Page last updated: 2024-09-27

Kluver-Bucy Syndrome

A neurobehavioral syndrome associated with bilateral medial temporal lobe dysfunction. Clinical manifestations include oral exploratory behavior; tactile exploratory behavior; hypersexuality; BULIMIA; MEMORY DISORDERS; placidity; and an inability to recognize objects or faces. This disorder may result from a variety of conditions, including CRANIOCEREBRAL TRAUMA; infections; ALZHEIMER DISEASE; PICK DISEASE OF THE BRAIN; and CEREBROVASCULAR DISORDERS.

Synonyms(2)

Synonym
Temporal Lobectomy Behavior Syndrome
Kluver-Bucy Syndrome

Research

Studies (21)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's11 (52.38)18.1394
2010's9 (42.86)28.8240
2020's1 (4.76)9.53
DrugIndicatedRelationship StrengthStudiesTrials
bupropion0low10
ibotenic acid0low10
carbamazepine0low60
clonidine0low20
haloperidol0low10
methylphenidate0low10
risperidone0low20
s,n,n'-tripropylthiocarbamate0low10
cresyl violet0low10
fluorodeoxyglucose f180low10
sertraline0low10
methotrexate0low20
trimethoprim, sulfamethoxazole drug combination0low10
humulene0low10
fluvoxamine0low10
technetium tc 99m exametazime0low10
ro13-99040low10
acyclovir0low20
ego0low10

