furamidine has been researched along with pafuramidine in 23 studies
| Studies (furamidine) | Trials (furamidine) | Recent Studies (post-2010) (furamidine) | Studies (pafuramidine) | Trials (pafuramidine) | Recent Studies (post-2010) (pafuramidine) |
|---|---|---|---|---|---|
| 108 | 1 | 32 | 42 | 4 | 11 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 19 (82.61) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boykin, DW; Brun, R; Easterbrook, JD; Ismail, MA; Tanious, FA; Wilson, WD | 1 |
| Boykin, DW; Brun, R; Ismail, MA; Tanious, FA; Wenzler, T; Wilson, WD | 1 |
| Anbazhagan, M; Ansede, JH; Boykin, DW; Brun, R; Easterbrook, JD; Hall, JE | 1 |
| Arafa, RK; Boykin, DW; Bridges, A; Brun, R; Generaux, C; Hall, JE; Ismail, MA; Miao, Y; Wenzler, T; Wilson, WD | 1 |
| Boykin, DW; Hall, JE; Jones, SK; Rahmathullah, SM; Tidwell, RR | 1 |
| Arafa, RK; Boykin, DW; Brun, R; Ismail, MA; Tanious, FA; Wenzler, T; Wilson, WD | 1 |
| Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T | 1 |
| Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD | 1 |
| Bondada, L; Boykin, DW; Brun, R; Hu, L; Munde, M; Patel, A; Wang, MZ; Wenzler, T; Wilson, WD; Yang, S | 1 |
| Andrews, KT; Bouchut, A; Chua, MJ; Erdmann, F; Khalife, J; Pierrot, C; Robaa, D; Sauer, B; Schmidt, M; Sippl, W; Skinner-Adams, TS | 1 |
| Anbazhagan, M; Boykin, DW; Hall, JE; Stephens, CE; Thakker, DR; Tidwell, RR; Voyksner, RD; Zhou, L | 1 |
| Boykin, DW; Hall, JE; Lee, K; Thakker, DR; Tidwell, RR; Zhou, L | 1 |
| Boykin, DW; Brock, KV; Dykstra, CC; Givens, MD; Goker, H; Kumar, A; Stephens, CE; Stringfellow, DA | 1 |
| Yeates, C | 1 |
| Bagnell, CR; Brock, JL; Hall, JE; Sturk, LM; Tidwell, RR | 1 |
| Anbazhagan, M; Boykin, DW; Bridges, AS; Hall, JE; Kurian, JR; Saulter, JY; Stephens, CE; Tidwell, RR; Trepanier, LA | 1 |
| Werbovetz, K | 1 |
| Boykin, DW; Cybulski, ZR; Fitzpatrick, K; Henderson, SJ; Houchen, TL; John, BA; McBurney, A; Midgley, I; Taylor, LM; Trendler, KL; Wright, SJ | 1 |
| Bridges, AS; Hall, JE; Kornbluth, S; Paine, MF; Tidwell, RR; Wang, MZ; Wu, JQ; Zeldin, DC | 1 |
| Meshnick, SR; Purfield, AE; Tidwell, RR | 1 |
| Brun, R; Kagira, JM; Karanja, SM; Mdachi, RE; Ngotho, JM; Thuita, JK; Tidwell, R; Wenzler, T | 1 |
| Bakshi, RP; Hendrix, CW; Kumar, N; Nyunt, MM; Shapiro, TA | 1 |
| Generaux, CN; Goldsmith, RB; Gray, DR; Reisner, HM; Tidwell, RR; Yan, Z | 1 |
2 review(s) available for furamidine and pafuramidine
| Article | Year |
|---|---|
DB-289 Immtech International.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Antitubercular Agents; Benzamidines; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Prodrugs; Structure-Activity Relationship; Trypanocidal Agents | 2003 |
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Malaria, Falciparum; Pentamidine; Plasmodium falciparum; Prodrugs; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma cruzi; Trypanosomiasis, African | 2006 |
1 trial(s) available for furamidine and pafuramidine
| Article | Year |
|---|---|
Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites.
Topics: Adult; Animals; Anopheles; Antimalarials; Area Under Curve; Benzamidines; Cohort Studies; Double-Blind Method; Drug Administration Schedule; Erythrocytes; Female; Half-Life; Humans; Insect Vectors; Malaria, Falciparum; Male; Middle Aged; Molecular Structure; Plasmodium falciparum; Young Adult | 2009 |
20 other study(ies) available for furamidine and pafuramidine
| Article | Year |
|---|---|
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Aza Compounds; Benzamidines; Mice; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2003 |
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Imidazoles; Mice; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense | 2004 |
O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection.
