Page last updated: 2024-09-27

Lichen Nitidus

A chronic inflammatory disease characterized by shiny, flat-topped, usually flesh-colored micropapules no larger than the head of a pin. Lesions are localized in the early stages, found chiefly on the lower abdomen, penis, and inner surface of the thighs. Distribution may become generalized as the disease progresses.

Synonyms(1)

Synonym
Lichen Nitidus

Research Excerpts

Overview

ExcerptReference
"Lichen nitidus is an uncommon dermatosis of unknown etiology."( Bieber, T; Bräuninger, W; Proelss, J; Scheler, M; Wenzel, J, 2007)
"Lichen nitidus is an unusual condition with chronic evolution."( Benchikhi, H; Bouras, M; Ouakkadi, A; Zamiati, S, 2013)
"Actinic lichen nitidus is rare."( Benchikhi, H; Bouras, M; Ouakkadi, A; Zamiati, S, 2013)

Research

Studies (26)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (3.85)23.3326
1990's8 (30.77)12.5806
2000's8 (30.77)18.1394
2010's8 (30.77)28.8240
2020's1 (3.85)9.53
DrugIndicatedRelationship StrengthStudiesTrials
dinitrochlorobenzene0low20
salicylic acid0low10
dalteparin0low10
propylene glycol0low10
urea0low10
astemizole0low30
cetirizine0low10
dapsone0low10
hydroxychloroquine0low10
isoniazid0low10
prednisolone0low20
ficusin0low10
potassium dichromate0low10
levamisole0low10
ribavirin0low10
itraconazole0low10
tacrolimus0low30
bromochloroacetic acid0low10
acitretin0low20
hoe 7770low10
cyclosporine0low10

