Golgi ribbon formation

Definition

Target type: biologicalprocess

The formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae. [GOC:ascb_2009, GOC:dph, GOC:tb]

The formation of Golgi ribbons, which are interconnected stacks of Golgi apparatus, is a complex process that involves multiple steps and factors. It is essential for efficient protein sorting and modification within eukaryotic cells.

**1. Initial Clustering and Tethering:**
- The Golgi apparatus exists as individual stacks called cisternae.
- These cisternae initially cluster together through a process called "clustering."
- This clustering is mediated by tethering proteins, such as GRASP55 and GRASP65.
- Tethering proteins act as bridges between Golgi cisternae, bringing them closer together.

**2. Microtubule-Mediated Transport:**
- Microtubules play a crucial role in Golgi ribbon formation by transporting Golgi stacks.
- Microtubule motor proteins, such as dynein and kinesin, attach to Golgi cisternae and move them along microtubule tracks.
- This transport helps bring the Golgi stacks closer to each other.

**3. Fusion and Interconnection:**
- Once the Golgi stacks are sufficiently close, they begin to fuse with each other.
- Fusion is facilitated by specific fusion proteins, such as SNARE proteins.
- The fusion process creates connections between the Golgi stacks, forming a continuous ribbon.

**4. Structural Organization:**
- Once a ribbon is formed, the Golgi cisternae remain connected through a network of protein bridges and tethers.
- This network provides structural support and ensures the proper organization of the Golgi ribbon.

**5. Regulation:**
- Golgi ribbon formation is regulated by various factors, including cell type, cell cycle stage, and external signals.
- For example, the activation of specific signaling pathways can trigger changes in Golgi ribbon morphology.

**6. Function:**
- The Golgi ribbon provides an efficient platform for protein processing and sorting.
- The interconnected network of cisternae allows for sequential modifications and transport of proteins through the Golgi apparatus.
- This structure also facilitates the movement of vesicles carrying processed proteins to other cellular compartments.'
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Proteins (1)

Compounds (12)