Page last updated: 2024-09-28

Ichthyosis, Sex-Linked

Chronic form of ichthyosis that is inherited as a sex-linked recessive trait carried on the X-chromosome and transmitted to the male offspring. It is characterized by severe scaling, especially on the extremities, and is associated with steroid sulfatase deficiency.

Synonyms(5)

Synonym
Placental Steroid Sulfatase Deficiency
Steroid Sulfatase Deficiency
Steroid Sulfatase Deficiency Disease
Ichthyosis, Sex-Linked
Ichthyosis, X-Linked

Research Excerpts

Research

Studies (51)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's24 (47.06)12.5806
2000's15 (29.41)18.1394
2010's11 (21.57)28.8240
2020's1 (1.96)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dimethyl sulfoxide0low10
glycolic acid0low10
tazarotene0low30
estriol0low60
estrone0low30
androsterone0low10
dehydroepiandrosterone0low50
pilocarpine0low10
dimethyl sulfone0low10
pyrrolidonecarboxylic acid0low10
pregnenolone0low20
dehydroepiandrosterone sulfate0low70
pseudouridine0low10
vidarabine0medium11
lovastatin0low10
adenosine0low10
cholesteryl sulfate0low120
leupeptin0low10
4-methylumbelliferyl sulfate0low10
hexyl nicotinate0low10
pregnenolone sulfate0low20
16-hydroxydehydroepiandrosterone sulfate0low10
leupeptins0low10
melphalan0medium11
bromochloroacetic acid0low10
fludarabine0medium11
estrone sulfate0low30
sodium dodecyl sulfate0low10
sphingosine0low10
calcitriol0medium31
hymecromone0low10
isotretinoin0medium11
acitretin0low10
sulfur0low10
flag peptide0low10
11 beta-hydroxyandrosterone0low10
chymostatin0low10
calcipotriene0medium31
warfarin0low10
1 alpha,24-dihydroxyvitamin d30medium11