Protein Targets (464)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, JmjC domain-containing histone demethylation protein 3A2002
Luciferase5005
USP1 protein, partial8008
TDP1 protein140014
Microtubule-associated protein tau4004
AR protein180018
aldehyde dehydrogenase 1 family, member A18008
glucocorticoid receptor [Homo sapiens]130013
estrogen nuclear receptor alpha200020
peroxisome proliferator activated receptor gamma110011
euchromatic histone-lysine N-methyltransferase 2100010
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a120012
vitamin D3 receptor isoform VDRA3003
thyroid hormone receptor beta isoform 2130013
flap endonuclease 12002
serine/threonine-protein kinase PLK13003
eyes absent homolog 2 isoform a1001
DNA polymerase eta isoform 13003
geminin120012
peripheral myelin protein 226006
survival motor neuron protein isoform d6006
histone acetyltransferase KAT2A isoform 14004
ATP-binding cassette sub-family C member 30909
Multidrug resistance-associated protein 40909
Bile salt export pump0404
Bile salt export pump011011
Rap guanine nucleotide exchange factor 35005
Cellular tumor antigen p53150015
Rap guanine nucleotide exchange factor 42002
Chain A, Beta-lactamase5005
acetylcholinesterase2002
glp-1 receptor, partial3003
phosphopantetheinyl transferase3003
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma140014
SMAD family member 24004
Fumarate hydratase2002
SMAD family member 34004
GLI family zinc finger 3120012
Smad33003
caspase 7, apoptosis-related cysteine protease4004
estrogen receptor 2 (ER beta)6006
nuclear receptor subfamily 1, group I, member 3130013
progesterone receptor5005
cytochrome P450 family 3 subfamily A polypeptide 49009
nonstructural protein 12002
retinoic acid nuclear receptor alpha variant 1130013
retinoid X nuclear receptor alpha100010
estrogen-related nuclear receptor alpha140014
farnesoid X nuclear receptor8008
pregnane X nuclear receptor110011
cytochrome P450 2D63003
polyprotein2002
67.9K protein6006
glucocerebrosidase1001
bromodomain adjacent to zinc finger domain 2B4004
peroxisome proliferator-activated receptor delta9009
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
caspase-34004
IDH15005
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
aryl hydrocarbon receptor7007
thyroid stimulating hormone receptor6006
activating transcription factor 67007
thyrotropin-releasing hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x5005
Caspase-73003
Spike glycoprotein0033
Replicase polyprotein 1ab0033
cytochrome P450 2D6 isoform 13003
lysosomal alpha-glucosidase preproprotein2002
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
nuclear factor erythroid 2-related factor 2 isoform 28008
potassium voltage-gated channel subfamily H member 2 isoform d4004
caspase-33003
heat shock protein beta-16006
huntingtin isoform 21001
ubiquitin-conjugating enzyme E2 N0101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 1130013
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 14004
cytochrome P450 3A4 isoform 17007
lamin isoform A-delta108008
Gamma-aminobutyric acid receptor subunit pi7007
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20033
Voltage-dependent L-type calcium channel subunit alpha-1F0202
5-hydroxytryptamine receptor 40202
Polycomb protein EED0202
Voltage-dependent calcium channel gamma-2 subunit9009
Epidermal growth factor receptor0101
Interferon beta8008
HLA class I histocompatibility antigen, A alpha chain 0011
Receptor tyrosine-protein kinase erbB-20101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Procathepsin L0033
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M40303
ATP-dependent translocase ABCB10101
Beta-1 adrenergic receptor0202
Cytochrome P450 3A40415
Muscarinic acetylcholine receptor M50303
Alpha-2A adrenergic receptor0303
Neuronal acetylcholine receptor subunit alpha-42002
Replicase polyprotein 1a0134
Replicase polyprotein 1ab0033
Replicase polyprotein 1ab0134
Adenosine receptor A30707
Replicase polyprotein 1ab0134
Muscarinic acetylcholine receptor M10303
Neuronal acetylcholine receptor subunit beta-22002
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit beta-17007
Alpha-1B adrenergic receptor0606
Alpha-2B adrenergic receptor0505
Gamma-aminobutyric acid receptor subunit delta7007
Gamma-aminobutyric acid receptor subunit gamma-27007
Alpha-2C adrenergic receptor0303
5-hydroxytryptamine receptor 1A0303
Glutamate receptor 29009
Gamma-aminobutyric acid receptor subunit alpha-57007
Gamma-aminobutyric acid receptor subunit alpha-37007
Muscarinic acetylcholine receptor M30303
ATP-dependent translocase ABCB10101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Glycine receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit gamma-17007
Gamma-aminobutyric acid receptor subunit alpha-27007
Sodium-dependent noradrenaline transporter 0202
Histamine H2 receptor0202
Alpha-1D adrenergic receptor0404
Substance-P receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-47007
Gamma-aminobutyric acid receptor subunit gamma-37007
5-hydroxytryptamine receptor 1B0202
Gamma-aminobutyric acid receptor subunit alpha-67007
Somatostatin receptor type 20101
Somatostatin receptor type 40101
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
Somatostatin receptor type 30101
Melanocortin receptor 50202
Somatostatin receptor type 50101
Histamine H1 receptor0303
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0606
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0606
Histamine H2 receptor3003
5-hydroxytryptamine receptor 60303
Cytochrome P450 2J20102
Spike glycoprotein4037
Gamma-aminobutyric acid receptor subunit alpha-17007
Gamma-aminobutyric acid receptor subunit beta-37007
Gamma-aminobutyric acid receptor subunit beta-27007
Disintegrin and metalloproteinase domain-containing protein 171001
Inositol monophosphatase 11001
Voltage-dependent L-type calcium channel subunit alpha-1D 0202
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20415
Voltage-dependent L-type calcium channel subunit alpha-1S0202
Voltage-dependent L-type calcium channel subunit alpha-1C0202
Sigma intracellular receptor 20202
GABA theta subunit7007
Canalicular multispecific organic anion transporter 10808
Multidrug and toxin extrusion protein 10202
ATPase family AAA domain-containing protein 57007
Ataxin-28008
Sigma non-opioid intracellular receptor 10303