Topics: Administration, Oral; Animals; Benzamidines; Biological Transport; Caco-2 Cells; Disease Models, Animal; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Permeability; Prodrugs; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2004 |
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Biotransformation; Cations; DNA; Drug Stability; In Vitro Techniques; Liver; Mice; Microsomes; Molecular Structure; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma brucei rhodesiense | 2006 |
Carbamate prodrugs of N-alkylfuramidines.
Topics: Animals; Benzamidines; Carbamates; Cysts; Disease Models, Animal; Furans; Lung; Pneumocystis carinii; Pneumonia, Pneumocystis; Prodrugs; Rats | 2008 |
Synthesis and antiprotozoal activity of novel bis-benzamidino imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Combinatorial Chemistry Techniques; Disease Models, Animal; Inhibitory Concentration 50; Mice; Molecular Structure; Plasmodium falciparum; Prodrugs; Pyridines; Trypanosoma brucei rhodesiense | 2008 |
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289.
Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2009 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Protozoan; Drug Stability; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Animal; Mice; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Poly dA-dT; Prodrugs; Pyrazines; Rats; Structure-Activity Relationship; Transition Temperature; Trypanosoma brucei rhodesiense; Trypanosomiasis, African | 2013 |
Synthesis, biological characterisation and structure activity relationships of aromatic bisamidines active against Plasmodium falciparum.
Topics: Antimalarials; Caco-2 Cells; Chemistry Techniques, Synthetic; Drug Design; Furans; HEK293 Cells; Humans; Plasmodium falciparum; Structure-Activity Relationship | 2017 |
Characterizing the fragmentation of 2,5-bis (4-amidinophenyl)furan-bis-O-methylamidoxime and selected metabolites using ion trap mass spectrometry.
Topics: Benzamidines; Molecular Structure; Prodrugs; Spectrometry, Mass, Electrospray Ionization; Trypanocidal Agents | 2002 |
Enhanced permeability of the antimicrobial agent 2,5-bis(4-amidinophenyl)furan across Caco-2 cell monolayers via its methylamidoidme prodrug.
Topics: Anti-Infective Agents; Benzamidines; Caco-2 Cells; Humans; Permeability; Prodrugs | 2002 |
Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.
Topics: Animals; Antiviral Agents; Benzamidines; Cations; Cattle; Diarrhea Viruses, Bovine Viral; Furans; Guanidines; Imidazoles; RNA, Viral; Structure-Activity Relationship | 2003 |
Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
Topics: Administration, Oral; Animals; Benzamidines; Blood-Brain Barrier; Brain; Injections, Intravenous; Male; Mice; Microscopy, Fluorescence; Prodrugs; Tissue Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2004 |
Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase.
Topics: Benzamidines; Cytochrome-B(5) Reductase; Cytochromes b5; Cytosol; Humans; Microsomes, Liver | 2005 |
Pharmacokinetics and metabolism of the prodrug DB289 (2,5-bis[4-(N-methoxyamidino)phenyl]furan monomaleate) in rat and monkey and its conversion to the antiprotozoal/antifungal drug DB75 (2,5-bis(4-guanylphenyl)furan dihydrochloride).
Topics: Animals; Antifungal Agents; Antiprotozoal Agents; Benzamidines; Bile; Biotransformation; Blood Proteins; Feces; Female; Humans; Macaca fascicularis; Male; Mice; Milk; Pregnancy; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2007 |
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Topics: Amidines; Antibodies; Antiparasitic Agents; Arachidonic Acid; Benzamidines; Benzoflavones; Butyrophenones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Intestinal Mucosa; Intestines; Kinetics; Methylation; Microsomes; Oxygenases; Piperidines; Prodrugs; Recombinant Proteins; Stereoisomerism | 2007 |
Interactions of DB75, a novel antimalarial agent, with other antimalarial drugs in vitro.
Topics: Animals; Antimalarials; Atovaquone; Benzamidines; Chloroquine; Drug Interactions; Parasitic Sensitivity Tests; Plasmodium falciparum | 2008 |
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Benzamidines; Female; Humans; Mice; Molecular Structure; Pentamidine; Prodrugs; Trypanosoma brucei gambiense; Trypanosomiasis, African | 2008 |
Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Benzamidines; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Hepatocytes; Humans; Immunoglobulin G; Male; Mice; Mice, Inbred BALB C; Pentamidine; Prodrugs; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tandem Mass Spectrometry; Trypanocidal Agents; Trypanosomiasis, African | 2010 |