Page last updated: 2024-12-08

db 244

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID445329
CHEMBL ID25999
SCHEMBL ID12348361
MeSH IDM0331499

Synonyms (13)

Synonym
db244
n-cyclopentyl-4-[5-[4-(n-cyclopentylcarbamimidoyl)phenyl]-2-furyl]benzamidine
2,5-bis-[4-cyclopentyl)amidinophenyl]furan
cyclopentyl{[4-(5-{4-[(cyclopentylamino)iminomethyl]phenyl}(2-furyl))phenyl]iminomethyl}amine
D24 ,
CHEMBL25999
n'-cyclopentyl-4-[5-[4-(n'-cyclopentylcarbamimidoyl)phenyl]furan-2-yl]benzenecarboximidamide
benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis[n-cyclopentyl-
192525-51-2
SCHEMBL12348361
DTXSID30332184
db-244
4,4'-(furan-2,5-diyl)bis(n-cyclopentylbenzimidamide)

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"1% of control when administered at a dosage of 10 mumol/kg."( 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
Bender, BC; Boykin, DW; Hall, JE; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD; Xiao, G, 1998
)
0.3
"1% of control when administered at a dosage of 10 micromol/kg."( Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
Bajic, M; Bender, BC; Boykin, DW; Hall, JE; Hopkins, KT; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD, 1998
)
0.3
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (27)

Assay IDTitleYearJournalArticle
AID174183The cysts/g of lung (% of control ) is calculated at a dose of 0.9 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID382521Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 9.4 umol/kg/day, iv relative to control2008European journal of medicinal chemistry, Jan, Volume: 43, Issue:1
Carbamate prodrugs of N-alkylfuramidines.
AID382516Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 33.0 umol/kg/day, po relative to control2008European journal of medicinal chemistry, Jan, Volume: 43, Issue:1
Carbamate prodrugs of N-alkylfuramidines.
AID174178The cysts/g of lung (% of control ) is calculated at a dose of 0.2 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID212859In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.2 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID188639Number of mean cysts/g of lung tissue observed at 9-10 uM/kg/day dose of compound tested in vivo against Pneumocystis carinii pneumonia infected rats2000Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23
DNA minor groove interactions and the biological activity of 2,5-bis.
AID340906Drug level in Trypanosoma brucei brucei S427 at 7.5 uM after 8 hrs2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID212863In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 1.9 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID212709Toxicity at a dose of 0.9 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID192582In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.2 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID212850Toxicity at a dose of 9.4 umol/kg day against Pneumocystis carinii in rats;1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID340903Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID174198The cysts/g of lung (% of control ) is calculated at a dose of 9.4 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID382522Toxicity against immunosuppressed rat pneumocystis model at 33.0 umol/kg/day, po2008European journal of medicinal chemistry, Jan, Volume: 43, Issue:1
Carbamate prodrugs of N-alkylfuramidines.
AID212705Toxicity at a dose of 0.2 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID340904Binding affinity to poly(dA).poly(dT) assessed as increase in melting temperature2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID174187The cysts/g of lung (% of control ) is calculated at a dose of 1.9 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID192585In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 1.9 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID192588In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 9.4 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID340905Binding affinity at d(CGCGAATTCGCG) synthetic oligomer duplex assessed as increase in melting temperature2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID188638Number of mean cysts/g of lung tissue observed at 0.9 uM/kg/day dose of compound tested in vivo against Pneumocystis carinii pneumonia infected rats2000Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23
DNA minor groove interactions and the biological activity of 2,5-bis.
AID212861In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.9 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID340902Antitrypanosomal activity against Trypanosoma brucei brucei S427 after 72 hrs2007Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes.
AID192583In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.9 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
AID7490Cytotoxicity against A2780 ovarian carcinoma cells was evaluated using standard sulforhodamine 96h assay test2000Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23
DNA minor groove interactions and the biological activity of 2,5-bis.
AID212713Toxicity at a dose of 1.9 umol/kg day against Pneumocystis carinii in rats1998Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents.
AID212868In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 9.4 umol/kg/day1998Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]