Page last updated: 2024-09-27

CCMMT

PEComas of the falciform ligament / ligamentum teres.

Synonyms(12)

Synonym
Neoplasms, Perivascular Epithelioid Cell
Perivascular Epithelioid Cell Neoplasm
CCMMT
Perivascular Epithelioid Cell Tumor
PEComa
Perivascular Epithelioid Cell Tumors
Perivascular Epithelioid Cell Neoplasms
PEComas
Clear-Cell Myomelanocytic Tumor
Clear-Cell Myomelanocytic Tumors
Clear-Cell Sugar Tumor
Clear-Cell Sugar Tumors

Research Excerpts

Overview

ExcerptReference
"Pecomas are rare, recently described mesenchymal tumors composed of perivascular epithelioid cells."( Chaplin, A; Conrad, DM; Covert, A; Jollimore, J; Pasternak, S; Tatlidil, C; Walsh, N, 2010)
"PEComa is a rare, recently described, family of tumors with diverse clinicopathologic expression and which express melanocytic and muscle markers."( Barrett, AW; Cascarini, L; Ghazali, N; Lavery, KM; Norris, P, 2010)
"Pediatric PEComas are rare, with less than 40 cases reported, mostly in children older than 5 years."( Alaggio, R; Bisogno, G; Cecchetto, G; Cheng, L; d'Amore, ES; Dall'Igna, P; Martignoni, G; Sperlì, D, 2012)
"Some types of PEComa are seen at high frequency in tuberous sclerosis complex (TSC)."( Antonescu, CR; Dickson, MA; Kwiatkowski, DJ; Malinowska, IA; Schwartz, GK, 2013)
"Perivascular epithelioid cell tumors are a family of related mesenchymal neoplasms that include angiomyolipoma, lymphangiomyomatosis, clear cell sugar tumor of the lung and a group of rare morphologically and immunophenotypically similar lesions that show immunoreactivity for both melanocytic (HMB-45 and/or melan-A) and smooth muscle (actin and/or desmin) markers."( Maya, M; Shringarpure, SS; Thachil, JV, 2012)
"Perivascular epithelioid cell tumors are mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells."( Carbone, A; Di Cristofano, C; Evangelista, S; Palleschi, G; Pastore, AL; Petrozza, V; Porta, N; Rossi, L; Silvestri, L; Tomao, S, 2014)
"Because pcPEComas are diagnostically challenging, we propose that micro-ophthalmia-associated transcription factor, NKIC3, smooth muscle actin, desmin, bcl-1, cathepsin K, and 4E-binding protein 1 can be used when evaluating a possible pcPEComa."( Charli-Joseph, Y; LeBoit, PE; Mirza, S; Saggini, A; Vemula, S; Weier, J, 2014)
"Perivascular epithelioid cell tumor is a rare tumor."( Gao, F; Huang, C; Sun, R; Wang, H; Zhang, S; Zhang, Y, 2016)
"Orbital PEComa is extremely rare with only two cases reported till date."( Alam, MS; Biswas, J; Krishnakumar, S; Mukherjee, B, 2017)
"Although omental PEComa is very rare, it should be considered as a differential disease of an omental primary tumor."( Akahane, T; Hashiguchi, Y; Hayama, T; Ishida, T; Kondo, F; Matsuda, K; Nozawa, K; Ohno, K; Okada, Y; Okamoto, K; Shimada, R; Tsuchiya, T; Tsukamoto, M; Yagi, T, 2018)
"PEComas are tumors with unpredictable behavior."( Damirov, F; Hohenberger, P; Menge, F, 2022)
"PEComas are most commonly found in females and often show either TSC1 or TSC2 alterations, which result in the activation of the mTOR pathway, or TFE3 fusions."( Basu Mallick, A; Bowne, WB; Chao, T; Jiang, W; McCue, PA; Meredith, L; Nevler, A; Singla, RK, 2023)

Context

ExcerptReference
"Extra-hepatorenal PEComa have distinctive morphologic features and are associated with TFE3 overexpression."( Li, L; Liu, B; Lu, ZF; Ma, HH; Rao, Q; Shen, Q; Shi, QL; Shi, SS; Tu, P; Wang, X; Xia, QY; Yu, B; Zhang, RS; Zhou, XJ, 2013)
"pcPEComas have a different molecular signature than extracutaneous tumors and are unrelated to tuberous sclerosis."( Charli-Joseph, Y; LeBoit, PE; Mirza, S; Saggini, A; Vemula, S; Weier, J, 2014)
"Although PEComas have the potential to behave in a malignant fashion, malignant PEComas arising from the retroperitoneum are extremely rare."( Cha, RR; Jung, WT; Kim, HJ; Kim, NY; Kim, TH; Lee, JH; Lee, OJ; Oh, HW, 2014)

Treatment

ExcerptReference
"A case of bone metastatic bladder perivascular epithelioid cell tumor in a 65-year-old Caucasian man treated with surgery and chemotherapy is described and compared with other reports in the literature."( Carbone, A; Di Cristofano, C; Evangelista, S; Palleschi, G; Pastore, AL; Petrozza, V; Porta, N; Rossi, L; Silvestri, L; Tomao, S, 2014)
"This first case of pancreatic PEComa treated by mTOR inhibitor without surgery suggests a good efficiency of this therapy."( Gondran, H; Le Rhun, M; Moreau, A; Musquer, N; Regenet, N; Thebaud, E; Touchefeu, Y, 2019)
