Compounds > monascorubrin
Page last updated: 2024-11-12

monascorubrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

monascorubrin: isolated from Monascus species [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID12118084
CHEMBL ID1215464
CHEBI ID156408
MeSH IDM0513473

Synonyms (20)

Synonym
CHEMBL1215464
monascorubrin
CHEBI:156408
(9ar)-9a-methyl-3-octanoyl-6-[(1e)-prop-1-en-1-yl]-2h-furo[3,2-g]isochromene-2,9(9ah)-dione
13283-90-4
monasred
(9ar)-9a-methyl-3-octanoyl-6-[(1e)-prop-1-en-1-yl]-2h-furo[3,2-g][2]benzopyran-2,9(9ah)-dione
prw98qj428 ,
ccris 7225
unii-prw98qj428
2h-furo(3,2-g)(2)benzopyran-2,9(9ah)-dione, 9a-methyl-3-(1-oxooctyl)-6-(1-propenyl)-, (r-(e))-
(9ar)-9a-methyl-3-(1-oxooctyl)-6-(1e)-1-propen-1-yl-2h-furo(3,2-g)(2)benzopyran-2,9(9ah)-dione
2h-furo(3,2-g)(2)benzopyran-2,9(9ah)-dione, 9a-methyl-3-(1-oxooctyl)-6-(1e)-1-propen-1-yl-, (9ar)-
(9ar)-9a-methyl-3-octanoyl-6-[(e)-prop-1-enyl]furo[3,2-g]isochromene-2,9-dione
Q27286726
2h-furo[3,2-g][2]benzopyran-2,9(9ah)-dione, 9a-methyl-3-(1-oxooctyl)-6-(1e)-1-propen-1-yl-, (9ar)-
CS-0144836
HY-N8492
DTXSID101037235
(r,e)-9a-methyl-3-octanoyl-6-(prop-1-en-1-yl)-2h-furo[3,2-g]isochromene-2,9(9ah)-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (6)

RoleDescription
food colouringA food additive that imparts colour to food. In European countries, E-numbers for permitted food colours are from E 100 to E 199, divided into yellows (E 100-109), oranges (E 110-119), reds (E 120-129), blues and violets (E 130-139), greens (E 140-149), browns and blacks (E 150-159), and others (E 160-199).
biological pigmentAn endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light.
fungal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
Hsp90 inhibitorAn EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor that blocks the action of heat shock protein 90.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
azaphiloneAny member of a family of natural products which contains a 6H-isochromene-6,8(7H)-dione or an isoquinoline-6,8(2H,7H)-dione skeleton and its substituted derivatives thereof.
gamma-lactoneA lactone having a five-membered lactone ring.
triketoneA compound that contains three ketone functionalities.
polyketideNatural and synthetic compounds containing alternating carbonyl and methylene groups ('beta-polyketones'), biogenetically derived from repeated condensation of acetyl coenzyme A (via malonyl coenzyme A), and usually the compounds derived from them by further condensations, etc. Considered by many to be synonymous with the less frequently used terms acetogenins and ketides.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID499312Binding affinity to HSP90 after 4 hrs by fluorescence polarization assay2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
AID499308Antiproliferative activity against human A431 cells after 72 hrs2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
AID499311Inhibition of yeast full-length recombinant HSP90 ATPase activity expressed in Escherichia coli strain BL21(DE3) assessed as inorganic phosphate release after 3 hrs2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
AID499310Antiproliferative activity against human IGROV1 cells after 72 hrs2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
AID499307Antiproliferative activity against human NCI-H460 cells after 72 hrs2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
AID499309Antiproliferative activity against human JR8 cells after 72 hrs2010Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16
Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.16 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.46 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.1710alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		1.9510monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
cycloheximide
Cycloheximide: Antibiotic substance isolated from streptomycin-producing strains of Streptomyces griseus. It acts by inhibiting elongation during protein synthesis.. cycloheximide : A dicarboximide that is 4-(2-hydroxyethyl)piperidine-2,6-dione in which one of the hydrogens attached to the carbon bearing the hydroxy group is replaced by a 3,5-dimethyl-2-oxocyclohexyl group. It is an antibiotic produced by the bacterium Streptomyces griseus.		7.0310antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
benzofurans
Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.		2.5520
geldanamycin
[no description available]		2.05101,4-benzoquinones;
ansamycin;
carbamate ester;
organic heterobicyclic compound		antimicrobial agent;
antineoplastic agent;
antiviral agent;
cysteine protease inhibitor;
Hsp90 inhibitor
monorden
monorden: inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II		2.0510cyclic ketone;
enone;
epoxide;
macrolide antibiotic;
monochlorobenzenes;
phenols		antifungal agent;
metabolite;
tyrosine kinase inhibitor
tanespimycin
CP 127374: analog of herbimycin A		2.05101,4-benzoquinones;
ansamycin;
carbamate ester;
organic heterobicyclic compound;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
Hsp90 inhibitor
rubropunctatin
rubropunctatin: an antineoplastic pigment isolated from Monascus; structure in first source		2.5520
monascin
monascin: a pigment isolated from Monascus pilosus fermented rice; has antineoplastic activity; structure in first source. monascin : An organic heterotricyclic compound that is 3a,4,8,9a-tetrahydro-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione that is substituted at positions 3, 6, and 9a by hexanoyl, (1E)-prop-1-en-1-yl and methyl groups, respectively (the 3S,3aR,9aR diastereoisomer). One of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mould rice), it is a potent inhibitor of carcinogenesis measured against chemical- or UV-initiated, phorbol-promoted mouse skin tumours.		2.4920alpha,beta-unsaturated ketone;
gamma-lactone;
organic heterotricyclic compound;
polyketide		antilipemic drug;
antineoplastic agent;
fungal metabolite;
PPARgamma agonist
ankaflavin
ankaflavin: from Monascus-fermented red rice; structure in first source		2.4920
citrinin
Citrinin: Antibiotic and mycotoxin from Aspergillus niveus and Penicillium citrinum.		2.110
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0510
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0510