the seeds and other plant parts of Erythrina sp. Leguminosae. It is an alkaloid with curarimimetic properties. | delta-lactone; organic heterotetracyclic compound; tertiary amino compound | nicotinic antagonist |
polygodial | aldehyde | ||
nicotine | (S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum. | 3-(1-methylpyrrolidin-2-yl)pyridine | anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic |
lobeline | (-)-lobeline : An optically active piperidine alkaloid having a 2-oxo-2-phenylethyl substituent at the 2-position and a 2-hydroxy-2-phenylethyl group at the 6-position. | aromatic ketone; piperidine alkaloid; tertiary amine | nicotinic acetylcholine receptor agonist |
thiacloprid | (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen. thiacloprid: structure in first source | monochloropyridine; nitrile; thiazolidines | environmental contaminant; neonicotinoid insectide; xenobiotic |
3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole | 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole: structure in first source | ||
erysodine | erysodine : An erythrina alkaloid with formula C18H21NO3 isolated from several erythrina plant species. It is a competitive antagonist of nicotinic acetylcholine receptors and exhibits antiparasitic and insecticidal activities. erysodine: structure given in first source | aromatic ether; diether; Erythrina alkaloid; organic heterotetracyclic compound; phenols | antiparasitic agent; nicotinic antagonist; phytogenic insecticide |
varenicline | varenicline : An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking. Varenicline: A benzazepine derivative that functions as an ALPHA4-BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION. | ||
pozanicline | |||
pnu 120596 | 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea: an alpha7nAChR agonist; structure in first source | ureas | |
harmicine | harmicine: structure in first source | ||
bisabolol | Kamillosan: drug combination containing chamomile and bisabolol; used to treat dermatitis | sesquiterpenoid | |
deformylflustrabromine | deformylflustrabromine: has antineoplastic activity; isolated from Flustra folicea; structure in first source | tryptamines | |
tropacocaine | tropacocaine: RN given refers to (exo)-isomer; structure | ||
isoliquiritigenin | chalcones | antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist | |
tropisetron | tropisetron : An indolyl carboxylate ester obtained by formal condensation of the carboxy group of indole-3-carboxylic acid with the hydroxy group of tropine. Tropisetron: An indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting. | indolyl carboxylic acid | |
epibatidine | |||
anatoxin a | anatoxin I: found mainly in ANABAENA; was indexed to cyanobacterial toxin (MARINE TOXINS). isolated from many salt-tolerant freshwater cyanobacteria | ||
abt 594 | |||
5-(6-chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-4-ene | azepine | ||
naringenin chalcone | 2',4,4',6'-tetrahydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 2' ,4, 4', and 6' respectively. naringenin chalcone: RN given refers to cpd with unspecified stereoisomer & from CA Vol 92 Form Index; RN for cpd not in Chemline 7/6/83; structure in first source | chalcones; polyphenol | anti-allergic agent; anti-inflammatory agent; metabolite |
trans-metanicotine | metanicotine: RN given refers to parent cpd with unspecified isomeric designation | ||
a 85380 | A 85380: structure given in first source; A-85380 is the S-enantiomer; A-159470 is the R-enantiomer | ||
ar-r 17779 | AR-R 17779: structure in first source | ||
3-(2,4-dimethoxybenzylidene)anabaseine | 3-(2,4-dimethoxybenzylidene)anabaseine: an alpha7nAChR nicotinic receptor agonist | dimethoxybenzene | |
cytochalasin b | cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments. Cytochalasin B: A cytotoxic member of the CYTOCHALASINS. | cytochalasin; lactam; lactone; organic heterotricyclic compound | actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor |
2,4,2'-trihydroxychalcone | 2,4,2'-trihydroxychalcone: structure in first source | ||
mg 624 | triethyl-(beta-4-stilbenoxyethyl)ammonium: inhibits alpha7 nicotinic receptors; structure in first source | ||
a 84543 | |||
azd 0328 | spiro(1-azabicyclo(2.2.2)octane-3,2'(3H)-furo(2,3-b)pyridine): AZD-0328 is the (2'R)-isomer and D-tartrate salt; an alpha7 neuronal nicotinic receptor agonist; structure in first source | ||
pnu-282987 | carbonyl compound; organohalogen compound | ||
ssr180711 | SSR180711: a selective alpha7 acetylcholine nicotinic receptor (n-AChRs) partial agonist; structure in first source | ||
ispronicline | ispronicline: a neuronal nicotinic acetylcholine receptor modulator; has antidepressant, neuroprotective, and cognitive effects; structure in first source | ||
desnitroimidacloprid | desnitroimidacloprid: a nicotinic receptor agonist; structure in first source | ||
crispine a | crispine A: pyrrolo(2,1-a)isoquinoline alkaloid from Carduus crispus; structure in first source | ||
amd 070 | mavorixafor: a derivative of AMD3100; a CXCR4 blocker | aminoquinoline | |
a 867744 | 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide: positive modulator of alpha7 nicotinic acetylcholine receptor; structure in first source | ||
a-582941 | A-582941: nicotinic acetylcholine receptor (alpha7 nAChR) agonist | ||
evp-6124 | |||
wzb117 | WZB117: structure in first source | ||
imidacloprid | (E)-imidacloprid : The E-isomer of imidacloprid. | imidacloprid; imidazolidines; monochloropyridine | environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic |
3-(4-hydroxy-2-methoxybenzylidene)anabaseine |