Distal Myopathies

A heterogeneous group of genetic disorders characterized by progressive MUSCULAR ATROPHY and MUSCLE WEAKNESS beginning in the hands, the legs, or the feet. Most are adult-onset autosomal dominant forms. Others are autosomal recessive.

Synonym
Distal Myopathies

Excerpt	Reference
"Distal myopathies are rare muscular disorders clinically characterized by a predominantly distal muscular involvement."	( Béhin, A; Bernard, R; Dubourg, O; Eymard, B; Laforêt, P; Lévy, N; Pêcheux, C, 2008)
"Distal myopathies are a group of muscle diseases which share the clinical pattern of predominant weakness in the feet and/or hands."	( Udd, B, 2012)
"Distal myopathies are a group of genetic, primary muscle diseases."	( Jokela, M; Savarese, M; Udd, B, 2023)

Excerpt	Reference
"Distal myopathies have been associated with mutations in titin, dysferlin, GNE, desmin and myosin."	( Carpen, O; Engel, A; Eymard, B; Faulkner, G; Griggs, R; Hackman, P; Haravuori, H; Richard, I; Selcen, D; Talvinen, K; Udd, B; Vihola, A, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	21 (22.58)	18.1394
2010's	44 (47.31)	28.8240
2020's	28 (30.11)	9.53

Drug	Relationship Strength	Studies	Trials
glycine	low	3	0
1-anilino-8-naphthalenesulfonate	low	1	0
flumazenil	low	2	0
metoprolol	low	1	0
nadolol	low	1	0
alanine	low	1	0
serine	low	1	0
adenosine diphosphate	low	1	0
leucine	low	3	0
lactose	low	2	0
methionine	low	1	0
histidine	low	1	0
valine	low	2	0
threonine	low	1	0
isoleucine	low	1	0
arginine	low	2	0
methylprednisolone	low	1	0
tecnazene	low	5	0
pyrazines	low	1	0
uridine diphosphate n-acetylglucosamine	low	1	0
acetylcysteine	low	2	0
mannose	low	1	0
gadolinium	low	1	0
acetylglucosamine	low	1	0
n-acetylneuraminoyllactose	low	1	0
proline	low	7	0
bortezomib	low	1	0
glycogen	low	2	0
n-acetylneuraminic acid	medium	40	7
cytidine monophosphate n-acetylneuraminic acid	low	1	0
n-acetylneuraminoyllactose	medium	2	1
digoxin	low	1	0
cystine	low	1	0
emerin	low	1	0
lactacystin	low	1	0
g(m1) ganglioside	low	1	0
n-acetylmannosamine 6-phosphate	low	1	0
n-acetylmannosamine	medium	7	2
oligonucleotides	low	1	0
calpain	low	3	0
amyloid beta-peptides	low	1	0