Protein Targets (495)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Broad substrate specificity ATP-binding cassette transporter ABCG20103
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Luciferase4004
USP1 protein, partial8008
TDP1 protein140014
Microtubule-associated protein tau5005
AR protein150015
aldehyde dehydrogenase 1 family, member A16006
glucocorticoid receptor [Homo sapiens]110011
estrogen nuclear receptor alpha140014
peroxisome proliferator activated receptor gamma110011
euchromatic histone-lysine N-methyltransferase 29009
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a8008
vitamin D3 receptor isoform VDRA5005
thyroid hormone receptor beta isoform 2110011
flap endonuclease 14004
serine/threonine-protein kinase PLK12002
eyes absent homolog 2 isoform a1001
DNA polymerase eta isoform 13003
geminin120012
peripheral myelin protein 226006
survival motor neuron protein isoform d4004
histone acetyltransferase KAT2A isoform 15005
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40809
Bile salt export pump0101
Bile salt export pump0909
Rap guanine nucleotide exchange factor 33003
Cellular tumor antigen p53110011
Rap guanine nucleotide exchange factor 43003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Membrane lipoprotein tmpC0011
Chain A, Structure of PAE2307 in complex with adenosine0011
Chain B, Structure of PAE2307 in complex with adenosine0011
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, ADENOSINE RECEPTOR A2A0101
Chain A, tRNA (guanine-N(1)-)-methyltransferase0011
Chain A, Uncharacterized protein MJ08830011
signal transducer and activator of transcription 6, interleukin-4 induced1001
regulator of G-protein signaling 43003
retinoid X nuclear receptor alpha120012
NPYLR7B0011
arylsulfatase A3003
IDH14004
Histone H2A.x4004
glycogen synthase kinase-3 beta isoform 10033
mitogen-activated protein kinase 14004
nuclear receptor ROR-gamma isoform 13003
high affinity choline transporter 1 isoform a0101
Sodium/nucleoside cotransporter 10202
Calcium dependent protein kinase0101
Mitogen-activated protein kinase kinase kinase 70011
Sodium/nucleoside cotransporter 20202
Voltage-dependent calcium channel gamma-2 subunit7007
Purine nucleoside phosphorylase0101
Epidermal growth factor receptor0101
Phosphoglycerate kinase 1 0101
Adenosine deaminase0001
Avidin0011
Adenosine deaminase0001
Glyceraldehyde-3-phosphate dehydrogenase0202
Receptor tyrosine-protein kinase erbB-20101
Insulin receptor0001
Phosphoglycerate kinase 20101
Heat shock protein HSP 90-alpha0112
Platelet-derived growth factor receptor beta0001
Adenosine receptor A30427
Heat shock 70 kDa protein 1A 0101
Heat shock cognate 71 kDa protein0011
Fibroblast growth factor receptor 10001
Inosine-5'-monophosphate dehydrogenase 20101
Endoplasmin0112
Glutamate receptor 27007
Inosine-5'-monophosphate dehydrogenase 1 0101
Fibroblast growth factor receptor 20001
Fibroblast growth factor receptor 40001
Fibroblast growth factor receptor 30001
Streptavidin0011
Adenosylhomocysteinase0001
Adenosine receptor A10113
Adenosine receptor A30202
Adenosine receptor A2a0124
Adenosine receptor A2b0012
Adenosine receptor A2b0112
Adenylate kinase 2, mitochondrial0101
Adenosine receptor A10427
Adenosine receptor A2a0113
Adenylate kinase isoenzyme 1 0101
Phosphatidylinositol 4-kinase alpha0203
Adenosine receptor A10011
Adenosine kinase0001
Adenosine deaminase 0003
Equilibrative nucleoside transporter 20202
Phosphatidylinositol 4-kinase type 2-beta0203
Histone-lysine N-methyltransferase, H3 lysine-79 specific0101
Equilibrative nucleoside transporter 10202
Phosphatidylinositol 4-kinase type 2-alpha0203
Solute carrier family 28 member 30202
Adenosine kinase0102
Phosphatidylinositol 4-kinase beta0203
5-methylthioadenosine/S-adenosylhomocysteine deaminase0001
Adenosine transporter 10001
Chain A, retinol dehydratase0101
acetylcholinesterase3003
RAR-related orphan receptor gamma120012
GLI family zinc finger 3120012
estrogen receptor 2 (ER beta)9009
progesterone receptor100010
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha120012
pregnane X nuclear receptor100010
v-jun sarcoma virus 17 oncogene homolog (avian)3003
Gamma-aminobutyric acid receptor subunit pi6107
Sex hormone-binding globulin0055
Corticosteroid-binding globulin0505
Glucose-6-phosphate 1-dehydrogenase0404
Androgen receptor0606
Gamma-aminobutyric acid receptor subunit beta-16107
Gamma-aminobutyric acid receptor subunit delta6107
Gamma-aminobutyric acid receptor subunit gamma-26107
Gamma-aminobutyric acid receptor subunit alpha-56107
Gamma-aminobutyric acid receptor subunit alpha-36107
Gamma-aminobutyric acid receptor subunit gamma-16107
Gamma-aminobutyric acid receptor subunit alpha-26107
Gamma-aminobutyric acid receptor subunit alpha-46107
Gamma-aminobutyric acid receptor subunit gamma-36107
Gamma-aminobutyric acid receptor subunit alpha-66107
Solute carrier organic anion transporter family member 1A10406
Gamma-aminobutyric acid receptor subunit alpha-16107
Gamma-aminobutyric acid receptor subunit beta-36107
Gamma-aminobutyric acid receptor subunit beta-26107
TAR DNA-binding protein 434004
G-protein coupled bile acid receptor 10033
GABA theta subunit6107
Gamma-aminobutyric acid receptor subunit epsilon6107
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0022
thioredoxin reductase6006