Protein Targets (449)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain E, Purine nucleoside phosphorylase0101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
Chain A, Ferritin light chain3003
Thymidine kinase 0101
thioredoxin reductase5005
phosphopantetheinyl transferase4004
GLS protein3003
TDP1 protein7007
Smad33003
thyroid stimulating hormone receptor4004
EWS/FLI fusion protein4004
arylsulfatase A5005
euchromatic histone-lysine N-methyltransferase 25005
activating transcription factor 62002
Histone H2A.x2002
Bloom syndrome protein isoform 12002
hemoglobin subunit beta1001
atrial natriuretic peptide receptor 1 precursor1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
lamin isoform A-delta105005
Solute carrier family 22 member 1 0305
ATP-binding cassette sub-family C member 30505
Multidrug resistance-associated protein 40506
Solute carrier family 22 member 60001
Bile salt export pump0303
Bile salt export pump0707
Purine nucleoside phosphorylase0101
Thymidine kinase, cytosolic0001
POU domain, class 2, transcription factor 20001
Cytochrome P450 2C9 0505
Cytochrome P450 2J20404
Disintegrin and metalloproteinase domain-containing protein 171001
Purine nucleoside phosphorylase0011
Solute carrier family 22 member 60002
Thymidine kinase 0101
Solute carrier family 22 member 80002
Canalicular multispecific organic anion transporter 10505
Thymidine kinase0101
USP1 protein, partial4004
D(1A) dopamine receptor4004
histone acetyltransferase KAT2A isoform 12002
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70204
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60101
Cytochrome P450 2B60013
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40102
Sodium-dependent noradrenaline transporter 0819
Sodium-dependent dopamine transporter0505
Neuronal acetylcholine receptor subunit beta-40102
Sodium-dependent serotonin transporter011112
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C190202
UDP-glucuronosyltransferase 2B10 0101
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Sodium-dependent dopamine transporter 0718
Acetylcholine receptor subunit delta0101
ATP-dependent phosphofructokinase4004
Chain A, Beta-lactamase3003
acetylcholinesterase4004
RAR-related orphan receptor gamma2002
AR protein6006
glucocorticoid receptor [Homo sapiens]3003
retinoic acid nuclear receptor alpha variant 13003
estrogen-related nuclear receptor alpha6006
pregnane X nuclear receptor3003
estrogen nuclear receptor alpha6006
IDH13003
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
thyroid hormone receptor beta isoform a2002
nuclear factor erythroid 2-related factor 2 isoform 22002
mitogen-activated protein kinase 11001
geminin4004
Vpr1001
Albumin0033
Major prion protein0022
Cellular tumor antigen p532002
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 4 subunit alpha0203
Potassium voltage-gated channel subfamily H member 20808
Sodium channel protein type 9 subunit alpha0303
Frizzled-80011
P2X purinoceptor 40101
Chain A, Cruzipain1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nuclear receptor subfamily 1, group I, member 34004
regulator of G-protein signaling 43003
cytochrome P450 2D64004
Beta-1 adrenergic receptor 0011
Alpha-1B adrenergic receptor 0011
cytochrome P450 2D6 isoform 13003
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
muscarinic acetylcholine receptor M13003
Membrane primary amine oxidase 0101
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30202
5-hydroxytryptamine receptor 1A0426
Alpha-2A adrenergic receptor0819
Alpha-1B adrenergic receptor0404
Alpha-2B adrenergic receptor0819
Alpha-1A adrenergic receptor0011
Alpha-2C adrenergic receptor0819
D0606
D(3) dopamine receptor0606
5-hydroxytryptamine receptor 1A0606
Alpha-2B adrenergic receptor0404
Amine oxidase [flavin-containing] A0101
Alpha-2C adrenergic receptor0404
Alpha-2A adrenergic receptor0404
Alpha-1D adrenergic receptor0404
Alpha-1D adrenergic receptor0617
D(1B) dopamine receptor0505
Amine oxidase [flavin-containing] B0101
5-hydroxytryptamine receptor 1B0505
Adenosine receptor A2b0011
Adenosine receptor A2a0011
Alpha-2B adrenergic receptor0001
D(4) dopamine receptor0505
Delta-type opioid receptor0101
Alpha-1A adrenergic receptor0415
Alpha-1B adrenergic receptor0314
Alpha-1A adrenergic receptor0415
Histamine H2 receptor2003
5-hydroxytryptamine receptor 70202
Spike glycoprotein5005
D(2) dopamine receptor0707
Mu-type opioid receptor0101
Inositol monophosphatase 12002
Alpha-2C adrenergic receptor0001
Alpha-2A adrenergic receptor0001
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10202
Nischarin0101
GLI family zinc finger 32002
estrogen receptor 2 (ER beta)2002
progesterone receptor3003
cytochrome P450 family 3 subfamily A polypeptide 42002
retinoid X nuclear receptor alpha2002
G1001
thyroid stimulating hormone receptor3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
potassium voltage-gated channel subfamily H member 2 isoform d3003
thyroid hormone receptor beta isoform 23003
nuclear factor erythroid 2-related factor 2 isoform 14004
survival motor neuron protein isoform d3003
Voltage-dependent calcium channel gamma-2 subunit4004
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 1001
Cytochrome P450 1A2 0101
Tryptophan 5-hydroxylase 10101
Cytochrome P450 2D60303
Glutamate receptor 24105
Sodium-dependent serotonin transporter0303
Sodium channel protein type 5 subunit alpha0303
Sigma intracellular receptor 20303
Inositol hexakisphosphate kinase 11001
Ataxin-24004
Sigma non-opioid intracellular receptor 10505
Sigma non-opioid intracellular receptor 10404
Transporter0303
cytochrome P450 2C9, partial1001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE3003
glp-1 receptor, partial2002
15-lipoxygenase, partial2002
ATAD5 protein, partial3003
Fumarate hydratase2002
NFKB1 protein, partial1001
Thrombopoietin1001
caspase 7, apoptosis-related cysteine protease1001
nonstructural protein 12002
farnesoid X nuclear receptor2002
polyprotein2002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta2002
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-31001
Adenylate cyclase type 1 0101
peripheral myelin protein 22 isoform 12002
serine/threonine-protein kinase mTOR isoform 12002
nuclear receptor ROR-gamma isoform 11001
peripheral myelin protein 224004
cytochrome P450 3A4 isoform 11001
transient receptor potential cation channel subfamily V member 11001
lethal factor (plasmid)1001
Cocaine esterase0101
Gamma-aminobutyric acid receptor subunit pi1001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
UDP-glucuronosyltransferase 1A90102
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40606
Potassium channel subfamily K member 20101
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10305
Muscarinic acetylcholine receptor M10202
Muscarinic acetylcholine receptor M30202
Muscarinic acetylcholine receptor M40202
Cytochrome P450 3A40304
5-hydroxytryptamine receptor 2C0506
Muscarinic acetylcholine receptor M50202
Muscarinic acetylcholine receptor M50505
Beta-2 adrenergic receptor0202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M10505
Angiotensin-converting enzyme0505