"Perivascular epitheliod cell tumors (PEComas) are rare mesenchymal neoplasms for which the role of systemic treatments is not established as there are no published prospective clinical trials or sufficiently large retrospective case series."( Antoniou, G; Bertulli, R; Blay, JY; Brahmi, M; Casali, PG; Collini, P; Dei Tos, AP; Dufresne, A; FucĂ , G; Fumagalli, E; Gronchi, A; Grosso, F; Hindi, N; Jones, RL; Le Cesne, A; Mir, O; Provenzano, S; Sanfilippo, R; Sbaraglia, M; Stacchiotti, S, 2019)

Research

Studies (54)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's1 (1.85)18.1394
2010's38 (70.37)28.8240
2020's15 (27.78)9.53
DrugIndicatedRelationship StrengthStudiesTrials
niacinamide0low10
ifosfamide0low10
indazoles0low10
pyrazines0low10
perfluorobutane0low10
deoxycytidine0low20
etoposide0low10
propiconazole0low20
topotecan0low10
gemcitabine0low20
fluorodeoxyglucose f180low90
imatinib mesylate0low10
sorafenib0low20
bortezomib0low10
glycogen0low10
sirolimus0low190
everolimus0low50
mart-1 antigen0low170
pazopanib0low10
trelstar0low10
cyclin d10low20
eye0low10

Protein Targets (819)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain H, Proteasome component PUP10101
Chain I, Proteasome component PUP30101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Chain K, Proteasome component PRE20101
Chain L, Proteasome component C50101
Proteasome subunit beta type-110101
RAR-related orphan receptor gamma4004
Fumarate hydratase5005
PPM1D protein4004
TDP1 protein8008
AR protein7007
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 35005
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 43003
EWS/FLI fusion protein6006
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 15005
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha7007
farnesoid X nuclear receptor5005
pregnane X nuclear receptor7007
estrogen nuclear receptor alpha8008
polyprotein5005
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-32002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
nuclear receptor subfamily 1, group I, member 21001
Histone H2A.x2002
Caspase-72002
caspase-32002
thyroid hormone receptor beta isoform 27007
heat shock protein beta-12002
nuclear factor erythroid 2-related factor 2 isoform 15005
26S proteasome non-ATPase regulatory subunit 110101
26S proteasome non-ATPase regulatory subunit 120101
26S proteasome non-ATPase regulatory subunit 140101
Proteasome subunit alpha type-70101
Histone deacetylase 30101
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
26S proteasome non-ATPase regulatory subunit 30101
Carbonic anhydrase 120101
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump0707
Prothrombin0102
Chymotrypsinogen A0101
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Interferon beta4004
Cellular tumor antigen p535005
Carbonic anhydrase 30101
Cathepsin B0101
Neutrophil elastase0101
Cathepsin G0202
Lysosomal protective protein0101
Chymotrypsinogen B0101
26S proteasome regulatory subunit 6A0101
Glutamate receptor 25005
Nuclear factor NF-kappa-B p105 subunit0101
Proteasome subunit beta type-10102
Carbonic anhydrase 40101
Carbonic anhydrase 60101
Chymase0101
Proteasome subunit alpha type-10101
Proteasome subunit alpha type-20101
Proteasome subunit alpha type-30101
Proteasome subunit alpha type-40101
Proteasome subunit beta type-80101
Proteasome subunit beta type-80101
Proteasome subunit beta type-90101
Proteasome subunit alpha type-50101
Proteasome subunit beta type-40101
Proteasome subunit beta type-60101
Proteasome subunit beta type-50203
Carbonic anhydrase 5A, mitochondrial0101
26S proteasome regulatory subunit 70101
Lon protease homolog, mitochondrial0101
Proteasome subunit beta type-100101
Carbonic anhydrase 70202
26S proteasome regulatory subunit 6B0145
26S proteasome non-ATPase regulatory subunit 80101
Proteasome subunit beta type-30101
Proteasome subunit beta type-20102
26S proteasome non-ATPase regulatory subunit 70101
26S proteasome non-ATPase regulatory subunit 40101
26S proteasome complex subunit SEM10101
Proteasome subunit alpha type-60101
26S proteasome regulatory subunit 40101
26S proteasome regulatory subunit 80101
26S proteasome regulatory subunit 10B0101
Beta-carbonic anhydrase 10101
Nuclear factor NF-kappa-B p100 subunit 0101
Transcription factor p650101
26S proteasome non-ATPase regulatory subunit 20101
Histone deacetylase 10101
26S proteasome non-ATPase regulatory subunit 60101
Proteasomal ubiquitin receptor ADRM10101
Carbonic anhydrase 90303
ATP-dependent Clp protease proteolytic subunit0112
Carbonic anhydrase 130101
NACHT, LRR and PYD domains-containing protein 3 0101