phosphopantetheinyl transferase4004
NFKB1 protein, partial2002
GLS protein3003
thyroid stimulating hormone receptor3003
alpha-galactosidase4004
cytochrome P450 2C19 precursor2002
chromobox protein homolog 16006
DNA polymerase iota isoform a (long)4004
muscarinic acetylcholine receptor M11001
lethal factor (plasmid)2002
Cytochrome P450 3A40204
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0001
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30101
ATP-dependent phosphofructokinase2002
nuclear receptor subfamily 1, group I, member 37007
thyroid stimulating hormone receptor5005
nuclear factor erythroid 2-related factor 2 isoform 1110011
Nuclear receptor ROR-gamma3003
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Beta-lactamase5005
Chain A, Ferritin light chain5005
Vitamin D3 receptor0011
PPM1D protein2002
thioredoxin glutathione reductase3003
Interferon beta6006
Vitamin D-binding protein0011
Cytochrome P450 1A20001
Androgen receptor0101
Cytochrome P450 2D60101
Vitamin D3 receptor0124
Cytochrome P450 2C9 0203
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0011
Cytochrome P450 2C190101
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0011
Vitamin D3 receptor0112
Transporter0101
Canalicular multispecific organic anion transporter 10505
Vitamin D3 receptor A0022
Cholesterol 24-hydroxylase0112
hypoxia-inducible factor 1 alpha subunit6006
SMAD family member 25005
SMAD family member 35005
cytochrome P450 family 3 subfamily A polypeptide 47007
farnesoid X nuclear receptor7007
cytochrome P450 2D64004
peroxisome proliferator-activated receptor delta8008
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
aryl hydrocarbon receptor2002
heat shock protein beta-14004
Beta-glucuronidase0101
Beta-glucuronidase0101
Alpha-synuclein1203
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
Solute carrier organic anion transporter family member 1A40002
Solute carrier organic anion transporter family member 1A50002
Steryl-sulfatase0305
Multidrug resistance-associated protein 1 0103
Solute carrier organic anion transporter family member 1A20002
Solute carrier organic anion transporter family member 1A30001
ATP-binding cassette sub-family C member 110001
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110002
Solute carrier organic anion transporter family member 1A10002
Solute carrier organic anion transporter family member 1B20002
Solute carrier organic anion transporter family member 1B10204
Chain A, 2-oxoglutarate Oxygenase4004
Cereblon isoform 40404
67.9K protein4004
cytochrome P450 3A4 isoform 16006
Choline O-acetyltransferase 0202
Protein cereblon0404
Insulin-like growth factor-binding protein 50011
Estrogen receptor0416
Glucocorticoid receptor0202
Glycine receptor subunit alpha-10202
Polyunsaturated fatty acid lipoxygenase ALOX150202
UDP-glucuronosyltransferase 2B70001
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Sodium-dependent serotonin transporter0404
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20112
UDP-glucuronosyltransferase 1A100001
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
endonuclease IV2002
ATAD5 protein, partial4004
GALC protein2002
nonstructural protein 11001
G4004
activating transcription factor 64004
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
Bloom syndrome protein isoform 13003
hexokinase-4 isoform 11001
peripheral myelin protein 22 isoform 12002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
glucokinase regulatory protein1001
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
lamin isoform A-delta109009
HLA class I histocompatibility antigen, B alpha chain 4004
Aromatase0101
17-beta-hydroxysteroid dehydrogenase type 10203
Mu-type opioid receptor0011
5-hydroxytryptamine receptor 2B0404
Mu-type opioid receptor0011
Inositol monophosphatase 11001
Cytochrome P450 1B10101
Inositol hexakisphosphate kinase 14004
Estrogen receptor beta0113
Ghrelin O-acyltransferase0101
cytochrome P450 2C9, partial4004
Estrogen receptor beta0001
Solute carrier organic anion transporter family member 2B1 0001
Tyrosine-protein phosphatase non-receptor type 10001
Estrogen receptor0001
Sodium/bile acid cotransporter0001
Solute carrier family 22 member 200101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Solute carrier organic anion transporter family member0001
Solute carrier organic anion transporter family member 1C10101
Solute carrier family 22 member 80102
Fumarate hydratase2002
Smad34004
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
corticotropin-releasing hormone receptor 20112
EWS/FLI fusion protein7007
polyprotein2002
corticotropin releasing factor-binding protein0112
nuclear factor erythroid 2-related factor 2 isoform 22002
5'-nucleotidase0101
DNA polymerase kappa isoform 11001
Cytochrome P450 2E10011
Chain A, HISTIDINE-BINDING PROTEIN0011
Carbonic anhydrase 120102
Carbonic anhydrase 10103
Carbonic anhydrase 20103
Plasma kallikrein0102
Carbonic anhydrase 30001
Histidine-binding periplasmic protein0011
Carbonic anhydrase 40001
Carbonic anhydrase 60001
5-hydroxytryptamine receptor 1D0001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
Glutaminyl-peptide cyclotransferase0101
Carbonic anhydrase 90102
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3B0001
Carbonic anhydrase 40001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
glucocerebrosidase3003
