Page last updated: 2024-10-24
3'-tyrosyl-DNA phosphodiesterase activity
Definition
Target type: molecularfunction
Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. [PMID:10521354, PMID:16751265]
3'-Tyrosyl-DNA phosphodiesterase activity is a critical molecular function involved in DNA repair mechanisms, specifically in the removal of 3'-tyrosine adducts from DNA. These adducts are commonly formed as a result of oxidative damage or exposure to genotoxic agents. The enzyme catalyzes the hydrolysis of the phosphodiester bond between the 3'-terminal deoxyribose of DNA and the tyrosine residue, effectively releasing the tyrosine adduct and restoring the integrity of the DNA strand. This activity is essential for maintaining genomic stability and preventing mutations that can lead to various diseases.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Tyrosyl-DNA phosphodiesterase 1 | A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NUW8] | Homo sapiens (human) |
Compounds (26)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tyrphostin 25 | benzenetriol | ||
| aurintricarboxylic acid | aurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'. Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues. | monohydroxybenzoic acid; quinomethanes; tricarboxylic acid | fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist |
| framycetin | framycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B. Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed) | aminoglycoside | allergen; antibacterial drug; Escherichia coli metabolite |
| camptothecin | NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source | delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol | antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite |
| lividomycin | lividomycins | metabolite | |
| n,n'-dibenzoylcystine | N,N'-dibenzoylcystine: a low molecular weight gelator; structure in first source | ||
| uvaol | uvaol: from Vauquelinia corymbosa (Rosaceae) | triterpenoid | metabolite |
| furamidine | furamidine: RN given refers to parent cpd; WR 199385 refers to di-HCl; pafuramidine is a prodrug of this | ||
| paromomycin | paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis. Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES. | amino cyclitol glycoside; aminoglycoside antibiotic | anthelminthic drug; antibacterial drug; antiparasitic agent; antiprotozoal drug |
| nsc 88915 | 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate): a tyrosyl-DNA phosphodiesterase inhibitor; structure in first source | ||
| nsc 706744 | |||
| puromycin | puromycins | antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor | |
| netilmicin | Netilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. | ||
| (-)-usnic acid | (-)-usnic acid : The (-)-enantiomer of usnic acid. | usnic acid | EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor |
| clindamycin phosphate | |||
| euscaphic acid | euscaphic acid : A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata. euscaphic acid: isolated from medicinal plant, Euscaphis japonica Pax.; structure; RN given refers to 2alpha,3alpha-isomer | hydroxy monocarboxylic acid; pentacyclic triterpenoid; triol | plant metabolite |
| (+)-usnic acid | usnic acid | ||
| isoliquiritigenin | chalcones | antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist | |
| ag-213 | tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells; | ||
| ag 99 | tyrphostin A46: epidermal growth factor-urogastrone receptor antagonist | ||
| ag-490 | catechols; enamide; monocarboxylic acid amide; nitrile; secondary carboxamide | anti-inflammatory agent; antioxidant; apoptosis inducer; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; geroprotector; STAT3 inhibitor | |
| ag 30 | AG 30: structure given in first source; do not confuse with AG-30 antimicrobial peptide | ||
| 3 beta-o-acetylursolic acid | triterpenoid | ||
| corosolic acid | triterpenoid | metabolite | |
| epi-maslinic acid | epi-maslinic acid : A pentacyclic triterpenoid that is 3alpha-hydroxy epimer of maslinic acid. Isolated from Prunella vulgaris and Isodon japonicus, it exhibits anti-inflammatory activity. | dihydroxy monocarboxylic acid; pentacyclic triterpenoid | anti-inflammatory agent; metabolite |
| 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine | 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: psychotropic drug; structure in first source |