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3'-tyrosyl-DNA phosphodiesterase activity

Definition

Target type: molecularfunction

Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA. [PMID:10521354, PMID:16751265]

3'-Tyrosyl-DNA phosphodiesterase activity is a critical molecular function involved in DNA repair mechanisms, specifically in the removal of 3'-tyrosine adducts from DNA. These adducts are commonly formed as a result of oxidative damage or exposure to genotoxic agents. The enzyme catalyzes the hydrolysis of the phosphodiester bond between the 3'-terminal deoxyribose of DNA and the tyrosine residue, effectively releasing the tyrosine adduct and restoring the integrity of the DNA strand. This activity is essential for maintaining genomic stability and preventing mutations that can lead to various diseases.'
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Proteins (1)

ProteinDefinitionTaxonomy
Tyrosyl-DNA phosphodiesterase 1A tyrosyl-DNA phosphodiesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NUW8]Homo sapiens (human)

Compounds (26)

CompoundDefinitionClassesRoles
tyrphostin 25benzenetriol
aurintricarboxylic acidaurintricarboxylic acid : A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.

Aurintricarboxylic Acid: A dye which inhibits protein biosynthesis at the initial stages. The ammonium salt (aluminon) is a reagent for the colorimetric estimation of aluminum in water, foods, and tissues.
monohydroxybenzoic acid;
quinomethanes;
tricarboxylic acid
fluorochrome;
histological dye;
insulin-like growth factor receptor 1 antagonist
framycetinframycetin : A tetracyclic antibacterial agent derived from neomycin, being a glycoside ester of neamine and neobiosamine B.

Framycetin: A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
aminoglycosideallergen;
antibacterial drug;
Escherichia coli metabolite
camptothecinNSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first sourcedelta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol
antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
lividomycinlividomycinsmetabolite
n,n'-dibenzoylcystineN,N'-dibenzoylcystine: a low molecular weight gelator; structure in first source
uvaoluvaol: from Vauquelinia corymbosa (Rosaceae)triterpenoidmetabolite
furamidinefuramidine: RN given refers to parent cpd; WR 199385 refers to di-HCl; pafuramidine is a prodrug of this
paromomycinparomomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.

Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.
amino cyclitol glycoside;
aminoglycoside antibiotic
anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
nsc 889154-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate): a tyrosyl-DNA phosphodiesterase inhibitor; structure in first source
nsc 706744
puromycinpuromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
netilmicinNetilmicin: Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.
(-)-usnic acid(-)-usnic acid : The (-)-enantiomer of usnic acid.usnic acidEC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor
clindamycin phosphate
euscaphic acideuscaphic acid : A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata.

euscaphic acid: isolated from medicinal plant, Euscaphis japonica Pax.; structure; RN given refers to 2alpha,3alpha-isomer
hydroxy monocarboxylic acid;
pentacyclic triterpenoid;
triol
plant metabolite
(+)-usnic acidusnic acid
isoliquiritigeninchalconesantineoplastic agent;
biological pigment;
EC 1.14.18.1 (tyrosinase) inhibitor;
GABA modulator;
geroprotector;
metabolite;
NMDA receptor antagonist
ag-213tyrphostin 47: inhibits protein-tyrosine kinase activity of EGF-R both in vitro and in living cells;
ag 99tyrphostin A46: epidermal growth factor-urogastrone receptor antagonist
ag-490catechols;
enamide;
monocarboxylic acid amide;
nitrile;
secondary carboxamide
anti-inflammatory agent;
antioxidant;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector;
STAT3 inhibitor
ag 30AG 30: structure given in first source; do not confuse with AG-30 antimicrobial peptide
3 beta-o-acetylursolic acidtriterpenoid
corosolic acidtriterpenoidmetabolite
epi-maslinic acidepi-maslinic acid : A pentacyclic triterpenoid that is 3alpha-hydroxy epimer of maslinic acid. Isolated from Prunella vulgaris and Isodon japonicus, it exhibits anti-inflammatory activity.dihydroxy monocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory agent;
metabolite
8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: psychotropic drug; structure in first source