lysosomal alpha-glucosidase preproprotein1001
cytochrome P450 2C9 precursor2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
importin subunit beta-1 isoform 12002
snurportin-12002
caspase-1 isoform alpha precursor1001
Acetylcholinesterase0101
Aldo-keto reductase family 1 member B10303
Aldo-keto reductase family 1 member B10101
Nuclear factor NF-kappa-B p105 subunit0101
UDP-glucuronosyltransferase 1A1 0101
Genome polyprotein0101
Amine oxidase [flavin-containing] B0101
Testosterone 17-beta-dehydrogenase 30101
Histamine H2 receptor2002
Caspase-71001
Small conductance calcium-activated potassium channel protein 30101
Cholinesterase0101
Sorbitol dehydrogenase0101
Induced myeloid leukemia cell differentiation protein Mcl-10202
Oleandomycin glycosyltransferase0001
Chain A, Cruzipain4004
Parkin2002
Caspase-72002
thyroid hormone receptor beta isoform a4004
potassium voltage-gated channel subfamily H member 2 isoform d5005
caspase-32002
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Ornithine decarboxylase0001
Retinoic acid receptor alpha0101
Alpha-1B adrenergic receptor0202
Alpha-2B adrenergic receptor0202
Retinoic acid receptor gamma0101
Retinoic acid receptor beta0101
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0101
Retinoic acid receptor RXR-beta0101
Retinoic acid receptor RXR-gamma0101
Cellular retinoic acid-binding protein 10101
Alpha-1A adrenergic receptor0202
Cellular retinoic acid-binding protein 10011
Mitogen-activated protein kinase 140101
Cathepsin B 0101
Prothrombin 0101
Plasminogen0101
Cationic trypsin0101
Trypsin0101
Papain0101
Serine protease hepsin0101
Plasminogen 0101
Trypsin-10101
Trypsin-20101
Cathepsin B0101
Procathepsin L0101
Cathepsin B0202
Pro-cathepsin H0101
Trypsin-30101
Calpain-1 catalytic subunit0101
Cathepsin K0101
Hepatocyte growth factor activator0101
Transmembrane protease serine 60101
Cysteine protease0101
Cysteine proteinase falcipain 2a 0101
Cysteine protease falcipain-30101
Suppressor of tumorigenicity 14 protein0101
Chain A, Antigen Cd11a (p180)0101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
15-lipoxygenase, partial2002
pregnane X receptor1001
caspase 7, apoptosis-related cysteine protease2002
PINK11001
isocitrate dehydrogenase 1, partial1001
caspase-32002
thyrotropin-releasing hormone receptor1001
nuclear receptor subfamily 1, group I, member 22002
bcl-2-related protein A10202
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Integrin beta-20101
Intercellular adhesion molecule 10101
ATP-dependent translocase ABCB10101
Neutrophil elastase0101
Insulin receptor 0101
Integrin alpha-L0112
Substance-K receptor0202
Sodium-dependent noradrenaline transporter 0202
Prostaglandin G/H synthase 20101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Spike glycoprotein4004
Sodium-dependent dopamine transporter 0202
Histone deacetylase 10101
Lanosterol 14-alpha demethylase0202
Histone deacetylase 20101
Acyl-CoA:cholesterol acyltransferase 0101
Histone deacetylase 60101
glp-1 receptor, partial1001
Large neutral amino acids transporter small subunit 1 0101
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Vasopressin V2 receptor0112
Oxytocin receptor0224
Vasopressin V1a receptor0101
Vasopressin V1a receptor0213
Vasopressin V1b receptor0112
Vasopressin V1b receptor0101
Oxytocin receptor0101
Oxytocin receptor0011
Vasopressin V2 receptor 0101
Potassium voltage-gated channel subfamily H member 20101
Muscarinic acetylcholine receptor M20112
Muscarinic acetylcholine receptor M10203
Muscarinic acetylcholine receptor M30203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50101
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10123
Cytochrome P450 2A60112
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
Guanine nucleotide-binding protein G1001
Glutamate receptor ionotropic, NMDA 2D0112
Glutamate receptor ionotropic, NMDA 2A0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0112
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
interleukin 81001
Bifunctional epoxide hydrolase 20101
Peroxisome proliferator-activated receptor alpha1001
acid sphingomyelinase1001
apical membrane antigen 1, AMA11001
C-X-C chemokine receptor type 5 isoform 10101
DNA polymerase beta1001
ubiquitin-conjugating enzyme E2 N0101
C-C chemokine receptor type 60101
apelin receptor0101
streptokinase A precursor0011
Endoglycoceramidase II 0001
Protein kinase C alpha type0101
Estrogen receptor0011
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
cAMP-dependent protein kinase catalytic subunit alpha 0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Estrogen receptor beta0011
Protein kinase C eta type0101
Sphingosine kinase 20101
Sphingosine kinase 10101
Protein kinase C theta type0101
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Retinoic acid receptor alpha0011
Retinoic acid receptor beta0011
Retinoic acid receptor gamma 0011
Thymidine kinase, cytosolic0001
Dipeptidyl peptidase 40101
Histamine H1 receptor0011
Adenosylhomocysteinase0101
RNA-directed RNA polymerase 0112
Albumin0011
Albumin0011
Proprotein convertase subtilisin/kexin type 70101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 10101
Protease 0101
Vitamin K epoxide reductase complex subunit 1-like protein 10101
Vitamin K epoxide reductase complex subunit 1 0202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]