Page last updated: 2024-12-08
db 244
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 445329 |
| CHEMBL ID | 25999 |
| SCHEMBL ID | 12348361 |
| MeSH ID | M0331499 |
Synonyms (13)
| Synonym |
|---|
| db244 |
| n-cyclopentyl-4-[5-[4-(n-cyclopentylcarbamimidoyl)phenyl]-2-furyl]benzamidine |
| 2,5-bis-[4-cyclopentyl)amidinophenyl]furan |
| cyclopentyl{[4-(5-{4-[(cyclopentylamino)iminomethyl]phenyl}(2-furyl))phenyl]iminomethyl}amine |
| D24 , |
| CHEMBL25999 |
| n'-cyclopentyl-4-[5-[4-(n'-cyclopentylcarbamimidoyl)phenyl]furan-2-yl]benzenecarboximidamide |
| benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis[n-cyclopentyl- |
| 192525-51-2 |
| SCHEMBL12348361 |
| DTXSID30332184 |
| db-244 |
| 4,4'-(furan-2,5-diyl)bis(n-cyclopentylbenzimidamide) |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| "1% of control when administered at a dosage of 10 mumol/kg." | ( 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. Bender, BC; Boykin, DW; Hall, JE; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD; Xiao, G, 1998) | 0.3 |
| "1% of control when administered at a dosage of 10 micromol/kg." | ( Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. Bajic, M; Bender, BC; Boykin, DW; Hall, JE; Hopkins, KT; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD, 1998) | 0.3 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (27)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID174183 | The cysts/g of lung (% of control ) is calculated at a dose of 0.9 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID382521 | Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 9.4 umol/kg/day, iv relative to control | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Carbamate prodrugs of N-alkylfuramidines. |
| AID382516 | Antimicrobial activity against Pneumocystis carinii in immunosuppressed rat assessed as number of cysts/g of lung at 33.0 umol/kg/day, po relative to control | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Carbamate prodrugs of N-alkylfuramidines. |
| AID174178 | The cysts/g of lung (% of control ) is calculated at a dose of 0.2 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID212859 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.2 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID188639 | Number of mean cysts/g of lung tissue observed at 9-10 uM/kg/day dose of compound tested in vivo against Pneumocystis carinii pneumonia infected rats | 2000 | Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23 | DNA minor groove interactions and the biological activity of 2,5-bis. |
| AID340906 | Drug level in Trypanosoma brucei brucei S427 at 7.5 uM after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. |
| AID212863 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 1.9 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID212709 | Toxicity at a dose of 0.9 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID192582 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.2 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID212850 | Toxicity at a dose of 9.4 umol/kg day against Pneumocystis carinii in rats; | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID340903 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. |
| AID174198 | The cysts/g of lung (% of control ) is calculated at a dose of 9.4 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID382522 | Toxicity against immunosuppressed rat pneumocystis model at 33.0 umol/kg/day, po | 2008 | European journal of medicinal chemistry, Jan, Volume: 43, Issue:1 | Carbamate prodrugs of N-alkylfuramidines. |
| AID212705 | Toxicity at a dose of 0.2 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID340904 | Binding affinity to poly(dA).poly(dT) assessed as increase in melting temperature | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. |
| AID174187 | The cysts/g of lung (% of control ) is calculated at a dose of 1.9 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID192585 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 1.9 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID192588 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 9.4 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID340905 | Binding affinity at d(CGCGAATTCGCG) synthetic oligomer duplex assessed as increase in melting temperature | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. |
| AID188638 | Number of mean cysts/g of lung tissue observed at 0.9 uM/kg/day dose of compound tested in vivo against Pneumocystis carinii pneumonia infected rats | 2000 | Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23 | DNA minor groove interactions and the biological activity of 2,5-bis. |
| AID212861 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 0.9 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID340902 | Antitrypanosomal activity against Trypanosoma brucei brucei S427 after 72 hrs | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8 | Diphenyl furans and aza analogs: effects of structural modification on in vitro activity, DNA binding, and accumulation and distribution in trypanosomes. |
| AID192583 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in lung tissue of rats at 0.9 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| AID7490 | Cytotoxicity against A2780 ovarian carcinoma cells was evaluated using standard sulforhodamine 96h assay test | 2000 | Bioorganic & medicinal chemistry letters, Dec-04, Volume: 10, Issue:23 | DNA minor groove interactions and the biological activity of 2,5-bis. |
| AID212713 | Toxicity at a dose of 1.9 umol/kg day against Pneumocystis carinii in rats | 1998 | Journal of medicinal chemistry, Jan-01, Volume: 41, Issue:1 | 2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. |
| AID212868 | In vivo evaluation of iv dosage of the Dicationic furans against Pneumocystis carinii in rats measured 9.4 umol/kg/day | 1998 | Journal of medicinal chemistry, Sep-24, Volume: 41, Issue:20 | Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.50) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||