Angiotensin-converting enzyme 2 0033
Gamma-aminobutyric acid receptor subunit epsilon7007
Histamine H4 receptor0202
Heparanase0011
Nuclear receptor ROR-gamma5117
atrial natriuretic peptide receptor 2 precursor1001
Angiopoietin-1 receptor0011
ATP-dependent phosphofructokinase3003
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE4004
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 0101
interleukin 82002
thyroid stimulating hormone receptor3003
G5005
cytochrome P450 2C9 precursor2002
muscleblind-like protein 1 isoform 11001
HLA class I histocompatibility antigen, B alpha chain 5005
Myeloperoxidase0202
Dihydrofolate reductase0101
Inositol hexakisphosphate kinase 15005
cytochrome P450 2C9, partial5005
thioredoxin reductase7007
ATAD5 protein, partial3003
thioredoxin glutathione reductase2002
apical membrane antigen 1, AMA12002
thyroid hormone receptor beta isoform a5005
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA polymerase iota isoform a (long)5005
Vpr2002
Glutathione S-transferase omega-10101
TAR DNA-binding protein 431001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Chain A, 2-oxoglutarate Oxygenase5005
chromobox protein homolog 18008
lethal factor (plasmid)3003
Acetylcholinesterase0101
Cytochrome P450 2A60202
Nuclear factor NF-kappa-B p105 subunit0101
Amine oxidase [flavin-containing] A0101
Acetylcholinesterase0202
Amine oxidase [flavin-containing] B0101
Beta-secretase 10101
Genome polyprotein 0101
EWS/FLI fusion protein5005
Cyclic GMP-AMP synthase0101
Toll-like receptor 90101
Toll-like receptor 70101
GLS protein2002
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20203
Cytochrome P450 1A20112
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190213
Endonuclease III-like protein 10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
Chain A, Ferritin light chain3003
Chain A, Cruzipain2002
regulator of G-protein signaling 42002
Parkin2002
Bloom syndrome protein isoform 13003
peripheral myelin protein 22 isoform 12002
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
Ornithine decarboxylase0002
Retinoic acid receptor alpha0224
Retinoic acid receptor gamma0224
Retinoic acid receptor beta0224
Cellular retinoic acid-binding protein 20022
Mitogen-activated protein kinase 10202
Retinoic acid receptor RXR-alpha0224
Retinoic acid receptor RXR-beta0224
Retinoic acid receptor RXR-gamma0224
Cellular retinoic acid-binding protein 10203
Cellular retinoic acid-binding protein 10022
Mitogen-activated protein kinase 140101
Olfactory receptor 51E20112
GALC protein2002
Cytochrome P450 1440011
Steroid C26-monooxygenase0011
Steroid C26-monooxygenase0011
dopamine D1 receptor1001
atrial natriuretic peptide receptor 1 precursor1001
Alkaline phosphatase, tissue-nonspecific isozyme0202
Alkaline phosphatase, placental type0101
Alkaline phosphatase, tissue-nonspecific isozyme 0202
Intestinal-type alkaline phosphatase0101
Intestinal-type alkaline phosphatase0101
5'-nucleotidase0101
Phospholipase A-2-activating protein0101
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
5-hydroxytryptamine receptor 2A0011
PAX80001
PPM1D protein2002
alpha-galactosidase2002
nuclear receptor subfamily 1, group I, member 23003
NPC intracellular cholesterol transporter 1 precursor1001
nuclear receptor subfamily 0 group B member 10101
ras-related protein Rab-9A1001
steroidogenic factor 10101
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Regulatory protein E20011
Regulatory protein E20011
Regulatory protein E20011
Glucocorticoid receptor0319
Tubulin beta-4A chain0113
Prostaglandin G/H synthase 10101
Tubulin beta chain0113
Tubulin alpha-3C chain0113
Cytochrome P450 2C9 0213
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Prostaglandin G/H synthase 20101
Tubulin beta-3 chain0113
Tubulin beta-2A chain0113
Tubulin beta-8 chain0113
Calcium-activated potassium channel subunit alpha-10101
Tubulin beta-2B chain0101
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
pregnane X receptor2002
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Prostaglandin G/H synthase 20202
Nociceptin receptor0011
Estrogen receptor beta0202
transcriptional regulator ERG isoform 31001
NS5 0011
Thrombopoietin1001
arylsulfatase A1001
glycogen synthase kinase-3 beta isoform 10011
muscarinic acetylcholine receptor M11001
Polymerase basic protein 20011
RNA-directed RNA polymerase catalytic subunit0011
Polymerase acidic protein0022
Adenosylhomocysteinase0002
Adenosine receptor A2a0101
Adenosine receptor A10101
Adenosine receptor A10101
Genome polyprotein0011
chaperonin-containing TCP-1 beta subunit homolog1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Albumin0101
Carbonic anhydrase 30101
Stromelysin-10011
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60101
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80101
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
DNA polymerase kappa isoform 13003
Nuclear receptor subfamily 1 group I member 20022
UDP-glucuronosyltransferase 2B70001
Cytochrome P450 3A50101
UDP-glucuronosyltransferase 1A40001
Serine/threonine-protein kinase mTOR0101
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Peptidyl-prolyl cis-trans isomerase FKBP50101
Splicing factor 3B subunit 30101
Broad substrate specificity ATP-binding cassette transporter ABCG20101
Solute carrier organic anion transporter family member 1B10102
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0246
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Chain A, Nuclear Receptor ROR-beta0101
M-phase phosphoprotein 81001
Amyloid-beta precursor protein0101
Ornithine decarboxylase0001
60 kDa chaperonin0101
Retinoic acid receptor alpha0227
Cytochrome P450 2D60011
60 kDa heat shock protein, mitochondrial0101
Retinoic acid receptor beta0227
Retinoic acid receptor gamma 0227
Alpha-1A adrenergic receptor0101
Alpha-1D adrenergic receptor0101
Retinoic acid receptor RXR-beta0224
Indoleamine 2,3-dioxygenase 10101
Nuclear receptor ROR-alpha0101
Alpha-synuclein0101
Retinoic acid receptor RXR-gamma0224
10 kDa heat shock protein, mitochondrial0101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10213
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Indoleamine 2,3-dioxygenase 20101
Nuclear receptor ROR-beta0101
Urease subunit alpha0101
Urease subunit beta0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]