Page last updated: 2024-09-27

Blue Nevi

Usually a benign tumor, that commonly presents as a solitary blue nodule with spindled MELANOCYTES covered by smooth SKIN. Several variants have been identified, one variant being malignant. The blue color is caused by large, densely packed melanocytes deep in the DERMIS of the nevus. In CHILDREN, they usually occur on the BUTTOCKS and LUMBOSACRAL REGION and are referred to as cellular blue nevi. Malignant blue nevi are more commonly found on the SCALP.

Synonyms(6)

Synonym
Cellular Blue Nevus
Blue Nevi
Nevus, Blue
Blue Nevus
Blue Nevus, Cellular
Cellular Blue Nevi

Research Excerpts

Overview

Excerpt	Reference
"The malignant blue nevus is an aggressive dermal melanocytic neoplasm."	( English, JC; Grabski, WJ; McCollough, ML, 1996)
"Blue nevi are small acquired melanocytic tumors."	( Bennaceur, S; Berdah, S; Bodemer, C; Chretien-Marquet, B; Fraitag, S; Teillac-Hamel, D, 1996)
"Epithelioid blue nevus is a rare variant of blue nevus that has been recently described in patients with Carney complex."	( de la Cruz, A; Jaqueti, G; Kutzner, H; Moreno, C; Requena, L; Yus, ES, 2000)
"Malignant blue nevus is a very rare tumor."	( Bernard, P; Durlach, A; Gayraud, A; Grosshans, E; Hopfner, C; Lorenzato, M; Mehaut, S; Sartelet, H, 2002)
"Blue nevus is one of the melanotic lesions that can incidentally arise in the prostate gland."	( Dailey, VL; Hameed, O, 2011)
"Blue nevi are a group of congenital and acquired dermal melanocytoses characterized by a blue-gray appearance on the skin."	( Cheng, Y; Ran, Y; Wang, P; Yang, H, 2012)

Context

Excerpt	Reference
"Malignant blue nevus has been described as a distinct identity, a rare form of malignant melanoma, and a misdiagnosed melanoma."	( Chaudhuri, PK; Keil, S; Lineen, A; Micale, M; Thomas, JE; Xue, J; Zyrek-Betts, J, 2008)

Research

Studies (133)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (4.51)	23.3326
1990's	22 (16.54)	12.5806
2000's	38 (28.57)	18.1394
2010's	51 (38.35)	28.8240
2020's	16 (12.03)	9.53

Drug	Relationship Strength	Studies
salicylic acid	low	39
homogentisic acid	low	1
theophylline	low	1
carbamazepine	low	2
pentetic acid	low	1
khellin	low	1
mepivacaine	low	1
oxybutynin	low	1
tranexamic acid	low	1
prednisolone	low	1
benz(a)anthracene	low	1
isoprene	low	3
methylprednisolone	low	2
meglumine	low	2
eosine yellowish-(ys)	low	1
enbucrilate	low	1
silver	low	1
technetium	low	2
argon	low	1
gadolinium	low	1
vindesine	low	1
propiconazole	low	5
imiquimod	low	1
inositol 3-phosphate	low	4
riboflavin	low	1
bromochloroacetic acid	low	1
polidocanol	low	5
phenylephrine hydrochloride	low	3
sirolimus	low	23
gadolinium dtpa	low	1
mart-1 antigen	low	8
dicumarol	low	1
cyclin d1	low	2
muramidase	low	1
folic acid	low	1
dacarbazine	low	1