Proteasome subunit alpha-type 80101
Histone deacetylase 20101
Canalicular multispecific organic anion transporter 10607
ATPase family AAA domain-containing protein 57007
Proteasome subunit beta type-70101
26S proteasome non-ATPase regulatory subunit 10101
Ataxin-27007
Carbonic anhydrase 150101
Histone deacetylase 80101
Histone deacetylase 60101
Carbonic anhydrase 140101
26S proteasome non-ATPase regulatory subunit 130101
Carbonic anhydrase 5B, mitochondrial0101
Thymidine kinase 2 0101
Deoxycytidine kinase0046
Probable deoxycytidylate deaminase0001
Cytidine deaminase0002
AAA family ATPase 0002
Reverse transcriptase/RNaseH 0011
Genome polyprotein 0101
Tyrosine-protein kinase Fyn0145
UDP-glucuronosyltransferase 2B70001
Spike glycoprotein3014
glp-1 receptor, partial3003
hypoxia-inducible factor 1 alpha subunit1001
SMAD family member 23003
SMAD family member 33003
GLI family zinc finger 36006
67.9K protein3003
LMP1 [Human herpesvirus 4]0001
thyroid stimulating hormone receptor2002
activating transcription factor 62002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
chromobox protein homolog 13003
nuclear factor erythroid 2-related factor 2 isoform 21001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
DNA polymerase iota isoform a (long)3003
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
geminin6006
nuclear receptor coactivator 3 isoform a0101
Regulatory protein E20011
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10304
Cytochrome P450 3A40607
DNA topoisomerase 10226
DNA topoisomerase 2-alpha02512
Cytochrome P450 2C9 0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
DNA topoisomerase 20001
ATP-dependent translocase ABCB10101
UDP-glucuronosyltransferase 1A1 0001
Serum paraoxonase/arylesterase 10202
Glutamate receptor ionotropic, NMDA 1 0001
Caspase-30101
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
DNA topoisomerase 2-alpha 0001
DNA topoisomerase 2-beta02513
Glutamate receptor ionotropic, NMDA 2D0001
Tubulin beta-2B chain0101
Integrase 0101
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Glutamate receptor ionotropic, NMDA 3B0001
Solute carrier organic anion transporter family member 1B30202
Glutamate receptor ionotropic, NMDA 3A0001
USP1 protein, partial3003
vitamin D3 receptor isoform VDRA2002
nuclear receptor ROR-gamma isoform 14004
peripheral myelin protein 222002
Bone morphogenetic protein receptor type-1B0044
Cell division cycle 7-related protein kinase0033
Serine/threonine-protein kinase PLK40145
ATP-dependent RNA helicase DDX3X0044
Pyridoxal kinase0044
Citron Rho-interacting kinase0044
Serine/threonine-protein kinase Chk10044
Aurora kinase A0145
Cyclin-G-associated kinase0044
Ephrin type-B receptor 60044
Peroxisomal acyl-coenzyme A oxidase 30044
Receptor-interacting serine/threonine-protein kinase 20145
Mitotic checkpoint serine/threonine-protein kinase BUB10044
Dynamin-like 120 kDa protein, mitochondrial0044
Eukaryotic translation initiation factor 5B0022
Rho-associated protein kinase 20044
Serine/threonine-protein kinase ULK10044
Serine/threonine-protein kinase/endoribonuclease IRE10044
Ribosomal protein S6 kinase alpha-50044
U5 small nuclear ribonucleoprotein 200 kDa helicase0044
Ribosomal protein S6 kinase alpha-40044
Serine/threonine-protein kinase 160044
Serine/threonine-protein kinase 100044
Serine/threonine-protein kinase D30044
Structural maintenance of chromosomes protein 20044
Mitogen-activated protein kinase kinase kinase 60044
Mitogen-activated protein kinase kinase kinase kinase 40044
Serine/threonine-protein kinase LATS10044
Serine/threonine-protein kinase PAK 40044
Tyrosine-protein kinase ABL10459
Epidermal growth factor receptor0145
High affinity nerve growth factor receptor0044
Guanine nucleotide-binding protein G(i) subunit alpha-20022
ADP/ATP translocase 20044
Protein kinase C beta type0044
Insulin receptor0145
Tyrosine-protein kinase Lck0145
Cyclin-dependent kinase 10145
Glycogen phosphorylase, liver form0044
Tyrosine-protein kinase Fes/Fps0044
Adenine phosphoribosyltransferase0033
Tyrosine-protein kinase Yes0044
Tyrosine-protein kinase Lyn0044
Proto-oncogene tyrosine-protein kinase receptor Ret0246
Insulin-like growth factor 1 receptor0044
Signal recognition particle receptor subunit alpha0033
Cytochrome c1, heme protein, mitochondrial0044
Hepatocyte growth factor receptor0145
Tyrosine-protein kinase HCK0145
Platelet-derived growth factor receptor beta0246
Tyrosine-protein kinase Fgr0044
Serine/threonine-protein kinase A-Raf0145
