GATOR1 complex binding

Definition

Target type: molecularfunction

Binding to a GATOR1 complex. [PMID:28199306]

The GATOR1 complex is a multi-protein complex that acts as a key regulator of the mTORC1 pathway, a central signaling hub controlling cell growth and metabolism. GATOR1 binding is essential for the proper function of this complex, and disruption of this interaction can have significant consequences for cellular homeostasis. The GATOR1 complex itself consists of four subunits: DEPDC5, NPRL2, NPRL3, and SEH1L. It is known to bind to the Rheb-Rag GTPase complex, which is a crucial upstream activator of mTORC1. This binding event is critical for the regulation of mTORC1 activity. In the absence of growth factor signals, the GATOR1 complex is in an active state and inhibits Rheb-Rag GTPase complex activation of mTORC1. This suppression is achieved through GATOR1's ability to promote the GTPase activity of the Rag GTPases, converting them to their inactive GDP-bound state. In contrast, under nutrient-rich conditions or upon growth factor stimulation, the GATOR1 complex is inactivated, allowing the Rheb-Rag GTPase complex to activate mTORC1. This activation is crucial for triggering downstream pathways involved in protein synthesis, nutrient uptake, and cell growth. Therefore, GATOR1 binding is essential for the precise regulation of mTORC1 signaling and the maintenance of cellular balance.'
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Proteins (1)

Compounds (19)