Paralysis, Sleep

A common condition characterized by transient partial or total paralysis of skeletal muscles and areflexia that occurs upon awakening from sleep or less often while falling asleep. Stimuli such as touch or sound may terminate the episode, which usually has a duration of seconds to minutes. This condition may occur in normal subjects or be associated with NARCOLEPSY; CATAPLEXY; and hypnagogic HALLUCINATIONS. The pathophysiology of this condition is closely related to the normal hypotonia that occur during REM sleep. (From Adv Neurol 1995;67:245-271)

Synonym
Sleep Paralysis
Paralysis, Sleep

Excerpt	Reference
"Sleep paralysis is a state of involuntary immobility occurring at sleep onset or offset, often accompanied by uncanny "ghost-like" hallucinations and extreme fear reactions."	( Jalal, B, 2018)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (6.67)	23.3326
1990's	0 (0.00)	12.5806
2000's	8 (53.33)	18.1394
2010's	3 (20.00)	28.8240
2020's	3 (20.00)	9.53

Drug	Relationship Strength	Studies
gamma-aminobutyric acid	low	1
urea	low	1
carbamazepine	low	1
citalopram	low	1
clomipramine	low	1
diazepam	low	1
imipramine	low	1
mazindol	low	1
methylphenidate	low	1
modafinil	low	3
primidone	low	1
risperidone	low	1
lysergic acid diethylamide	low	1
psilocybin	low	1
paroxetine	low	1
aripiprazole	low	1
mdl 100907	low	1
fluvoxamine	low	1
pimavanserin	low	1
sodium oxybate	low	3
piperidines	low	1