Glycogen phosphorylase, brain form0044
Breakpoint cluster region protein0156
Serine/threonine-protein kinase pim-10044
Fibroblast growth factor receptor 10246
Cyclin-dependent kinase 40145
ADP/ATP translocase 30044
Inosine-5'-monophosphate dehydrogenase 20044
Proto-oncogene tyrosine-protein kinase Src0145
cAMP-dependent protein kinase type II-alpha regulatory subunit0044
Serine/threonine-protein kinase B-raf0358
Potassium voltage-gated channel subfamily E member 10101
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0044
Ribosyldihydronicotinamide dehydrogenase [quinone]0044
Tyrosine-protein kinase Fer0044
Protein kinase C alpha type0044
cAMP-dependent protein kinase catalytic subunit alpha0044
General transcription and DNA repair factor IIH helicase subunit XPD0044
Casein kinase II subunit alpha'0044
Ras-related protein Rab-6A0033
Ephrin type-A receptor 10044
Multifunctional protein ADE20044
cAMP-dependent protein kinase catalytic subunit gamma0033
cAMP-dependent protein kinase catalytic subunit beta0044
Ferrochelatase, mitochondrial0044
Ribosomal protein S6 kinase beta-10044
Tyrosine-protein kinase JAK10044
Cyclin-dependent kinase 20246
Beta-adrenergic receptor kinase 10044
Probable ATP-dependent RNA helicase DDX60044
Mitogen-activated protein kinase 3 0145
MAP/microtubule affinity-regulating kinase 30044
Mitogen-activated protein kinase 10145
Ephrin type-A receptor 20044
Ephrin type-B receptor 20044
Non-receptor tyrosine-protein kinase TYK20044
UMP-CMP kinase 0022
Phosphatidylethanolamine-binding protein 10033
Wee1-like protein kinase0044
Heme oxygenase 20044
S-adenosylmethionine synthase isoform type-20044
DnaJ homolog subfamily A member 10044
RAC-alpha serine/threonine-protein kinase0145
RAC-beta serine/threonine-protein kinase0044
Dual specificity protein kinase TTK0044
DNA replication licensing factor MCM40044
Myosin-100033
Dual specificity mitogen-activated protein kinase kinase 20044
Receptor-type tyrosine-protein kinase FLT30246
Bone morphogenetic protein receptor type-1A0044
Activin receptor type-1B0044
TGF-beta receptor type-10044
TGF-beta receptor type-20044
Electron transfer flavoprotein subunit beta0033
Tyrosine-protein kinase CSK0044
Glycine--tRNA ligase0044
Protein kinase C iota type0044
Exosome RNA helicase MTR40044
Serine/threonine-protein kinase mTOR0347
Tyrosine-protein kinase Tec0044
Tyrosine-protein kinase ABL20044
Tyrosine-protein kinase FRK0044
G protein-coupled receptor kinase 60044
Tyrosine-protein kinase SYK0044
Mitogen-activated protein kinase 80044
Mitogen-activated protein kinase 90044
Dual specificity mitogen-activated protein kinase kinase 30044
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0044
Casein kinase I isoform alpha0145
Casein kinase I isoform delta0044
MAP kinase-activated protein kinase 20044
Elongation factor Tu, mitochondrial0044
Choline-phosphate cytidylyltransferase A0022
Cysteine--tRNA ligase, cytoplasmic0044
Casein kinase I isoform epsilon0044
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0044
Dual specificity protein kinase CLK10044
Dual specificity protein kinase CLK20044
Dual specificity protein kinase CLK30044
Glycogen synthase kinase-3 alpha0044
Glycogen synthase kinase-3 beta0145
Cyclin-dependent kinase 70044
Cyclin-dependent kinase 90044
Ras-related protein Rab-27A0044
Interleukin-1 receptor-associated kinase 10044
Potassium voltage-gated channel subfamily KQT member 10101
Ribosomal protein S6 kinase alpha-30044
Serine/threonine-protein kinase Nek20044
Serine/threonine-protein kinase Nek30044
Dual specificity mitogen-activated protein kinase kinase 60044
Serine/threonine-protein kinase PLK10145
LIM domain kinase 10044
LIM domain kinase 20044
Mitogen-activated protein kinase 100044
Tyrosine--tRNA ligase, cytoplasmic0044
5'-AMP-activated protein kinase subunit gamma-10044
Ephrin type-B receptor 30044
Ephrin type-A receptor 50044
Ephrin type-B receptor 40145
Ephrin type-A receptor 40044
Adenylate kinase 2, mitochondrial0044
Adenosine kinase0044
Ras-related protein Rab-100044
Actin-related protein 30044
Actin-related protein 20044
GTP-binding nuclear protein Ran0044
Casein kinase I isoform gamma-20044
Cyclin-dependent kinase 30033
Cyclin-dependent kinase 60145
Cyclin-dependent-like kinase 5 0044
Cyclin-dependent kinase 160044
Cyclin-dependent kinase 170044
ATP-dependent 6-phosphofructokinase, platelet type0044
Dual specificity mitogen-activated protein kinase kinase 10145
Protein kinase C theta type0044
Activin receptor type-10044
