3--4--7-trihydroxyflavone and baicalein

Plant polyphenols have been highlighted not only as chemopreventive, but also as potential anticancer substances. Flavones are a subclass of natural flavonoids reported to have an antioxidant and anticancer activity. The aim of our study was to evaluate antioxidant and anticancer activity of seventeen trihydroxyflavone derivatives, including apigenin (API) and baicalein (BCL). Also, we wanted to find out if there is a correlation between those two effects. Cell growth inhibition testing was carried out using MTT assay in three different human cancer cell lines: lung (A549), breast (MCF-7) and brain epithelial (U87). Antioxidant activity was determined by the DPPH radical scavenging method. Thirteen trihydroxyflavones possessed anticancer activity against at least one tested cancer cell line. They were more active against the MCF-7 cell line, and the lowest activity was determined against the U87 cell line. The majority of compounds inhibited cancer cell growth at EC. Trihydroxyflavones demonstrated anticancer activity. Further and more detailed studies should to be carried out to estimate the structure-activity relationship of these compounds.

Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Antioxidants; Apigenin; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Flavanones; Flavonoids; Humans; Inhibitory Concentration 50; MCF-7 Cells; Picrates; Structure-Activity Relationship