Protein Targets (472)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
thioredoxin reductase	5	0	0	5
ATAD5 protein, partial	4	0	0	4
TDP1 protein	11	0	0	11
Microtubule-associated protein tau	3	0	0	3
estrogen-related nuclear receptor alpha	11	0	0	11
arylsulfatase A	5	0	0	5
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	3	0	0	3
D(1A) dopamine receptor	9	0	0	9
lamin isoform A-delta10	7	0	0	7
neuropeptide S receptor isoform A	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
5-hydroxytryptamine receptor 3E	0	2	1	4
acetylcholinesterase	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
RAR-related orphan receptor gamma	6	0	0	6
SMAD family member 2	1	0	0	1
Fumarate hydratase	3	0	0	3
USP1 protein, partial	7	0	0	7
PPM1D protein	2	0	0	2
SMAD family member 3	1	0	0	1
GLI family zinc finger 3	11	0	0	11
AR protein	12	0	0	12
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	8	0	0	8
progesterone receptor	6	0	0	6
EWS/FLI fusion protein	6	0	0	6
glucocorticoid receptor [Homo sapiens]	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	9	0	0	9
retinoid X nuclear receptor alpha	5	0	0	5
farnesoid X nuclear receptor	3	0	0	3
pregnane X nuclear receptor	8	0	0	8
estrogen nuclear receptor alpha	12	0	0	12
G	8	0	0	8
cytochrome P450 2D6	12	0	0	12
polyprotein	3	0	0	3
67.9K protein	1	0	0	1
peroxisome proliferator-activated receptor delta	3	0	0	3
peroxisome proliferator activated receptor gamma	5	0	0	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
thyroid stimulating hormone receptor	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transcriptional regulator ERG isoform 3	3	0	0	3
thyroid hormone receptor beta isoform 2	9	0	0	9
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
nuclear receptor ROR-gamma isoform 1	2	0	0	2
geminin	5	0	0	5
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	3	0	0	3
5-hydroxytryptamine receptor 2A	0	0	1	1
Solute carrier family 22 member 2	0	4	0	4
ATP-binding cassette sub-family C member 3	0	9	0	9
Multidrug resistance-associated protein 4	0	9	0	9
5-hydroxytryptamine receptor 3A	0	1	1	2
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
5-hydroxytryptamine receptor 3B	0	2	1	4
Bile salt export pump	0	10	0	10
Interferon beta	9	0	0	9
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	9	0	0	9
ATP-dependent translocase ABCB1	0	3	0	5
Cytochrome P450 3A4	0	4	0	5
5-hydroxytryptamine receptor 1A	0	6	4	10
5-hydroxytryptamine receptor 2C	0	9	0	9
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
D(2) dopamine receptor	0	13	1	14
5-hydroxytryptamine receptor 2A	0	10	1	11
Alpha-1B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	5	0	5
D	0	5	0	5
5-hydroxytryptamine receptor 1A	0	11	1	12
Glutamate receptor 2	4	0	0	4
Muscarinic acetylcholine receptor M3	0	7	0	7
D(1A) dopamine receptor	0	5	0	5
D(4) dopamine receptor	0	5	0	5
D(1B) dopamine receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	7	0	7
Alpha-1D adrenergic receptor	0	7	0	7
5-hydroxytryptamine receptor 2A	0	14	3	18
5-hydroxytryptamine receptor 2C	0	15	1	16
D(4) dopamine receptor	0	4	0	4
Histamine H1 receptor	0	2	0	2
Sodium-dependent serotonin transporter	0	19	2	21
5-hydroxytryptamine receptor 7	0	6	0	6
5-hydroxytryptamine receptor 7	0	5	0	5
Alpha-1A adrenergic receptor	0	4	0	4
Histamine H1 receptor	0	13	0	13
Alpha-1B adrenergic receptor	0	2	0	2
D(3) dopamine receptor	0	8	1	9
5-hydroxytryptamine receptor 2B	0	14	1	15
Alpha-1A adrenergic receptor	0	8	0	8
5-hydroxytryptamine receptor 3A	0	3	1	5
5-hydroxytryptamine receptor 6	0	6	0	7
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Spike glycoprotein	9	0	1	10
D(2) dopamine receptor	0	7	0	7
Inositol monophosphatase 1	3	0	0	3
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
5-hydroxytryptamine receptor 3D	0	2	1	4
Multidrug and toxin extrusion protein 2	0	4	0	4
5-hydroxytryptamine receptor 3C	0	2	1	4
Inositol hexakisphosphate kinase 1	8	0	0	8
Canalicular multispecific organic anion transporter 1	0	8	0	8
Multidrug and toxin extrusion protein 1	0	4	0	4
Histamine H3 receptor	0	2	0	2
cytochrome P450 2C9, partial	8	0	0	8
GLS protein	5	0	0	5
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
Neuronal acetylcholine receptor subunit beta-2	0	4	0	5
UDP-glucuronosyltransferase 1-6	0	1	0	1
Cytochrome P450 2B6	0	0	1	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium-dependent noradrenaline transporter	0	17	1	18
Sodium-dependent dopamine transporter	0	12	0	12
Neuronal acetylcholine receptor subunit beta-4	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Cytochrome P450 2C19	0	3	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	3	0	4
Sodium-dependent dopamine transporter	0	16	1	18
Acetylcholine receptor subunit delta	0	1	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, Beta-lactamase	1	0	0	1
thyroid stimulating hormone receptor	6	0	0	6
IDH1	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	6	0	0	6
thyroid hormone receptor beta isoform a	2	0	0	2
mitogen-activated protein kinase 1	3	0	0	3
Vpr	1	0	0	1
Bile salt export pump	0	1	0	1
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	4	0	4
Sodium channel protein type 4 subunit alpha	0	2	0	3
Cytochrome P450 2J2	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
aldehyde dehydrogenase 1 family, member A1	3	0	0	3
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
survival motor neuron protein isoform d	3	0	0	3
Solute carrier family 22 member 1	0	5	0	5
Sodium-dependent noradrenaline transporter	0	3	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Aldo-keto reductase family 1 member B1	0	8	0	8
Tryptophan 5-hydroxylase 1	0	3	0	3
Angiotensin-converting enzyme	0	6	0	6
Aldo-keto reductase family 1 member B1	0	2	0	2