Macrophage-stimulating protein receptor0044
Focal adhesion kinase 10044
Protein kinase C delta type0044
Tyrosine-protein kinase BTK0044
Activated CDC42 kinase 10044
Epithelial discoidin domain-containing receptor 10044
Potassium voltage-gated channel subfamily H member 20101
Mitogen-activated protein kinase kinase kinase kinase 20044
Serine/threonine-protein kinase 40044
5'-AMP-activated protein kinase catalytic subunit alpha-10044
Dual specificity mitogen-activated protein kinase kinase 50044
Mitogen-activated protein kinase 70044
Serine/threonine-protein kinase PAK 20044
Serine/threonine-protein kinase 30044
Mitogen-activated protein kinase kinase kinase 10044
Integrin-linked protein kinase0044
Rho-associated protein kinase 10044
Non-receptor tyrosine-protein kinase TNK10044
Calcium/calmodulin-dependent protein kinase type II subunit gamma0044
Calcium/calmodulin-dependent protein kinase type II subunit delta0044
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0044
Activin receptor type-2B0044
Bone morphogenetic protein receptor type-20044
Protein-tyrosine kinase 60044
cGMP-dependent protein kinase 1 0044
Cyclin-dependent kinase 130044
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0044
Protein-tyrosine kinase 2-beta0044
Sodium channel protein type 5 subunit alpha0101
Maternal embryonic leucine zipper kinase0044
Structural maintenance of chromosomes protein 1A0044
Chromodomain-helicase-DNA-binding protein 40044
Peroxisomal acyl-coenzyme A oxidase 10044
Ephrin type-A receptor 70033
Delta(24)-sterol reductase0044
Ribosomal protein S6 kinase alpha-10044
Dual specificity testis-specific protein kinase 10044
Myosin light chain kinase, smooth muscle0044
Mitogen-activated protein kinase 110044
Serine/threonine-protein kinase STK110044
Serine/threonine-protein kinase N10044
Serine/threonine-protein kinase N20044
Mitogen-activated protein kinase 140145
Calcium/calmodulin-dependent protein kinase type IV0044
Mitogen-activated protein kinase kinase kinase 110044
Discoidin domain-containing receptor 20246
AP2-associated protein kinase 10044
Myosin light chain kinase 30044
Putative heat shock protein HSP 90-beta 20044
Serine/threonine-protein kinase MRCK alpha0044
Serine/threonine-protein kinase MRCK gamma0044
Acyl-CoA dehydrogenase family member 100044
Serine/threonine-protein kinase N30044
Serine/threonine-protein kinase ULK30044
Uncharacterized protein FLJ452520044
Acyl-CoA dehydrogenase family member 110044
Serine/threonine-protein kinase/endoribonuclease IRE20033
Serine/threonine-protein kinase MARK20044
ATP-dependent RNA helicase DHX300044
Serine/threonine-protein kinase TAO10044
STE20-related kinase adapter protein alpha0044
Myosin-140044
AarF domain-containing protein kinase 10044
ATP-dependent RNA helicase DDX420022
Mitogen-activated protein kinase kinase kinase kinase 30044
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B0011
Regulatory-associated protein of mTOR0202
Atypical kinase COQ8A, mitochondrial0044
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0044
Mitogen-activated protein kinase 150044
Serine/threonine-protein kinase Nek90044
Serine/threonine-protein kinase Nek70033
ATP-dependent RNA helicase DDX10044
Mitogen-activated protein kinase kinase kinase kinase 10044
Aurora kinase B0044
MAP/microtubule affinity-regulating kinase 40044
Serine/threonine-protein kinase Nek10044
PAS domain-containing serine/threonine-protein kinase0033
Calcium/calmodulin-dependent protein kinase kinase 20044
EKC/KEOPS complex subunit TP53RK0044
Dual specificity testis-specific protein kinase 20033
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0044
Mitogen-activated protein kinase kinase kinase 50044
Mitogen-activated protein kinase kinase kinase 30044
Eukaryotic translation initiation factor 2-alpha kinase 10044
Target of rapamycin complex subunit LST80202
Nucleolar GTP-binding protein 10044
Serine/threonine-protein kinase D20044
NUAK family SNF1-like kinase 20033
RNA cytidine acetyltransferase0044
Serine/threonine-protein kinase SIK20044
STE20-like serine/threonine-protein kinase 0044
Serine/threonine-protein kinase TAO30044
dCTP pyrophosphatase 10044
Dual specificity protein kinase CLK40044
Casein kinase I isoform gamma-10044
Phenylalanine--tRNA ligase beta subunit0044
BMP-2-inducible protein kinase0044
Obg-like ATPase 10044
Midasin0044
Interleukin-1 receptor-associated kinase 40044
Mitogen-activated protein kinase kinase kinase 200044
Cyclin-dependent kinase 120044
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 130033