Protein Targets (694)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
RAR-related orphan receptor gamma	13	0	0	13
GLI family zinc finger 3	11	0	0	11
AR protein	17	0	0	17
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	18	0	0	18
peroxisome proliferator-activated receptor delta	6	0	0	6
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	5	0	0	5
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	11	0	0	11
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	5	0	0	5
Luciferase	2	0	0	2
pregnane X receptor	2	0	0	2
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	6	0	0	6
estrogen-related nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	9	0	0	9
peroxisome proliferator activated receptor gamma	7	0	0	7
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
aryl hydrocarbon receptor	7	0	0	7
thyroid hormone receptor beta isoform 2	6	0	0	6
histone deacetylase 9 isoform 3	1	0	0	1
Cellular tumor antigen p53	13	0	0	13
ATPase family AAA domain-containing protein 5	6	0	0	6
Ataxin-2	6	0	0	6
thyroid stimulating hormone receptor	5	0	0	5
Nuclear receptor ROR-gamma	2	0	0	2
Chain A, Beta-lactamase	2	0	0	2
acetylcholinesterase	3	0	0	3
USP1 protein, partial	8	0	0	8
TDP1 protein	11	0	0	11
thyroid stimulating hormone receptor	6	0	0	6
glucocorticoid receptor [Homo sapiens]	12	0	0	12
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
mitogen-activated protein kinase 1	3	0	0	3
geminin	11	0	0	11
Vpr	2	0	0	2
ATP-binding cassette sub-family C member 3	0	7	0	7
Multidrug resistance-associated protein 4	0	7	0	8
Bile salt export pump	0	2	0	2
Bile salt export pump	0	11	0	11
Albumin	0	0	1	1
Major prion protein	0	0	1	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	6	0	6
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	1	0	2
Cytochrome P450 2J2	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	2	0	2
Frizzled-8	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	7	0	7
P2X purinoceptor 4	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	5	0	0	5
interleukin 8	2	0	0	2
cytochrome P450 2D6	8	0	0	8
survival motor neuron protein isoform d	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
Isocitrate lyase	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
farnesoid X nuclear receptor	4	0	0	4
G	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
cytochrome P450 3A4 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
Interferon beta	6	0	0	6
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Integrin beta-3	2	0	0	2
NAD	0	1	0	1
Cholinesterase	0	1	0	1
Urease	0	1	0	1
Integrin alpha-IIb	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
NAD	0	1	0	2
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Mitogen-activated protein kinase 1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Histamine H2 receptor	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
ATP phosphoribosyltransferase	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Integrase	0	1	0	1
GABA theta subunit	3	0	0	3
Inositol hexakisphosphate kinase 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
G-protein coupled receptor 35	0	1	1	2
cytochrome P450 2C9, partial	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Ferritin light chain	2	0	0	2
acid sphingomyelinase	1	0	0	1
glp-1 receptor, partial	4	0	0	4
glucocerebrosidase	1	0	0	1
alpha-galactosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	2	0	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
EWS/FLI fusion protein	3	0	0	3
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
peripheral myelin protein 22	6	0	0	6
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Adenosine receptor A2a	0	4	2	7
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
GALC protein	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
histone acetyltransferase KAT2A isoform 1	2	0	0	2
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	2	0	2
Cytochrome P450 3A4	0	3	0	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C19	0	3	0	3
Cytochrome P450 1B1	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
PPM1D protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
nonstructural protein 1	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	4	1	10
Glycine receptor subunit alpha-1	0	4	0	4
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
ATP-dependent phosphofructokinase	3	0	0	3
Fumarate hydratase	1	0	0	1
GLS protein	2	0	0	2
polyprotein	1	0	0	1
D(1A) dopamine receptor	1	0	0	1
flap endonuclease 1	2	0	0	2
Amyloid-beta precursor protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	1	4
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Mu-type opioid receptor	0	1	0	1
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Spike glycoprotein	5	0	0	5
Sodium-dependent dopamine transporter	0	2	0	2
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Muscarinic acetylcholine receptor	0	0	1	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
arylsulfatase A	2	0	0	2
Bloom syndrome protein isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
thioredoxin reductase	3	0	0	3
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
chromobox protein homolog 1	2	0	0	2
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
phosphopantetheinyl transferase	3	0	0	3
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
huntingtin isoform 2	1	0	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
DNA polymerase iota isoform a (long)	1	0	0	1
Guanine nucleotide-binding protein G	2	0	0	2
TAR DNA-binding protein 43	2	0	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
NPYLR7B	0	0	1	1
thyrotropin-releasing hormone receptor	1	0	0	1
tumor necrosis factor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	1	0	0	1
lethal factor (plasmid)	2	0	0	2
Riboflavin-binding protein	0	1	1	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Caspase-7	1	0	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	2
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	2
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Smad3	1	0	0	1
67.9K protein	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Tyrosine-protein kinase ABL1	0	0	1	1
Epidermal growth factor receptor	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
High affinity nerve growth factor receptor	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	0	1	1
Cyclin-dependent kinase 1	0	0	1	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
DNA topoisomerase 2-alpha	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Serine/threonine-protein kinase B-raf	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Casein kinase II subunit alpha'	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Multifunctional protein ADE2	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Cyclin-dependent kinase 2	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Myosin-10	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
DNA topoisomerase 2-beta	0	0	1	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Programmed cell death protein 4	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
ATP-dependent RNA helicase DHX30	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Misshapen-like kinase 1	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
Dual specificity testis-specific protein kinase 2	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Target of rapamycin complex subunit LST8	0	1	0	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Serine/threonine-protein kinase ICK	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
transcriptional regulator ERG isoform 3	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Renin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Adenosine receptor A3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Adenosine receptor A1	0	2	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Adenosine receptor A2a	0	1	0	3
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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