Page last updated: 2024-09-03

furamidine and pentamidine

furamidine has been researched along with pentamidine in 43 studies

Compound Research Comparison

Studies (furamidine)	Trials (furamidine)	Recent Studies (post-2010) (furamidine)	Studies (pentamidine)	Trials (pentamidine)	Recent Studies (post-2010) (pentamidine)
108	1	32	2,411	136	477

Protein Interaction Comparison

Protein	Taxonomy	pentamidine (IC50)
Solute carrier family 22 member 2	Homo sapiens (human)	1.2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	3.278
Protein tyrosine phosphatase type IVA 3	Homo sapiens (human)	0.3
Solute carrier family 22 member 3	Homo sapiens (human)	9.5
Plasminogen	Homo sapiens (human)	7.3333
Urokinase-type plasminogen activator	Homo sapiens (human)	10
Trypsin-1	Homo sapiens (human)	10
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	2.214
Muscarinic acetylcholine receptor M2	Homo sapiens (human)	1.425
Muscarinic acetylcholine receptor M4	Homo sapiens (human)	1.58
Muscarinic acetylcholine receptor M5	Homo sapiens (human)	2.885
Alpha-2A adrenergic receptor	Homo sapiens (human)	1.375
Cytochrome P450 2D6	Homo sapiens (human)	10
Amine oxidase [flavin-containing] A	Homo sapiens (human)	0.793
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	2.214
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	1.639
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	3.278
D(3) dopamine receptor	Homo sapiens (human)	3.998
Sodium-dependent dopamine transporter	Homo sapiens (human)	3.159
Glutamate receptor ionotropic, NMDA 1	Homo sapiens (human)	0.72
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	10
Glutamate receptor ionotropic, NMDA 2A	Homo sapiens (human)	0.72
Protein tyrosine phosphatase type IVA 2	Homo sapiens (human)	0.3
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	2.7
Protein tyrosine phosphatase type IVA 1	Homo sapiens (human)	0.3
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	1.7033

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.98)	18.7374
1990's	3 (6.98)	18.2507
2000's	22 (51.16)	29.6817
2010's	14 (32.56)	24.3611
2020's	1 (2.33)	2.80

Authors

Authors	Studies
Boykin, DW; Das, BP	1
Clercq, ED; Dann, O	1
Bender, BC; Boykin, DW; Hall, JE; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD; Xiao, G	1
Bajic, M; Bender, BC; Boykin, DW; Hall, JE; Hopkins, KT; Kumar, A; McCurdy, DR; Tidwell, RR; Wilson, WD	1
Bender, BC; Boykin, DW; Hall, JE; McCurdy, DR; Rahmathullah, SM; Tidwell, RR	1
Boykin, DW; Brun, R; Salem, MM; Stephens, CE; Tanious, F; Werbovetz, KA; Wilson, WD	1
Boykin, DW; Brun, R; Easterbrook, JD; Ismail, MA; Tanious, FA; Wilson, WD	1
Boykin, DW; Brun, R; Ismail, MA; Tanious, FA; Wenzler, T; Wilson, WD	1
Arafa, RK; Boykin, DW; Brun, R; Stephens, CE; Tanious, FA; Wenzler, T; Wilson, WD	1
Arafa, RK; Boykin, DW; Bridges, A; Brun, R; Generaux, C; Hall, JE; Ismail, MA; Miao, Y; Wenzler, T; Wilson, WD	1
Barszcz, T; Boykin, DW; Brun, R; Gonzalez, JL; Stephens, CE; Tanious, FA; Wenzler, T; Werbovetz, KA; Wilson, WD	1
Boykin, DW; Hall, JE; Jones, SK; Rahmathullah, SM; Tidwell, RR	1
Brun, R; de Koning, HP; Gould, M; Kaiser, M; Koomen, GJ; Rodenko, B; van der Burg, AM; Wanner, MJ	1
Bakunov, SA; Bakunova, SM; Barzcz, T; Brun, R; Chen, H; Jones, SK; Kumar, EV; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Boykin, DW; Brun, R; Hall, JE; Ismail, MA; Tidwell, RR; Wenzler, T	1
Arafa, RK; Boykin, DW; Brun, R; Hu, L; Ismail, MA; Munde, M; Patel, A; Wenzler, T; Wilson, WD	1
Barghash, Ael-D; Boykin, DW; Brun, R; Eisa, HM; Farahat, AA; Goda, FE; Kumar, A; Liu, Y; Mickelson, L; Say, M; Wenzler, T; Wilson, WD	1
Maciejewska, D; Zołek, T	1
Boykin, DW; Branowska, D; Brun, R; Farahat, AA; Kumar, A; Liu, Y; Wenzler, T; Wilson, WD	1
Bialy, SA; Boykin, DW; Brun, R; Ismail, MA; Nanjunda, R; Wenzler, T; Wilson, WD	1
Barghash, AE; Boykin, DW; Brun, R; Eisa, HM; Farahat, AA; Goda, FE; Kumar, A; Liu, Y; Paliakov, E; Wenzler, T; Wilson, WD	1
Arafa, RK; Boykin, DW; Brun, R; Ismail, MA; Jones, SK; Pandharkar, T; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA; Zhu, X	1
Bakunov, SA; Bakunova, SM; Barszcz, T; Boykin, DW; Brun, R; Jones, SK; Kumar, A; Patrick, DA; Tidwell, RR; Wenzler, T; Werbovetz, KA	1
Bondada, L; Boykin, DW; Brun, R; Hu, L; Munde, M; Patel, A; Wang, MZ; Wenzler, T; Wilson, WD; Yang, S	1
Bakunov, SA; Bakunova, SM; Brun, R; Patrick, DA; Tidwell, RR; Wenzler, T	1
He, M; Ivanov, I; Jassim, BA; Qian, K; Yan, C; Zhang, J; Zheng, YG	1
Davidson, DE; Duxbury, RE; Johnson, AJ; Kinnamon, KE; Masters, RE; Steck, EA	1
Bielawska, A; Bielawski, K	1
Lanteri, CA; Meshnick, SR; Tidwell, RR; Trumpower, BL	1
Bailly, C; Boykin, DW; Kumar, A; Lee, MP; Mallena, S; Neidle, S; Wilson, WD	1
Werbovetz, K	1
Araújo-Jorge, TC; Boykin, DW; De Souza, EM; Hu, Q; Kumar, A; Menna-Barreto, R; Soeiro, MN	1
Boykin, DW; Hall, JE; Holman, JL; Ismail, MA; Mathis, AM; Sturk, LM; Tidwell, RR	1
Agama, KK; Antony, S; Fisher, RJ; Marchand, C; Pommier, Y; Stephen, AG; Thibaut, L	1
Bernhard, SC; Brun, R; Mäser, P; Nerima, B	1
Boykin, DW; Kumar, A; Liu, Y; Wilson, WD	1
Brun, R; Kagira, JM; Karanja, SM; Mdachi, RE; Ngotho, JM; Thuita, JK; Tidwell, R; Wenzler, T	1
Hall, JE; Ju, W; Ming, X; Thakker, DR; Tidwell, RR; Wu, H	1
Generaux, CN; Goldsmith, RB; Gray, DR; Reisner, HM; Tidwell, RR; Yan, Z	1
Barrett, MP; Burchmore, RJ; de Koning, HP; Ward, CP; Wong, PE	1
Boykin, DW; Brun, R; Miller, PN; Wang, MZ; Wenzler, T; Wu, H; Yang, S	1
Choi, G; No, JH; Yang, G	1
Barygin, OI; Zhigulin, AS	1

