Page last updated: 2024-09-27

Hand-Arm Vibration Syndrome

An occupational disorder resulting from prolonged exposure to vibration, affecting the fingers, hands, and forearms. It occurs in workers who regularly use vibrating tools such as jackhammers, power chain saws, riveters, etc. Symptoms include episodic finger blanching, NUMBNESS, tingling, and loss of nerve sensitivity.

Synonyms(1)

Synonym
Hand-Arm Vibration Syndrome

Research

Studies (69)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's17 (24.64)18.1394
2010's35 (50.72)28.8240
2020's17 (24.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium22
benzene0low10
thioctic acid0medium11
methanol0low10
nitrous oxide0low10
etidronate0low10
gabapentin0medium22
lidocaine0low10
nifedipine0low10
pentoxifylline0low10
prilocaine0low10
phenylephrine0low10
tyrosine0low10
vinyl chloride0low10
gold0low10
ng-nitroarginine methyl ester0low10
telmisartan0low10
nicotine0low10
3-nitrotyrosine0low10
myelin basic protein0low10
psd 5020low10
endothelin-10low10
vendex0low10
exudates0low120

Protein Targets (495)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, JmjC domain-containing histone demethylation protein 3A3003
phosphopantetheinyl transferase3003
bromodomain adjacent to zinc finger domain 2B4004
euchromatic histone-lysine N-methyltransferase 2120012
pyruvate kinase PKM isoform a1001
geminin6006
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G2002
Tubulin--tyrosine ligase0202
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor2002
thyroid stimulating hormone receptor8008
progesterone receptor2002
retinoid X nuclear receptor alpha4004
peroxisome proliferator-activated receptor delta3003
cellular tumor antigen p53 isoform a2002
Endolysin0011
Cellular tumor antigen p534004
Integrin beta-32002
Integrin alpha-IIb2002
Endothelin-1 receptor0101
acid sphingomyelinase1001
GLI family zinc finger 34004
apical membrane antigen 1, AMA11001
retinoic acid nuclear receptor alpha variant 14004
farnesoid X nuclear receptor3003
estrogen nuclear receptor alpha7007
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
IDH14004
aryl hydrocarbon receptor3003
DNA polymerase iota isoform a (long)3003
peripheral myelin protein 224004
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta108008
Voltage-dependent calcium channel gamma-2 subunit2002
Bile salt export pump0707
Glutamate receptor 23003
USP1 protein, partial3003
thioredoxin glutathione reductase1001
aldehyde dehydrogenase 1 family, member A17007
regulator of G-protein signaling 45005
EWS/FLI fusion protein4004
glucocorticoid receptor [Homo sapiens]3003
Bloom syndrome protein isoform 14004
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
survival motor neuron protein isoform d3003
muscarinic acetylcholine receptor M14004
Voltage-dependent calcium channel subunit alpha-2/delta-10101
ATP-dependent phosphofructokinase4004
Chain A, Ferritin light chain1001
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
thioredoxin reductase8008
ATAD5 protein, partial3003
Hsf1 protein0011
arylsulfatase A5005
D(1A) dopamine receptor4004
thyroid hormone receptor beta isoform a2002
transcriptional regulator ERG isoform 31001
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
neuropeptide S receptor isoform A2002
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit pi3205
Gamma-aminobutyric acid receptor subunit delta0101
Histone deacetylase 30101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-13205
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit delta3205
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-23216
Gamma-aminobutyric acid receptor subunit alpha-53205
Gamma-aminobutyric acid receptor subunit alpha-33205
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Gamma-aminobutyric acid receptor subunit gamma-13205
Gamma-aminobutyric acid receptor subunit alpha-23205
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit alpha-43205
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit gamma-33205
Gamma-aminobutyric acid receptor subunit rho-20011
Gamma-aminobutyric acid receptor subunit alpha-63205
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit alpha-13216
Gamma-aminobutyric acid receptor subunit beta-33205
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit beta-23216
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
TAR DNA-binding protein 434004
Histone deacetylase 10101
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
GABA theta subunit3205
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Gamma-aminobutyric acid receptor subunit gamma-30101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit epsilon3205
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Gamma-aminobutyric acid type B receptor subunit 10011
Histone deacetylase 90101
Gamma-aminobutyric acid receptor subunit theta0101
Histone deacetylase 50101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain A, Beta-lactamase3003
RAR-related orphan receptor gamma4004
GLS protein2002
TDP1 protein4004
Microtubule-associated protein tau3003
AR protein5005
vitamin D (1,25- dihydroxyvitamin D3) receptor3003
