diafenthiuron: a pro-pesticide; inhibits mitochondrial ATPase in vitro and in vivo by its carbodiimide product [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
diafenthiuron : An aromatic ether that is 1,3-diisopropyl-5-phenoxybenzene in which the hydrogen atom at position 2 is substituted by a (tert-butylcarbamothioyl)nitrilo group. An agricultural proinsecticide which is used to control mites, aphids and whitefly in cotton. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 3034380 |
| CHEBI ID | 39299 |
| SCHEMBL ID | 27926 |
| MeSH ID | M0232139 |
| Synonym |
|---|
| n-(2,6-bis(1-methylethyl)-4-phenoxyphenyl)-n'-(1,1-dimethylethyl)thiourea |
| pegasus |
| diafenthiuron |
| 3-(2,6-diisopropyl-4-phenoxyphenyl)-1-tert-butylthiourea |
| 80060-09-9 |
| cga 106630 |
| 1-tert-butyl-3-(2,6-diisopropyl-4-phenoxyphenyl)thiourea |
| polo |
| cg 167 |
| CHEBI:39299 |
| diafenthiuron [iso] |
| 1-tert-butyl-3-(2,6-di-isopropyl-4-phenoxyphenyl)thiourea |
| thiourea, n-(2,6-bis(1-methylethyl)-4-phenoxyphenyl)-n'-(1,1-dimethylethyl)- |
| pegasus (pesticide) |
| 1-tert-butyl-3-[4-phenoxy-2,6-di(propan-2-yl)phenyl]thiourea |
| A839826 |
| C18781 |
| unii-22w5mdb01g |
| 22w5mdb01g , |
| FT-0603093 |
| AKOS015895255 |
| SCHEMBL27926 |
| diafenthiuron [mi] |
| thiourea, n-[2,6-bis(1-methylethyl)-4-phenoxyphenyl]-n'-(1,1-dimethylethyl)- |
| DTXSID1041845 |
| diafenthiuron, pestanal(r), analytical standard |
| 1-(tert-butyl)-3-(2,6-diisopropyl-4-phenoxyphenyl)thiourea |
| diafenthiuron 100 microg/ml in acetonitrile |
| Q15632894 |
| acetoaceticacid |
| thiourea,n-[2,6-bis(1-methylethyl)-4-phenoxyphenyl]-n'-(1,1-dimethylethyl)- |
| MS-26336 |
| CS-0129000 |
| HY-136394 |
| D5963 |
| mfcd01311814 |
Diafenthiuron is a traditional thiourea-based insecticide. It is rarely used to control pests on cruciferous vegetables due to its phytotoxicity.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Diafenthiuron is a traditional thiourea-based insecticide, but it is rarely used to control pests on cruciferous vegetables due to its phytotoxicity on these vegetables under high temperature and light conditions." | ( Sublethal effects of methylthio-diafenthiuron on the life table parameters and enzymatic properties of the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae). Su, C; Xia, X, 2020) | 1.56 |
| "Diafenthiuron is a thiourea compound that has a novel mode of action as it inhibits mitochondrial functioning in insect pests. " | ( Effect of Diafenthiuron exposure under short and long term experimental conditions on hematology, serum biochemical profile and elemental composition of a non-target organism, Labeo rohita. Amjad, M; Iqbal, F; Iram, S; Javeed, R; Rasheed, MA; Riaz-Ul-Haq, M, 2018) | 2.33 |
Diafenthiuron is a broad-spectrum insecticide and acaricide used for agricultural crop protection. Based on the hazard ratio (the ratio between the field-recommended dose and the LD(50) for the beneficial), diafENThiuron was found to be slightly to moderately toxic to bees.
| Excerpt | Reference | Relevance |
|---|---|---|
| " Based on the hazard ratio (the ratio between the field-recommended dose and the LD(50) for the beneficial), diafenthiuron was found to be slightly to moderately toxic to bees." | ( Toxicity of diafenthiuron to honey bees in laboratory, semi-field and field conditions. Chandrasekaran, S; Kuttalam, S; Preetha, G; Stanley, J, 2010) | 0.95 |
| "Diafenthiuron, a broad-spectrum insecticide and acaricide used for agricultural crop protection, is highly toxic to nontarget organisms." | ( Diafenthiuron causes developmental toxicity in zebrafish (Danio rerio). Bao, R; Gao, B; Li, W; Su, M; Wu, Y; Xiao, P, 2023) | 3.8 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bioassays were conducted in 2001 and 2002 to estimate toxicities and dose-response relationships of 24 Bemisica tabaci Gennadius populations to pyriproxifen, acemitaprid, and diafenthiuron." | ( Field efficacy and baseline toxicities of pyriproxifen, acetamiprid, and diafenthiuron against Bemisia tabaci Gennadius (Homoptera: Aleyrodidae) in Burkina Faso (West Africa). Otoidobiga, LC; Stewart, RK; Vincent, LC, 2003) | 0.74 |
| Role | Description |
|---|---|
| oxidative phosphorylation inhibitor | Any compound that inhibits oxidative phosphorylation. |
| proinsecticide | A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active insecticide for which it is a proinsecticide. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| thiourea acaricide | Any organosulfur acaracide that contains a thiourea moiety. |
| thiourea insecticide | Any organosulfur insecticide that contains a thiourea moiety. |
| aromatic ether | Any ether in which the oxygen is attached to at least one aryl substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 6 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (45.33) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||