Integrin alpha-40101
D(2) dopamine receptor0417
5-hydroxytryptamine receptor 2A0505
Gamma-aminobutyric acid receptor subunit beta-11001
Carbonyl reductase [NADPH] 10001
Beta-1 adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
D(2) dopamine receptor0202
Muscarinic acetylcholine receptor M30303
D(1A) dopamine receptor0405
D(4) dopamine receptor0316
D(1B) dopamine receptor0203
Adenylate cyclase type 30101
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
5-hydroxytryptamine receptor 3A0101
Histamine H2 receptor0404
Adenosine receptor A10101
Beta-3 adrenergic receptor0101
Adenylate cyclase type 20101
Adenylate cyclase type 40101
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0606
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
5-hydroxytryptamine receptor 1D0101
Gamma-aminobutyric acid receptor subunit alpha-61001
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0404
Histamine H1 receptor0202
5-hydroxytryptamine receptor 7 0202
C-8 sterol isomerase0101
Delta-type opioid receptor0202
Mu-type opioid receptor0202
5-hydroxytryptamine receptor 2C 0202
5-hydroxytryptamine receptor 70202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2A0202
Histamine H1 receptor0404
Mu-type opioid receptor0213
Glutamate receptor ionotropic, NMDA 1 0202
D(3) dopamine receptor0417
Sodium channel protein type 1 subunit alpha0101
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2B0606
5-hydroxytryptamine receptor 2A0101
D(1A) dopamine receptor2103
5-hydroxytryptamine receptor 60202
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
N-acetyltransferase Eis0202
Glutamate receptor ionotropic, NMDA 2A 0202
Glutamate receptor ionotropic, NMDA 2B0202
Glutamate receptor ionotropic, NMDA 2C0202
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
5-hydroxytryptamine receptor 2B0202
Adenylate cyclase type 60101
Adenylate cyclase type 50101
TAR DNA-binding protein 432002
5-hydroxytryptamine receptor 40101
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Sigma intracellular receptor 20101
Sigma non-opioid intracellular receptor 10101
Zinc finger protein 6640101
Glutamate receptor ionotropic, NMDA 2D0202
Vesicular acetylcholine transporter0101
Transporter0202
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
Glutamate receptor ionotropic, NMDA 3B0202
GABA theta subunit1001
D0101
ATPase family AAA domain-containing protein 52002
Sodium channel protein type 2 subunit alpha0101
Transient receptor potential cation channel subfamily V member 40101
Gamma-aminobutyric acid receptor subunit epsilon1001
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0202
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Transient receptor potential cation channel subfamily V member 20101
Sodium channel protein type 10 subunit alpha0101
dopamine D1 receptor2002
bromodomain adjacent to zinc finger domain 2B1001
chromobox protein homolog 13003
Glutamate receptor 10101
Glutamate receptor 30101
Glutamate receptor 40101
Glutamate receptor ionotropic, kainate 10101
Metabotropic glutamate receptor 10011
Metabotropic glutamate receptor 50101
Glutamate receptor ionotropic, kainate 20101
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, kainate 40101
Metabotropic glutamate receptor 10101
Metabotropic glutamate receptor 20112
Metabotropic glutamate receptor 40112
Glutamate receptor ionotropic, kainate 50101
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE1001
Chain B, DIHYDROFOLATE REDUCTASE0011
Chain A, 2-oxoglutarate Oxygenase1001
acid sphingomyelinase1001
ClpP1001
Microtubule-associated protein tau1001
aldehyde dehydrogenase 1 family, member A11001
67.9K protein2002
peroxisome proliferator activated receptor gamma1001
Thymidylate synthase 0101
alpha-galactosidase1001
Thymidylate synthase 0101
cellular tumor antigen p53 isoform a1001
polyunsaturated fatty acid lipoxygenase ALOX121001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
vitamin D3 receptor isoform VDRA2002
transcriptional regulator ERG isoform 32002
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
flap endonuclease 11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA polymerase kappa isoform 11001
M-phase phosphoprotein 81001
muscleblind-like protein 1 isoform 11001
caspase-1 isoform alpha precursor1001
nuclear receptor coactivator 3 isoform a0101
Toll-like receptor 40101
Fatty-acid amide hydrolase 10101
ATP-binding cassette sub-family C member 30102
Dihydrofolate reductase0203
Dihydrofolate reductase0203
Dihydrofolate reductase 0101
Dihydrofolate reductase0101
Dihydrofolate reductase0101
Dihydrofolate reductase0203
Thymidylate synthase0101
Tyrosine-protein kinase ABL10011
Carbonic anhydrase 20011
Thymidylate synthase0202
Integrin beta-31001
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Thymidylate synthase0202
Integrin alpha-IIb1001
High mobility group protein B10011
Dihydrofolate reductase0101
Thymidylate synthase0101
Dihydrofolate reductase0224
Glucose-6-phosphate 1-dehydrogenase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Folate receptor beta0101
Cytochrome P450 11B1, mitochondrial 0101
Folate receptor alpha0101
Dihydrofolate reductase0202
Histidine decarboxylase0101
Trifunctional purine biosynthetic protein adenosine-30101
Cyclin-dependent kinase 20011
Bifunctional purine biosynthesis protein ATIC0202
Multidrug resistance-associated protein 1 0001
Reduced folate transporter0202
Folylpolyglutamate synthase, mitochondrial0103
6-phosphogluconate dehydrogenase, decarboxylating0101
Caspase-71001
Solute carrier organic anion transporter family member 1A30001
Dihydrofolate reductase0101
Pteridine reductase 10101
Folylpolyglutamate synthase, mitochondrial0103
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Bifunctional dihydrofolate reductase-thymidylate synthase0101
Canalicular multispecific organic anion transporter 10102
Trifunctional purine biosynthetic protein adenosine-30101
Solute carrier family 22 member 200101
Dihydrofolate reductase 0101
Solute carrier family 22 member 60101
Dihydrofolate reductase0101
ATP-binding cassette sub-family C member 110001
Proton-coupled folate transporter0101
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1B30001
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Broad substrate specificity ATP-binding cassette transporter ABCG20001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Solute carrier family 22 member 20101
Glycine receptor subunit alpha-10011
Histamine H1 receptor0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
D(2) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
Nuclear receptor subfamily 3 group C member 3 0404
Multidrug and toxin extrusion protein 20101
Histamine H3 receptor0101
PPM1D protein1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
NPC intracellular cholesterol transporter 1 precursor1001
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
Rap guanine nucleotide exchange factor 31001
Transcriptional activator protein LuxR0101
3-oxo-5-alpha-steroid 4-dehydrogenase 20101
Melanocortin receptor 50202
Envelope glycoprotein0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]