Serine/threonine-protein kinase 260044
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0044
Serine/threonine-protein kinase NLK0044
5'-AMP-activated protein kinase subunit gamma-20044
Serine/threonine-protein kinase TBK10044
Septin-90044
Potassium voltage-gated channel subfamily D member 30101
Ribosomal protein S6 kinase alpha-60044
TRAF2 and NCK-interacting protein kinase0044
Serine/threonine-protein kinase TAO20044
Long-chain-fatty-acid--CoA ligase 50033
RAC-gamma serine/threonine-protein kinase0044
Serine/threonine-protein kinase SIK30044
Mitogen-activated protein kinase kinase kinase 20044
Thyroid hormone receptor-associated protein 30033
Mitogen-activated protein kinase kinase kinase kinase 50044
Receptor-interacting serine/threonine-protein kinase 30145
Serine/threonine-protein kinase MRCK beta0044
Interleukin-1 receptor-associated kinase 30044
Casein kinase I isoform gamma-30044
Mitogen-activated protein kinase kinase kinase 40044
Chain A, DEOXYNUCLEOSIDE KINASE0101
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Equilibrative nucleoside transporter 10101
Angiotensin-converting enzyme 2 0011
Chain A, Beta-lactamase2002
GALC protein1001
lamin isoform A-delta101001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Luciferase2002
acetylcholinesterase2002
thioredoxin reductase1001
IDH11001
aryl hydrocarbon receptor4004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
serine/threonine-protein kinase mTOR isoform 11001
DNA repair protein RAD52 homolog isoform a0001
Cytochrome P450 2C80001
Mast/stem cell growth factor receptor Kit0336
Platelet-derived growth factor receptor alpha0336
Cytochrome P450 3A50102
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, CELL DIVISION PROTEIN KINASE 20101
Chain A, Cell Division Protein Kinase 20101
DNA repair and recombination protein RadA0011
Heat shock protein HSP 90-alpha0011
G2/mitotic-specific cyclin-B10101
Indoleamine 2,3-dioxygenase 10011
Cyclin-A20101
Nitric oxide synthase, brain0101
Cyclin-A10101
HLA class I histocompatibility antigen, A alpha chain 0101
5-hydroxytryptamine receptor 2C0101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2B0101
Gastrin/cholecystokinin type B receptor0101
Chain A, NAD-dependent deacetylase0101
histone acetyltransferase KAT2A isoform 11001
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Tissue factor0101
NAD-dependent protein deacetylase HST20101
Fatty-acid amide hydrolase 10202
Protein mono-ADP-ribosyltransferase PARP150101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
Leukotriene C4 synthase0022
G1001
cytochrome P450 2D61001
tyrosine-protein kinase Yes3003
Membrane-associated progesterone receptor component 10022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform0123
Serine/threonine-protein kinase 250022
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta0022
Serine/threonine-protein kinase RIO30022
Dual specificity mitogen-activated protein kinase kinase 70022
Inhibitor of nuclear factor kappa-B kinase subunit beta0022
Peripheral plasma membrane protein CASK0022
Serine/threonine-protein kinase DCLK10022
Inhibitor of nuclear factor kappa-B kinase subunit alpha0022
Muscle, skeletal receptor tyrosine-protein kinase0022
Mitogen-activated protein kinase 130022
3-phosphoinositide-dependent protein kinase 10022
Mitogen-activated protein kinase kinase kinase 130022
Death-associated protein kinase 30022
Mitogen-activated protein kinase kinase kinase 70022
NUAK family SNF1-like kinase 10022
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma0022
Tyrosine-protein kinase JAK20033
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma0022
Serine/threonine-protein kinase PAK 30022
Cyclin-dependent kinase-like 50033
Serine/threonine-protein kinase 17B0022
Cyclin-dependent kinase 140022
Serine/threonine-protein kinase OSR10022
Serine/threonine-protein kinase Chk20022
HLA class I histocompatibility antigen, B alpha chain 1001
RAF proto-oncogene serine/threonine-protein kinase0224
Receptor tyrosine-protein kinase erbB-20123
Macrophage colony-stimulating factor 1 receptor0224
Proto-oncogene tyrosine-protein kinase ROS0022
Wee1-like protein kinase 20022
Uncharacterized serine/threonine-protein kinase SBK30022
Cytochrome P450 2D60101
Myosin light chain kinase, smooth muscle0022
Insulin receptor-related protein0022
Vascular endothelial growth factor receptor 1 0224
Interferon-induced, double-stranded RNA-activated protein kinase0022
Serine/threonine-protein kinase MAK0022
Cyclin-dependent kinase 11B0022
