positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

Definition

Target type: biologicalprocess

Any process that activates or increases the frequency, rate or extent of adenylate cyclase-inhibiting dopamine receptor signaling pathway. [GO_REF:0000058, GOC:kmv, GOC:TermGenie, PMID:26554819]

The positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway is a complex process involving a series of molecular events that ultimately lead to an increase in the activity of the adenylate cyclase-inhibiting dopamine receptor. This receptor, also known as the D2 dopamine receptor, is a G protein-coupled receptor (GPCR) that is primarily responsible for mediating the inhibitory effects of dopamine in the brain.

The pathway begins with the binding of dopamine to the D2 receptor. This interaction triggers a conformational change in the receptor, which then activates a heterotrimeric G protein. The G protein consists of three subunits: alpha (α), beta (β), and gamma (γ). Upon activation, the α subunit dissociates from the βγ subunits and binds to adenylate cyclase, an enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP).

In this pathway, however, the D2 receptor is an inhibitory receptor. Therefore, activation of the G protein leads to the inhibition of adenylate cyclase, resulting in a decrease in cAMP production. This reduction in cAMP levels ultimately leads to the inhibition of downstream signaling pathways, such as the protein kinase A (PKA) pathway.

The positive regulation of this pathway involves processes that enhance the activity of the D2 receptor or its associated signaling molecules. These processes can include:

* **Increased dopamine synthesis and release:** A higher concentration of dopamine in the synapse will lead to greater activation of the D2 receptor.
* **Increased receptor expression:** An increase in the number of D2 receptors on the cell surface will enhance the overall signaling response.
* **Phosphorylation of the receptor:** Phosphorylation of the D2 receptor by specific kinases can modulate its activity and enhance signaling.
* **Activation of downstream signaling molecules:** Factors that stimulate the activity of the G protein or other components of the signaling pathway can indirectly enhance the inhibitory effects of the D2 receptor.

The positive regulation of this pathway is crucial for maintaining proper dopaminergic signaling in the brain. It plays a role in various neurological processes, including motor control, reward, and motivation. Dysregulation of this pathway has been implicated in several neurological disorders, including Parkinson's disease, schizophrenia, and addiction.'
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Proteins (1)

Compounds (12)