chromobox protein homolog 14004
mitogen-activated protein kinase 13003
flap endonuclease 12002
cytochrome P450 3A4 isoform 13003
Potassium channel subfamily K member 30101
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40505
Potassium channel subfamily K member 20112
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50202
Sodium channel protein type 4 subunit alpha0202
Potassium voltage-gated channel subfamily H member 20303
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0202
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Canalicular multispecific organic anion transporter 10505
Multidrug and toxin extrusion protein 10202
Sodium channel protein type 3 subunit alpha0202
thyroid hormone receptor beta isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 15005
lethal factor (plasmid)1001
Neutrophil elastase0101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, endothelial0101
Nitric oxide synthase, brain0101
Nitric oxide synthase, inducible0101
Nitric oxide synthase, inducible0101
Collagenase 30101
5-hydroxytryptamine receptor 3E0101
interleukin 81001
hypoxia-inducible factor 1 alpha subunit2002
Smad32002
Solute carrier family 22 member 1 0001
Neuronal acetylcholine receptor subunit alpha-40213
Transient receptor potential cation channel subfamily A member 10011
5-hydroxytryptamine receptor 3B0101
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit alpha0213
Acetylcholine receptor subunit beta0213
Acetylcholine receptor subunit gamma0213
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-30225
Cytochrome P450 1A20202
Acetylcholine receptor subunit gamma0213
Muscarinic acetylcholine receptor M10101
Muscarinic acetylcholine receptor M30101
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40202
Muscarinic acetylcholine receptor M50101
Neuronal acetylcholine receptor subunit alpha-40101
Neuronal acetylcholine receptor subunit alpha-40225
Muscarinic acetylcholine receptor M20101
Acetylcholine receptor subunit beta0213
Cytochrome P450 2A60213
Neuronal acetylcholine receptor subunit alpha-20225
Neuronal acetylcholine receptor subunit beta-20225
Neuronal acetylcholine receptor subunit beta-30225
Neuronal acetylcholine receptor subunit beta-40225
Translocator protein0101
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-50225
Cytochrome P450 2A50101
Acetylcholine receptor subunit beta-like 20202
Neuronal acetylcholine receptor subunit alpha-50011
Neuronal acetylcholine receptor subunit beta-40213
Muscarinic acetylcholine receptor M40101
Neuronal acetylcholine receptor subunit alpha-30213
Delta-type opioid receptor0101
Delta-type opioid receptor0101
Mu-type opioid receptor0101
Neuronal acetylcholine receptor subunit alpha-70224
Neuronal acetylcholine receptor subunit alpha-60225
Neuronal acetylcholine receptor subunit alpha-90225
Neuronal acetylcholine receptor subunit alpha-40213
5-hydroxytryptamine receptor 3A0101
Neuronal acetylcholine receptor subunit alpha-70202
Nuclear receptor ROR-gamma3003
Acetylcholine-binding protein0112
Mu-type opioid receptor0101
Inositol monophosphatase 13003
Acetylcholine receptor subunit epsilon0011
Neuronal acetylcholine receptor subunit beta-30112
Neuronal acetylcholine receptor subunit alpha-70225
Acetylcholine receptor subunit delta0213
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit alpha-60112
Cytochrome P450 2A130112
Neuronal acetylcholine receptor subunit alpha-50202
Liver carboxylesterase B-10101
Solute carrier family 22 member 10101
5-hydroxytryptamine receptor 3D0101
Transient receptor potential cation channel subfamily A member 10022
Neuronal acetylcholine receptor subunit beta-30202
Neuronal acetylcholine receptor subunit beta-40202
Neuronal acetylcholine receptor subunit alpha-30202
Soluble acetylcholine receptor0101
5-hydroxytryptamine receptor 3C0101
Neuronal acetylcholine receptor subunit alpha-20202
Neuronal acetylcholine receptor subunit beta-20213
Neuronal acetylcholine receptor subunit alpha-100225
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-60202
Integrin beta0011
Glycoprotein IIb0011
Transporter0113
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase2002
Luciferase3003
Fumarate hydratase1001
NFKB1 protein, partial3003
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)2002
hypothetical protein, conserved1001
nuclear receptor subfamily 1, group I, member 32002
cytochrome P450 family 3 subfamily A polypeptide 42002
nonstructural protein 11001
estrogen-related nuclear receptor alpha2002
pregnane X nuclear receptor3003
G2002
cytochrome P450 2D63003
polyprotein1001
67.9K protein1001
Parkin1001
peroxisome proliferator activated receptor gamma3003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
beta-2 adrenergic receptor1001
cytochrome P450 2D6 isoform 11001
peripheral myelin protein 22 isoform 12002
tumor necrosis factor1001
polyunsaturated fatty acid lipoxygenase ALOX121001
cytochrome P450 2C19 precursor1001
cytochrome P450 2C9 precursor1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
perilipin-50101
vitamin D3 receptor isoform VDRA3003
perilipin-10101
