negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric

Definition

Target type: biologicalprocess

Any process that stops, prevents or reduces the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:rph, GOC:TermGenie, PMID:26373281]

Negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric, refers to the process of inhibiting or reducing the stability of the protein complexes that hold sister chromatids together at their telomeres during mitosis. Telomeres are specialized structures at the ends of chromosomes that protect them from degradation and fusion. During DNA replication, the telomeres are replicated by a specialized enzyme called telomerase. However, telomerase is not always perfectly efficient, and telomeres can become shorter with each cell division. This shortening can lead to chromosome instability and cell death.

To prevent these problems, cells have evolved mechanisms to maintain telomere length and protect the ends of chromosomes. One important mechanism is the maintenance of mitotic sister chromatid cohesion at telomeres. Sister chromatid cohesion is the process of holding together the two identical copies of a chromosome that are produced during DNA replication. This cohesion is essential for proper chromosome segregation during mitosis, ensuring that each daughter cell receives a complete set of chromosomes.

The protein complexes that mediate sister chromatid cohesion at telomeres are called cohesin complexes. Cohesin complexes are loaded onto chromosomes during DNA replication and remain associated with the chromosomes throughout mitosis. During mitosis, the cohesin complexes are progressively removed from chromosomes, allowing the sister chromatids to separate and migrate to opposite poles of the cell. This process is tightly regulated to ensure that the chromosomes are properly segregated and that each daughter cell receives a complete set of chromosomes.

Negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric, involves the inhibition of cohesin complex function at telomeres. This can be achieved through a variety of mechanisms, such as the recruitment of proteins that can directly interact with cohesin complexes and disrupt their activity, or the activation of signaling pathways that lead to the phosphorylation or ubiquitination of cohesin complex components.

The downregulation of cohesin complex function at telomeres can have several consequences. First, it can lead to premature separation of sister chromatids, resulting in chromosome instability and aneuploidy. Second, it can affect the proper replication of telomeres, leading to telomere shortening and further instability. Finally, it can contribute to the activation of DNA damage response pathways, which can ultimately lead to cell cycle arrest or apoptosis.

In summary, negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric, is a complex process that plays a critical role in regulating chromosome segregation and maintaining genomic stability. It involves the downregulation of cohesin complex function at telomeres, which can be achieved through a variety of mechanisms. Dysregulation of this process can have severe consequences for cell function and can contribute to the development of cancer and other diseases.'
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Proteins (1)

Compounds (34)