Fibroblast growth factor receptor 20123
Receptor tyrosine-protein kinase erbB-30022
Acetylcholinesterase0101
Fibroblast growth factor receptor 40022
Fibroblast growth factor receptor 30022
Protein kinase C eta type0022
Activin receptor type-2A0022
Ephrin type-A receptor 30022
Ephrin type-A receptor 80022
Leukocyte tyrosine kinase receptor0022
Tyrosine-protein kinase receptor UFO0022
Mitogen-activated protein kinase 40022
G protein-coupled receptor kinase 40022
Prostaglandin G/H synthase 20022
Tyrosine-protein kinase receptor Tie-10022
Vascular endothelial growth factor receptor 30224
Vascular endothelial growth factor receptor 20337
Serine/threonine-protein kinase receptor R30033
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform0123
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform0123
Megakaryocyte-associated tyrosine-protein kinase0022
Tyrosine-protein kinase TXK0022
Tyrosine-protein kinase ZAP-700022
Dual specificity mitogen-activated protein kinase kinase 40022
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0123
Cyclin-dependent kinase 80123
Tyrosine-protein kinase Blk0022
Cytoplasmic tyrosine-protein kinase BMX0022
cAMP-dependent protein kinase catalytic subunit PRKX0022
Serine/threonine-protein kinase Nek40022
Tyrosine-protein kinase JAK30022
Death-associated protein kinase 10022
Mitogen-activated protein kinase 120022
5'-AMP-activated protein kinase catalytic subunit alpha-20022
Ephrin type-B receptor 10022
Hormonally up-regulated neu tumor-associated kinase0022
Serine/threonine-protein kinase SIK10022
Receptor-interacting serine/threonine-protein kinase 40022
Cell division control protein 2 homolog0022
Calcium-dependent protein kinase 10022
Tubulin alpha-1A chain0022
Casein kinase II subunit alpha0022
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta0022
SRSF protein kinase 20022
Mitogen-activated protein kinase kinase kinase 90022
Serine/threonine-protein kinase PknB0022
Cyclin-dependent kinase-like 10022
Protein kinase C epsilon type0022
Angiopoietin-1 receptor0123
Mitogen-activated protein kinase kinase kinase 100022
Tyrosine-protein kinase receptor TYRO30022
Cyclin-dependent kinase 180033
Tyrosine-protein kinase ITK/TSK0022
Myotonin-protein kinase0022
Mitogen-activated protein kinase kinase kinase 120022
Tyrosine-protein kinase Mer0134
Serine/threonine-protein kinase PAK 10022
cGMP-dependent protein kinase 20022
Serine/threonine-protein kinase PRP4 homolog0022
Receptor-interacting serine/threonine-protein kinase 10224
Calcium/calmodulin-dependent protein kinase type II subunit beta0022
Calcium/calmodulin-dependent protein kinase type 10022
Serine/threonine-protein kinase D10022
Serine/threonine-protein kinase 380022
Receptor tyrosine-protein kinase erbB-40022
Ribosomal protein S6 kinase alpha-20022
Rhodopsin kinase GRK10022
NT-3 growth factor receptor0022
BDNF/NT-3 growth factors receptor0022
Mitogen-activated protein kinase 60022
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform0022
Receptor protein-tyrosine kinase 0101
Serine/threonine-protein kinase SBK10022
Mitogen-activated protein kinase kinase kinase 190022
Serine/threonine-protein kinase TNNI3K0123
Rab-like protein 30022
Leucine-rich repeat serine/threonine-protein kinase 20022
Serine/threonine-protein kinase Nek50022
Dual serine/threonine and tyrosine protein kinase0022
Mitogen-activated protein kinase kinase kinase 150022
Serine/threonine-protein kinase tousled-like 20022
Serine/threonine-protein kinase 32C0022
Serine/threonine-protein kinase pim-30022
Serine/threonine-protein kinase VRK20022
Myosin light chain kinase family member 40022
Homeodomain-interacting protein kinase 10123
Calcium/calmodulin-dependent protein kinase type 1D0022
Cyclin-dependent kinase-like 30022
MAP kinase-activated protein kinase 50033
Serine/threonine-protein kinase BRSK20022
Serine/threonine-protein kinase NIM10022
Serine/threonine-protein kinase ULK20022
Misshapen-like kinase 10033
Serine/threonine-protein kinase DCLK20022
Calcium/calmodulin-dependent protein kinase kinase 10022
Casein kinase I isoform alpha-like0022
Homeodomain-interacting protein kinase 40123
Myosin-IIIa0022
Ankyrin repeat and protein kinase domain-containing protein 10022
Serine/threonine-protein kinase Nek110022
Serine/threonine-protein kinase BRSK10022
Serine/threonine-protein kinase 350022
Rhodopsin kinase GRK70022
Serine/threonine-protein kinase 32A0022
Myosin-IIIb0022
Inositol hexakisphosphate kinase 11001
Dual specificity tyrosine-phosphorylation-regulated kinase 20022