heat shock protein beta-11001
atrial natriuretic peptide receptor 2 precursor1001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
eyes absent homolog 2 isoform a2002
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 12002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0202
Bile salt export pump0101
5-hydroxytryptamine receptor 40202
Glutathione reductase, mitochondrial0202
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Muscarinic acetylcholine receptor M20001
Muscarinic acetylcholine receptor M40001
ATP-dependent translocase ABCB10101
Muscarinic acetylcholine receptor M50001
Adenosine receptor A30202
Muscarinic acetylcholine receptor M10001
Cytochrome P450 2C9 0202
Polyunsaturated fatty acid lipoxygenase ALOX150101
Phospholipase A2, membrane associated0001
5-hydroxytryptamine receptor 2A0202
Alpha-1B adrenergic receptor0303
Muscarinic acetylcholine receptor M30001
Voltage-dependent L-type calcium channel subunit alpha-1C0202
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Thromboxane-A synthase 0101
Platelet-activating factor receptor0001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
5-hydroxytryptamine receptor 2C0202
Indoleamine 2,3-dioxygenase 10101
Adenosine receptor A2a0101
Adenosine receptor A10202
Adenosine receptor A2a0102
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Sodium channel protein type 1 subunit alpha0101
C-C chemokine receptor type 20202
Alpha-1A adrenergic receptor0303
Histamine H2 receptor1001
Cytochrome P450 2J20303
Spike glycoprotein2002
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Potassium voltage-gated channel subfamily A member 10101
C-terminal-binding protein 11001
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0203
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Leukotriene B4 receptor 10001
Myosin light chain kinase, smooth muscle0101
Potassium channel subfamily K member 2 0101
Beta-2 adrenergic receptor0001
Indoleamine 2,3-dioxygenase 20101
Inositol hexakisphosphate kinase 12002
ATPase family AAA domain-containing protein 51001
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Sodium channel protein type 2 subunit alpha0101
Ataxin-21001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Leukotriene B4 receptor 20001
Sodium channel protein type 11 subunit alpha0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial2002
endonuclease IV1001
dopamine D1 receptor2002
vasopressin V1b receptor1001
relaxin receptor 1 isoform 11001
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
Tumor necrosis factor0101
Cholinesterase0202
Acetylcholinesterase0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Adenosine receptor A2b0101
Disintegrin and metalloproteinase domain-containing protein 172002
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Chitotriosidase-10213
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Endochitinase B10213
glp-1 receptor, partial1001
Alpha-1B adrenergic receptor 0011
ras-related protein Rab-9A1001
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0011
Alpha-2A adrenergic receptor0112
Beta-3 adrenergic receptor0011
POU domain, class 2, transcription factor 10001
Alpha-2B adrenergic receptor0101
Beta-1 adrenergic receptor0101
Alpha-1A adrenergic receptor0112
Alpha-2C adrenergic receptor0112
Alpha-1B adrenergic receptor0101
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Alpha-2B adrenergic receptor0001
Alpha-1A adrenergic receptor0112
Alpha-1B adrenergic receptor0112
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
SMAD family member 22002
SMAD family member 32002
activating transcription factor 61001
nuclear factor erythroid 2-related factor 2 isoform 22002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
Angiotensin-converting enzyme 0101
Cystic fibrosis transmembrane conductance regulator0011
Amine oxidase [flavin-containing] A 0011
Thromboxane A2 receptor 0001
Peroxisome proliferator-activated receptor alpha0011
Glycine receptor subunit alpha-10011
Type-1 angiotensin II receptor0102
Peroxisome proliferator-activated receptor delta0011
Peroxisome proliferator-activated receptor gamma0112
Peroxisome proliferator-activated receptor gamma0011
Type-2 angiotensin II receptor0101
Peroxisome proliferator-activated receptor delta0112
Peroxisome proliferator-activated receptor alpha0112
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
acetylcholinesterase1001
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
hexokinase0101
DNA polymerase beta1001
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
DNA polymerase kappa isoform 12002
Vif0101
Tat0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 10101
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0101
Aldo-keto reductase family 1 member B10101
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Carbonic anhydrase 10001
Carbonic anhydrase 20001
Plasma kallikrein0001
Carbonic anhydrase 30001
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Adenosine receptor A10001
Carbonic anhydrase 5A, mitochondrial0001
Glutamate receptor ionotropic, NMDA 1 0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]