Cogan Syndrome

A condition consisting of inflammatory eye disease usually presenting as interstitial KERATITIS, vestibuloauditory dysfunction, and large- to medium-vessel vasculitis.

Synonym
Cogans Syndrome
Cogan's Syndrome
Cogan Syndrome

Excerpt	Reference
"Cogan's syndrome is a rare autoimmune disorder characterized by systemic vasculitis as well as eye and ear inflammation."	( Blackstone, J; Cartin, A; Currie, C; Pinette, MG; Wax, JR, 2009)
"Cogan's syndrome is a rare chronic inflammatory disorder which typically associates an ophthalmological and vestibulocochlear involvement, with a risk of systemic symptoms in 50-70% of cases."	( Garabedian, EN; Hautefort, C; Loundon, N; Marlin, S; Montchilova, M; Ulinski, T, 2009)
"Cogan's syndrome is a rare idiopathic chronic inflammatory disease of the eye and the inner ear in young adults."	( Conraads, V; Haine, S; Weyn, T, 2009)
"Cogan syndrome is a syndrome of non-syphilitic interstitial keratitis associated with vestibuloauditory deficits."	( Chakarbarty, B; Jain, R; Juneja, M, 2011)
"Cogan's syndrome is characterized by interstitial keratitis, vestibular impairment and hearing loss, commonly bilateral."	( Karakostas, E; Stratoudaki, R; Vasileiadis, I, 2012)
"Cogan's syndrome is a relatively rare inflammatory disorder presenting with a combination of ocular and vestibuloauditory symptoms."	( Knapp, C; Mukherjee, R; Shahid, FL, 2013)
"Cogan syndrome is a systemic disease manifesting interstitial keratitis, sensorineural hearing loss, tinnitus, and rotatory vertigo."	( Enya, T; Izu, A; Miyazawa, T; Nishi, H; Okada, M; Sugimoto, K; Takemura, T, 2014)
"Cogan's syndrome is a rare chronic vasculitis, characterized in its typical form by progressive sensorineural bilateral hearing loss, vestibular symptoms and non-syphilitic interstitial keratitis."	( Jančatová, D; Komínek, P; Matoušek, P; Zeleník, K, 2015)
"Cogans syndrome is a rare systemic inflammatory disease characterized by a combination of audiovestibular and ocular symptoms."	( Carlsson, PI; Hedin, E; Lyckberg, H, 2016)
"Cogan syndrome is a rare inflammatory condition that mainly affects adults and is characterised by inflammation of various ocular structures and by audiovestibular symptoms such as hearing loss and vertigo."	( Rösken, GRHJ; Stroomer, JWG; van Oosterhout, WRPJ, 2022)
"Cogan syndrome is a rare inflammatory condition that warrants a multidisciplinary approach by an ophthalmologist, neurologist, ENT-physician, and rheumatologist / immunologist for swift diagnosis and treatment with immunosuppressive medication."	( Rösken, GRHJ; Stroomer, JWG; van Oosterhout, WRPJ, 2022)

Excerpt	Reference
"A 33-year-old G1 P0 with Cogan's syndrome experienced an uneventful pregnancy while being treated with hydroxychloroquine and prednisone."	( Blackstone, J; Cartin, A; Currie, C; Pinette, MG; Wax, JR, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (3.03)	23.3326
1990's	0 (0.00)	12.5806
2000's	6 (18.18)	18.1394
2010's	23 (69.70)	28.8240
2020's	3 (9.09)	9.53

Drug	Relationship Strength	Studies
aspirin	low	2
azathioprine	low	4
hydroxychloroquine	low	1
lamotrigine	low	1
leflunomide	low	1
prednisolone	low	10
prednisone	low	2
fluprednisolone	low	1
methylprednisolone	low	8
isoxazoles	low	1
adenosine diphosphate ribose	low	1
propiconazole	low	1
dexamethasone sulfate ester	low	1
fluorodeoxyglucose f18	low	1
methotrexate	low	3
cortisone	low	1
fibrin	low	1
difluprednate	low	1
tacrolimus	low	1
mycophenolic acid	low	1
cardiovascular agents	low	2
cyclosporine	low	2
clozapine	low	1
eye	low	1