Cyclin-dependent kinase-like 20022
Serine/threonine-protein kinase Sgk30022
Atypical kinase COQ8B, mitochondrial0022
Calcium/calmodulin-dependent protein kinase type 1G0033
Cyclin-dependent kinase 150022
SRSF protein kinase 10022
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha0022
Serine/threonine-protein kinase RIO10022
MAP kinase-interacting serine/threonine-protein kinase 10022
Serine/threonine-protein kinase RIO20022
Cyclin-dependent kinase 190123
Transient receptor potential cation channel subfamily M member 60022
Testis-specific serine/threonine-protein kinase 10022
Serine/threonine-protein kinase 330022
Serine/threonine-protein kinase DCLK30022
Myosin light chain kinase 2, skeletal/cardiac muscle0022
Homeodomain-interacting protein kinase 20123
Tyrosine-protein kinase Srms0022
Homeodomain-interacting protein kinase 30123
Serine/threonine-protein kinase PLK30123
MAP kinase-interacting serine/threonine-protein kinase 20123
Serine/threonine-protein kinase Nek60022
Serine/threonine-protein kinase PAK 60022
SNF-related serine/threonine-protein kinase0022
Serine/threonine-protein kinase LATS20022
Serine/threonine-protein kinase 360022
Isoleucine--tRNA ligase, mitochondrial0033
Serine/threonine-protein kinase 32B0022
Serine/threonine-protein kinase PLK20123
Serine/threonine-protein kinase MARK10022
Serine/threonine-protein kinase pim-20022
Serine/threonine-protein kinase PAK 50022
eIF-2-alpha kinase GCN20022
Phosphatidylinositol 4-kinase beta0022
Serine/threonine-protein kinase 17A0022
STE20/SPS1-related proline-alanine-rich protein kinase0022
Ephrin type-A receptor 60022
Death-associated protein kinase 20022
Serine/threonine-protein kinase tousled-like 10022
ALK tyrosine kinase receptor0022
SRSF protein kinase 30022
Serine/threonine-protein kinase ICK0033
Cyclin-dependent kinase 11A0022
Aurora kinase C0022
Calcium/calmodulin-dependent protein kinase type II subunit alpha0022
Serine/threonine-protein kinase 38-like0022
Microtubule-associated serine/threonine-protein kinase 10022
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0033
Serine/threonine-protein kinase 240033
cytochrome P450 2C9, partial1001
Chain A, Ferritin light chain1001
pregnane X receptor1001
phosphopantetheinyl transferase1001
nonstructural protein 11001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid hormone receptor beta isoform a1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Histamine H2 receptor1001
Guanine nucleotide-binding protein G1001
TAR DNA-binding protein 431001
heat shock protein 90, putative0001
Smad32002
Nuclear receptor subfamily 1 group I member 20011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Eukaryotic translation initiation factor 4E0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
Cytochrome P450 2C190101
Alpha-synuclein2002
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Protein kinase C zeta type0022
Peptidyl-prolyl cis-trans isomerase FKBP50101
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Serine/threonine-protein kinase mTOR 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20303
Solute carrier organic anion transporter family member 1B10101
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, Mitogen-activated protein kinase 140011
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 20101
melanocortin receptor 40112
Tyrosine-protein kinase ABL10101
Platelet-derived growth factor receptor beta0101
5-hydroxytryptamine receptor 1A0101
Aromatase0101
G1/S-specific cyclin-D10101
Cyclin-C0112
Serine/threonine-protein kinase B-raf 0101
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 2C0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0011
Bifunctional epoxide hydrolase 20101
5-hydroxytryptamine receptor 70101
Vascular endothelial growth factor receptor 30101
Vascular endothelial growth factor receptor 20101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 60101
DNA-dependent protein kinase catalytic subunit0101
Protein delta homolog 10011
Serine/threonine-protein kinase ATR0011
MAP kinase-activated protein kinase 30011
Vascular endothelial growth factor receptor 20101
Poly [ADP-ribose] polymerase tankyrase-20011
RuvB-like 20112
RuvB-like 10101
ATP-dependent phosphofructokinase1001
NPYLR7B0011
Solute carrier family 22 member 20101
DNA topoisomerase 10101
Hypoxia-inducible factor 1-alpha0112
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
Endothelial PAS domain-containing protein 10011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]