Acetylcholinesterase	0	1	0	1
Aromatase	0	1	0	1
Sodium-dependent serotonin transporter	0	10	1	11
5-hydroxytryptamine receptor 7	0	4	0	4
Sigma intracellular receptor 2	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	3
Sodium-dependent dopamine transporter	0	5	0	5
Nuclear receptor subfamily 3 group C member 3	0	6	0	6
Ataxin-2	7	0	0	7
Sigma non-opioid intracellular receptor 1	0	10	0	10
Sigma non-opioid intracellular receptor 1	0	5	0	5
Transporter	0	11	0	11
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Thrombopoietin	1	0	0	1
caspase 7, apoptosis-related cysteine protease	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
caspase-3	3	0	0	3
Histone H2A.x	4	0	0	4
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
chromobox protein homolog 1	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	3	0	0	3
cytochrome P450 3A4 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	4	0	0	4
lethal factor (plasmid)	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	7	2	11
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	5	0	5
Muscarinic acetylcholine receptor M5	0	5	0	5
Alpha-2A adrenergic receptor	0	4	0	4
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Cytochrome P450 2D6	0	7	0	7
Muscarinic acetylcholine receptor M1	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	2	7	2	11
Alpha-2B adrenergic receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit delta	2	7	2	11
Gamma-aminobutyric acid receptor subunit gamma-2	2	7	3	12
Alpha-2B adrenergic receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-5	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-3	2	7	2	11
Alpha-2C adrenergic receptor	0	5	0	5
Alpha-2A adrenergic receptor	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	2	7	2	11
Gamma-aminobutyric acid receptor subunit alpha-2	2	7	2	11
Histamine H2 receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	2	7	2	11
Gamma-aminobutyric acid receptor subunit gamma-3	2	7	2	11
5-hydroxytryptamine receptor 1B	0	6	0	6
5-hydroxytryptamine receptor 1D	0	4	0	4
Trypanothione reductase	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	7	2	11
5-hydroxytryptamine receptor 1F	0	4	0	4
5-hydroxytryptamine receptor 2B	0	8	0	8
5-hydroxytryptamine receptor 6	0	3	0	3
Histamine H1 receptor	0	3	0	3
5-hydroxytryptamine receptor 5A	0	3	0	3
5-hydroxytryptamine receptor 5B	0	3	0	3
5-hydroxytryptamine receptor 3A	0	5	1	6
Trypanothione reductase	0	1	0	1
Histamine H2 receptor	2	2	0	5
D(1A) dopamine receptor	3	0	0	3
Proteasome subunit alpha type-6	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	7	3	12
Gamma-aminobutyric acid receptor subunit beta-3	2	7	2	11
Gamma-aminobutyric acid receptor subunit beta-2	2	7	3	12
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Envelope glycoprotein	0	0	3	3
5-hydroxytryptamine receptor 4	0	3	0	3
GABA theta subunit	2	7	2	11
Angiotensin-converting enzyme 2	0	0	1	1
Gamma-aminobutyric acid receptor subunit epsilon	2	7	2	11
5-hydroxytryptamine receptor 3B	0	5	1	6
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Fatty acid-binding protein, liver	0	1	0	1
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	0	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	4	4	8
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	2	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	3	7
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	4	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
ATPase family AAA domain-containing protein 5	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Luciferase	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
activating transcription factor 6	4	0	0	4
Cytochrome P450 1A2	0	1	0	1
D(3) dopamine receptor	0	4	0	4
D(1B) dopamine receptor	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Chain A, Ferritin light chain	2	0	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
regulator of G-protein signaling 4	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Histone deacetylase 3	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
TAR DNA-binding protein 43	2	0	0	2
Histone deacetylase 1	0	1	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Snq2p	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Sphingomyelin phosphodiesterase	0	1	0	1
Pleiotropic ABC efflux transporter of multiple drugs	0	1	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
D(2) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
aryl hydrocarbon receptor	1	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
D	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
Transporter	0	2	0	2
Integrin beta-3	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Integrin alpha-IIb	0	1	0	1
Beta-2 adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Interleukin-6 receptor subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Beta-3 adrenergic receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
ras-related protein Rab-9A	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Myeloperoxidase	0	1	0	1
Quinolone resistance protein NorA	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
P2X purinoceptor 4	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
dopamine D1 receptor	1	0	0	1
pregnane X receptor	1	0	0	1
DNA polymerase beta	1	0	0	1
flap endonuclease 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Smad3	1	0	0	1
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C19 precursor	1	0	0	1
Glycine receptor subunit alpha-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (15)

Protein Targets (472)

Paralysis, Sleep

Synonyms(2)

Research Excerpts

Overview

Research

Studies (15)

Drugs Studied (24)

Protein Targets (472)