Protein Targets (466)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
TDP1 protein	13	0	0	13
Transient receptor potential cation channel subfamily M member 2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
thioredoxin reductase	7	0	0	7
GLS protein	4	0	0	4
AR protein	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
thyroid stimulating hormone receptor	2	0	0	2
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	7	0	0	7
glucocorticoid receptor [Homo sapiens]	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
estrogen-related nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	14	0	0	14
cytochrome P450 2D6	4	0	0	4
glucocerebrosidase	2	0	0	2
peroxisome proliferator-activated receptor delta	8	0	0	8
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
Bloom syndrome protein isoform 1	6	0	0	6
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	6	0	0	6
DNA polymerase kappa isoform 1	3	0	0	3
muscarinic acetylcholine receptor M1	6	0	0	6
lethal factor (plasmid)	3	0	0	3
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	9
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	10	0	10
Epidermal growth factor receptor	0	1	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	1	3
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	2	1	0	3
Myeloperoxidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	2	1	0	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	5	2	0	7
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	8	0	8
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Chain A, Ferritin light chain	5	0	0	5
acetylcholinesterase	5	0	0	5
phosphopantetheinyl transferase	4	0	0	4
RAR-related orphan receptor gamma	8	0	0	8
SMAD family member 2	3	0	0	3
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	3	0	0	3
SMAD family member 3	3	0	0	3
GLI family zinc finger 3	8	0	0	8
Microtubule-associated protein tau	3	0	0	3
thioredoxin glutathione reductase	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
retinoid X nuclear receptor alpha	7	0	0	7
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	7	0	0	7
G	4	0	0	4
polyprotein	3	0	0	3
P53	2	0	0	2
peroxisome proliferator activated receptor gamma	6	0	0	6
arylsulfatase A	2	0	0	2
aryl hydrocarbon receptor	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	10	0	0	10
thyroid stimulating hormone receptor	1	0	0	1
activating transcription factor 6	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	4	0	0	4
peripheral myelin protein 22 isoform 1	5	0	0	5
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
thyroid hormone receptor beta isoform 2	8	0	0	8
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
geminin	9	0	0	9
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	5	0	0	5
M-phase phosphoprotein 8	4	0	0	4
muscleblind-like protein 1 isoform 1	3	0	0	3
lamin isoform A-delta10	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	5	1	0	6
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Cellular tumor antigen p53	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit delta	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	5	1	0	6
Glutamate receptor 2	8	1	0	9
Gamma-aminobutyric acid receptor subunit alpha-5	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	5	1	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-3	5	1	0	6
Gamma-aminobutyric acid receptor subunit beta-2	5	1	0	6
GABA theta subunit	5	1	0	6
Inositol hexakisphosphate kinase 1	4	0	0	4
ATPase family AAA domain-containing protein 5	9	0	0	9
Ataxin-2	9	0	0	9
Gamma-aminobutyric acid receptor subunit epsilon	5	1	0	6
Protein-arginine deiminase type-4	0	3	0	3
cytochrome P450 2C9, partial	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Luciferase	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
NFKB1 protein, partial	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	10	0	0	10
Beta-1 adrenergic receptor	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
caspase-3	2	0	0	2
Adenylate cyclase type 1	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
chromobox protein homolog 1	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
DNA polymerase beta	2	0	0	2
mitogen-activated protein kinase 1	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	5	0	0	5
short transient receptor potential channel 6 isoform 1	0	0	1	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Albumin	0	0	1	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Muscarinic acetylcholine receptor M2	0	4	1	5
Muscarinic acetylcholine receptor M4	0	3	1	4
ATP-dependent translocase ABCB1	0	0	0	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Cytochrome P450 3A4	0	3	0	4
5-hydroxytryptamine receptor 1A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	3	0	4
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Calmodulin-1	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Cytochrome P450 2D6	0	0	0	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	3	1	4
Cytochrome P450 2C9	0	2	0	3
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	5
5-hydroxytryptamine receptor 2A	0	3	0	3
Alpha-1B adrenergic receptor	0	2	1	3
Alpha-2B adrenergic receptor	0	3	0	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	3	0	3
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-2B adrenergic receptor	0	2	1	3
D(2) dopamine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	3	1	4
Endothelin receptor type B	1	1	0	2
D(1A) dopamine receptor	0	2	0	3
D(4) dopamine receptor	0	2	0	4
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	1	0	1
Alpha-2C adrenergic receptor	0	2	1	3
UDP-glucuronosyltransferase 1A4	0	0	0	2
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	2	1	3
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Endothelin receptor type B	0	1	0	1
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	0	4
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
5-hydroxytryptamine receptor 1D	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	1	3
Histamine H1 receptor	0	1	1	2
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Cytochrome P450 2C19	0	0	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Histamine H1 receptor	0	2	2	6
Alpha-1B adrenergic receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	4
5-hydroxytryptamine receptor 3A	0	1	0	1
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	1	3
Alpha-1A adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 6	0	2	0	3
Cytochrome P450 2J2	0	2	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Spike glycoprotein	3	0	1	4
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Calmodulin	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
5-hydroxytryptamine receptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
5-hydroxytryptamine receptor 3D	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
D	0	2	0	2
Histamine H4 receptor	0	1	1	2
5-hydroxytryptamine receptor 3B	0	1	0	1
Transporter	0	1	0	1
Histamine H3 receptor	0	1	0	1
endonuclease IV	1	0	0	1
dopamine D1 receptor	2	0	0	2
pregnane X receptor	3	0	0	3
regulator of G-protein signaling 4	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
flap endonuclease 1	2	0	0	2
Glucocorticoid receptor	0	8	2	15
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	8	0	8
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	4	0	0	4
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, Beta-lactamase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
neuropeptide S receptor isoform A	2	0	0	2
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
GALC protein	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	7	0	0	7
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Dihydrofolate reductase	0	4	2	6
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
glp-1 receptor, partial	3	0	0	3
matrix metalloproteinase 1, partial	0	0	1	1
USP1 protein, partial	3	0	0	3
PPM1D protein	2	0	0	2
Thrombopoietin	1	0	0	1
nonstructural protein 1	3	0	0	3
Parkin	1	0	0	1
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	2	0	0	2
histone deacetylase 9 isoform 3	1	0	0	1
huntingtin isoform 2	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Endothelin-1 receptor	1	0	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
67.9K protein	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
vitamin D3 receptor isoform VDRA	3	0	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
ATP-dependent phosphofructokinase	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Androgen receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Alpha-synuclein	1	0	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
heat shock protein 90, putative	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (33)

Protein Targets (466)

Cogan Syndrome

Synonyms(3)

Research Excerpts

Overview

Treatment

Research

Studies (33)

Drugs Studied (27)

Protein Targets (466)