Page last updated: 2024-12-08

spinosyn d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

spinosyn D: a macrolide, structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

spinosyn D : A spinosyn in which the sugar amino and hydroxy groups are globally methylated with an additional methyl substituent attached to the tetracyclic skeleton. One of the two active ingredients of spinosad. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	183094
CHEMBL ID	503450
CHEBI ID	9232
SCHEMBL ID	465825
MeSH ID	M0296063

Synonyms (27)

Synonym
spinosad factor d
spinosyn d
131929-63-0
(2s,3ar,5as,5bs,9s,13s,14r,16as,16bs)-13-{[(2r,5s,6r)-5-(dimethylamino)-6-methyltetrahydro-2h-pyran-2-yl]oxy}-9-ethyl-4,14-dimethyl-7,15-dioxo-2,3,3a,5a,5b,6,7,9,10,11,12,13,14,15,16a,16b-hexadecahydro-1h-as-indaceno[3,2-d]oxacyclododecin-2-yl 6-deoxy-2,3
a 83543d
CHEBI:9232 ,
CHEMBL503450
1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione, 2-((6-deoxy-2,3,4-tri-o- methyl-a-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5- (dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl- 2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl
unii-78g4631rtt
1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione, 2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethy
(2r,3as,5ar,5bs,9s,13s,14r,16as,16br)-2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-4,14-dimethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-1h-as-ind
spinosad factor d [usan]
78g4631rtt ,
1h-as-indaceno(3,2-d)oxacyclododecin-7,15-dione, 2-((6-deoxy-2,3,4-tri-o-methyl-alpha-l-mannopyranosyl)oxy)-13-(((2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl)oxy)-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimet
spinosyn d [mi]
SCHEMBL465825
DTXSID3037599
J-006090
AKOS032946518
(1s,2s,5r,7s,9s,10s,14r,15s,19s)-15-[(2r,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-19-ethyl-4,14-dimethyl-7-[(2r,3r,4r,5s,6s)-3,4,5-trimethoxy-6-methyloxan-2-yl]oxy-20-oxatetracyclo[10.10.0.02,10.05,9]docosa-3,11-diene-13,21-dione
Q27108325
1h-as-indaceno3,2-doxacyclododecin-7,15-dione, 2-(6-deoxy-2,3,4-tri-o-methyl-.alpha.-l-mannopyranosyl)oxy-13-(2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yloxy-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl-, (2
XS175291
spinosyn d 100 microg/ml in acetonitrile
HY-125326
CS-0090359
(2s,3ar,5as,5bs,9s,13s,14r,16as,16bs)-2-[(6-deoxy-2,3,4-tri-o-methyl-?-l-mannopyranosyl)oxy]-13-[[(2r,5s,6r)-5-(dimethylamino)tetrahydro-6-methyl-2h-pyran-2-yl]oxy]-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-4,14-dimethyl-1h-as-indacen

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" Dairy cows were dosed for 28 days with spinosad at rates equivalent to 0, 1, 3, and 10 microg/g in the diet."	( Residues of spinosad in meat, milk, and eggs. Dolder, SC; Gardner, RC; Robb, CK; Rutherford, BS; West, SD, 2000)	0.31

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
pediculicide	Substance used to treat lice (genus Pediculus) infestation.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
spinosyn	A family of macrolide natural products produced by the soil microorganism Saccharopolyspora spinosa.
spinosyn insecticide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID379886	Insecticidal activity against cotton aphid assessed as count of nonwinged stage live aphid after 72 hrs with 24 hrs of photoperiod prior to grading	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Engineering of the spinosyn PKS: directing starter unit incorporation.
AID379887	Insecticidal activity against green peach aphid assessed as count of nonwinged stage live aphid after 72 hrs with 24 hrs of photoperiod prior to grading	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Engineering of the spinosyn PKS: directing starter unit incorporation.
AID379888	Insecticidal activity against sweet potato whitefly assessed as larval survival after 13 days	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Engineering of the spinosyn PKS: directing starter unit incorporation.
AID379892	Insecticidal activity against two-spotted spinder mites assessed as count of live mites after 4 days with low light condition	2006	Journal of natural products, Dec, Volume: 69, Issue:12	Engineering of the spinosyn PKS: directing starter unit incorporation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (26)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (3.85)	18.2507
2000's	13 (50.00)	29.6817
2010's	10 (38.46)	24.3611
2020's	2 (7.69)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 27.81

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	27.81 (24.57)
Research Supply Index	3.30 (2.92)
Research Growth Index	4.72 (4.65)
Search Engine Demand Index	49.16 (26.88)
Search Engine Supply Index	3.00 (0.95)

This Compound (27.81)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.85%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (96.15%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.31	1	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
dimethoate Dimethoate: An organothiophosphorus cholinesterase inhibitor that is used as a systemic and contact insecticide.. dimethoate : A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.	2.21	1	monocarboxylic acid amide; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
malathion Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.	2	1	diester; ethyl ester; organic thiophosphate
nereistoxin nereistoxin: toxin isolated from marine segmented worm, Lumbriconereis heterodopa; RN given refers to parent cpd. nereistoxin : Toxin isolated from marine segmented worm, Lumbriconereis heterodopa. It is also the active insecticide of the proinsecticide thiocyclam.	2.6	1	dithiolanes	insecticide; toxin
titanium Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.	2.1	1	titanium group element atom
rhamnose [no description available]	2.75	3	L-rhamnose
indoxacarb indoxacarb: oxadiazine insecticide; structure in first source. insecticide : Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects.	2.1	1	methyl ester; organochlorine insecticide	voltage-gated sodium channel blocker
forosamine forosamine: from spiramycin; structure	1.99	1	hexosamine; tetradeoxyhexose derivative
spinosyn a spinosyn A: a macrolide ; structure in first source. spinosyn A : A spinosyn in which the sugar amino and hydroxy groups are globally methylated. One of the two active ingredients of spinosad.	5.66	24	spinosyn insecticide; spinosyn	pediculicide
olivose olivose: RN given for (D)-isomer	2.05	1	hexose
dextrothyroxine [no description available]	2.21	1
eosine i bluish Eosine I Bluish: A red fluorescein dye used as a histologic stain. It may be cytotoxic, mutagenic, and inhibit certain mitochondrial functions.	2	1	organic sodium salt	fluorescent dye; histological dye
imidacloprid imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.	2.21	1	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic

Condition	Relationship Strength	Studies
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	2.21	1
Acariasis [description not available]	2.21	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1
Ectoparasitic Infestations Infestations by PARASITES which live on, or burrow into, the surface of their host's EPIDERMIS. Most ectoparasites are ARTHROPODS.	2.92	1

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