phenamidine profile

Phenamidine is a diamidine derivative that has been studied for its potential as an antiparasitic drug. It is synthesized through a multi-step process involving the condensation of 4-aminobenzamidine with an appropriate aromatic aldehyde. Phenamidine exhibits antiprotozoal activity, particularly against trypanosomes and leishmania. It acts by inhibiting DNA synthesis in these organisms. The compound has been shown to be effective in treating African trypanosomiasis, a deadly disease caused by parasitic protozoa. Research on phenamidine is ongoing, with efforts focused on improving its pharmacokinetic properties and developing new derivatives with enhanced efficacy and reduced toxicity. It holds promise as a potential treatment for other parasitic diseases, including Chagas disease and visceral leishmaniasis.'

phenamidine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	64948
CHEMBL ID	588339
SCHEMBL ID	483100
MeSH ID	M0042120

Synonym
c-[4-(4-diaminomethyl-phenoxy)-phenyl]-methanediamine
4-(4-carbamimidoylphenoxy)benzamidine
phenamidine
101-62-2
4,4'-dibenzamidine oxide
4-(4-carbamimidoylphenoxy)benzenecarboximidamide
CHEMBL588339
einecs 202-960-8
382086v7ib ,
unii-382086v7ib
4,4'-oxydibenzamidine
phenamidine [mi]
benzamidine, 4,4'-oxydi-
4,4'-oxybisbenzenecarboximidamide
SCHEMBL483100
DTXSID10143619
4,4/'-dibenzamidine oxide
Q2085485

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID1506644	Inhibition of PRMT1 (unknown origin) assessed as residual enzyme activity by measuring methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 100 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 15 mins by	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID1506643	Inhibition of PRMT1 (unknown origin) assessed as residual enzyme activity by measuring methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 10 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 15 mins by s	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID1506645	Inhibition of PRMT5 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 10 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 45 mins by scintillation proximity as	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
AID1506646	Inhibition of PRMT5 (unknown origin) assessed as reduction in methyl transfer from [3H]-SAM to biotinylated histone H4 peptide H4-20-Biotin at 100 uM pre-incubated for 3 mins before [3H]-SAM addition and measured after 45 mins by scintillation proximity a	2017	MedChemComm, Feb-01, Volume: 8, Issue:2	Discovery of Decamidine as a New and Potent PRMT1 Inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	6 (60.00)	18.7374
1990's	2 (20.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	1 (10.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (10.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
quinacrine Quinacrine: An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.. quinacrine : A member of the class of acridines that is acridine substituted by a chloro group at position 6, a methoxy group at position 2 and a [5-(diethylamino)pentan-2-yl]nitrilo group at position 9.	6.92	1	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor
putrescine [no description available]	1.99	1	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
diminazene Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.	2.88	4	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug
dapi DAPI: RN given refers to parent cpd.	1.99	1	indoles	fluorochrome
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2.7	3	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
dibrompropamidine [no description available]	2	1	aromatic ether
propamidine propamidine: structure given in first source. propamidine : A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.	2.7	3	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
hexamidine hexamidine : A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.	2.15	1	aromatic ether; guanidines; polyether	antimicrobial agent; antiseptic drug
furamidine furamidine: RN given refers to parent cpd; WR 199385 refers to di-HCl; pafuramidine is a prodrug of this	2.15	1
butamidine butamidine: RN refers to HCl; structure in first source	2.15	1
diminazene aceturate diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.	2.67	3	N-acetylglycinate salt	antiparasitic agent; trypanocidal drug
hydroxystilbamidine hydroxystilbamidine: minor descriptor (63-86); on-line & INDEX MEDICUS search STILBAMIDINES (66-86); RN given refers to parent cpd	1.99	1
stilbamidine stilbamidine: RN given refers to parent cpd	2.7	3
amicarbalide diisethionate amicarbalide diisethionate: structure	2.4	2
trypan blue Trypan Blue: A diazo-naphthalene sulfonate that is widely used as a stain.. trypan blue : An organosulfonate salt that is the tetrasodium salt of 3,3'-[(3,3'-dimethylbiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-amino-4-hydroxynaphthalene-2,7-disulfonic acid).	1.95	1

Condition	Relationship Strength	Studies
Babesia Infection [description not available]	2.85	4
Canine Diseases [description not available]	2.64	3
Acariasis [description not available]	1.93	1
Infections, Tick-Borne [description not available]	1.92	1
Anaplasma Infection [description not available]	1.92	1
Pyrexia [description not available]	1.92	1
Corridor Disease [description not available]	1.92	1
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	6.92	1
Acquired Immune Deficiency Syndrome [description not available]	1.98	1
Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.	1.98	1
Electrolytes Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	2	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1
Coagulation, Disseminated Intravascular [description not available]	1.95	1
Acute Disease Disease having a short and relatively severe course.	1.95	1
Disseminated Intravascular Coagulation A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.	1.95	1

phenamidine

Description

Cross-References

Synonyms (18)

Bioassays (4)

Research

Studies (10)

Market Indicators

Research Demand Index: 33.08

Study Types

phenamidine

Description

Cross-References

Synonyms (18)

Bioassays (4)

Research

Studies (10)

Market Indicators

Research Demand Index: 33.08

Study Types

Related Drugs (15)

Related Conditions (15)