Protein Targets (509)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	1	0	0	1
thioredoxin reductase	5	0	0	5
USP1 protein, partial	5	0	0	5
TDP1 protein	7	0	0	7
vitamin D3 receptor isoform VDRA	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
flap endonuclease 1	5	0	0	5
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	2	0	0	2
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
geminin	7	0	0	7
DNA polymerase kappa isoform 1	4	0	0	4
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	4
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
acetylcholinesterase	3	0	0	3
dopamine D1 receptor	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
pregnane X receptor	1	0	0	1
phosphopantetheinyl transferase	4	0	0	4
RAR-related orphan receptor gamma	5	0	0	5
NFKB1 protein, partial	2	0	0	2
Microtubule-associated protein tau	1	0	0	1
Thrombopoietin	1	0	0	1
AR protein	7	0	0	7
regulator of G-protein signaling 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	7	0	0	7
retinoic acid nuclear receptor alpha variant 1	5	0	0	5
retinoid X nuclear receptor alpha	4	0	0	4
farnesoid X nuclear receptor	5	0	0	5
estrogen nuclear receptor alpha	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	6	0	0	6
Bloom syndrome protein isoform 1	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	6	0	0	6
heat shock protein beta-1	2	0	0	2
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
muscarinic acetylcholine receptor M1	4	0	0	4
Histone deacetylase 3	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	4	0	0	4
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	2	0	3
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	1	2
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	1	0	0	1
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	5	0	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Carbonic anhydrase 1	0	1	0	4
Carbonic anhydrase 2	0	1	0	4
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	1	6
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
GLS protein	1	0	0	1
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	4	0	0	4
lethal factor (plasmid)	4	0	0	4
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	2	0	2
Fumarate hydratase	1	0	0	1
PPM1D protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	4	0	0	4
EWS/FLI fusion protein	3	0	0	3
estrogen-related nuclear receptor alpha	8	0	0	8
pregnane X nuclear receptor	6	0	0	6
polyprotein	1	0	0	1
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	6	0	0	6
caspase-3	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Histone H2A.x	2	0	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 1	5	0	0	5
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	2	0	2
ATP-binding cassette sub-family C member 3	0	5	0	5
Multidrug resistance-associated protein 4	0	5	0	5
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Bile salt export pump	0	9	0	9
Prothrombin	0	1	1	2
Chymotrypsinogen A	0	1	0	1
Interferon beta	5	0	0	5
Cellular tumor antigen p53	6	0	0	6
Carbonic anhydrase 3	0	1	0	2
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	1	0	1
Glutamate receptor 2	2	0	0	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	2	0	3
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	1	0	2
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	2	0	2
Proteasome subunit alpha type-2	0	2	0	2
Proteasome subunit alpha type-3	0	2	0	2
Proteasome subunit alpha type-4	0	2	0	2
Proteasome subunit beta type-8	0	2	0	2
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	2	0	2
Proteasome subunit alpha type-5	0	2	0	2
Proteasome subunit beta type-4	0	2	0	2
Proteasome subunit beta type-6	0	2	0	2
Proteasome subunit beta type-5	0	3	0	4
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	2	0	2
Carbonic anhydrase 7	0	1	0	2
26S proteasome regulatory subunit 6B	0	1	0	1
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	2	0	2
Proteasome subunit beta type-2	0	2	0	3
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	2	0	2
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
Carbonic anhydrase 9	0	1	0	2
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	2
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	2	0	2
Canalicular multispecific organic anion transporter 1	0	5	0	5
ATPase family AAA domain-containing protein 5	3	0	0	3
Proteasome subunit beta type-7	0	2	0	2
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	2
Carbonic anhydrase 14	0	1	0	2
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
lamin isoform A-delta10	5	0	0	5
Lactoperoxidase	0	1	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	2	2	6
Gamma-aminobutyric acid receptor subunit beta-1	2	2	2	6
Gamma-aminobutyric acid receptor subunit delta	2	2	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-5	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	2	2	2	6
Gamma-aminobutyric acid receptor subunit gamma-1	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	2	2	2	6
Gamma-aminobutyric acid receptor subunit gamma-3	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-6	2	2	2	6
Gamma-aminobutyric acid receptor subunit alpha-1	2	2	2	6
Gamma-aminobutyric acid receptor subunit beta-3	2	2	2	6
Gamma-aminobutyric acid receptor subunit beta-2	2	2	2	6
GABA theta subunit	2	2	2	6
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	2	2	6
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Beta-galactoside alpha-2,6-sialyltransferase 1	0	0	0	1
Chain A, Beta-lactamase	1	0	0	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	1	0	0	1
PAX8	0	0	0	1
SMAD family member 2	2	0	0	2
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	4	0	0	4
STAT3, partial	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Smad3	1	0	0	1
67.9K protein	1	0	0	1
IDH1	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	2	0	5
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	6
Integrin alpha-IIb	1	0	0	1
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Nuclear receptor ROR-gamma	1	1	1	3
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	3
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	2
Solute carrier organic anion transporter family member 1B1	0	1	0	3
endonuclease IV	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
G	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	0	2	0	2
Gamma-aminobutyric acid receptor subunit delta	0	2	0	2
Bile salt export pump	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
TAR DNA-binding protein 43	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	0	2
Inositol hexakisphosphate kinase 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit theta	0	2	0	2
cytochrome P450 2C9, partial	3	0	0	3
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2B	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	2	1	4
Large neutral amino acids transporter small subunit 1	0	6	0	6
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
Plasma kallikrein	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Adenosine receptor A1	0	0	0	1
Adenosine receptor A2a	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
nonstructural protein 1	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	2	0	2
Glycine receptor subunit alpha-1	0	2	0	2
Androgen receptor	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	2	4
Beta-1 adrenergic receptor	0	2	1	3
Cytochrome P450 2D6	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Sialidase-4	0	1	0	1
Sialidase-1	0	1	0	1
Sialidase-3	0	1	0	1
Sialidase-2	0	1	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Amino acid transporter	0	2	0	2
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
apical membrane antigen 1, AMA1	2	0	0	2
aryl hydrocarbon receptor	2	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Rap guanine nucleotide exchange factor 3	1	0	0	1
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 1A3	0	0	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
glp-1 receptor, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Androgen receptor	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Adenosine receptor A1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (93)

Protein Targets (509)

Distal Myopathies

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (93)

Drugs Studied (48)

Protein Targets (509)