Reviews

1 review(s) available for furamidine and pentamidine

Article	Year
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents. Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:2 Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Malaria, Falciparum; Pentamidine; Plasmodium falciparum; Prodrugs; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma cruzi; Trypanosomiasis, African	2006

Article

Year

Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.

Current opinion in investigational drugs (London, England : 2000), 2006, Volume: 7, Issue:2

Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Leishmania; Leishmaniasis; Malaria, Falciparum; Pentamidine; Plasmodium falciparum; Prodrugs; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma cruzi; Trypanosomiasis, African

2006

Other Studies

42 other study(ies) available for furamidine and pentamidine

Article	Year
Synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles. Journal of medicinal chemistry, 1977, Volume: 20, Issue:9 Topics: Amidines; Animals; Antiprotozoal Agents; Mice; Plasmodium berghei; Pyrroles; Structure-Activity Relationship; Thiophenes; Trypanosoma	1977
Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors. Journal of medicinal chemistry, 1980, Volume: 23, Issue:7 Topics: Amidines; Animals; Antineoplastic Agents; Kinetics; Leukemia, Experimental; Mice; Moloney murine leukemia virus; Retroviridae; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tilorone	1980
2,5-bis[4-(N-alkylamidino)phenyl]furans as anti-Pneumocystis carinii agents. Journal of medicinal chemistry, 1998, Jan-01, Volume: 41, Issue:1 Topics: Animals; Anti-Infective Agents; Base Sequence; Binding Sites; Furans; Microchemistry; Oligodeoxyribonucleotides; Pneumocystis; Pneumonia, Pneumocystis; Poly dA-dT; Rats	1998
Extended aromatic furan amidino derivatives as anti-Pneumocystis carinii agents. Journal of medicinal chemistry, 1998, Sep-24, Volume: 41, Issue:20 Topics: Amidines; Animals; Antifungal Agents; Drug Evaluation, Preclinical; Furans; Immunosuppression Therapy; Oligodeoxyribonucleotides; Pneumonia, Pneumocystis; Poly dA-dT; Protein Binding; Rats; Structure-Activity Relationship	1998
Prodrugs for amidines: synthesis and anti-Pneumocystis carinii activity of carbamates of 2,5-bis(4-amidinophenyl)furan. Journal of medicinal chemistry, 1999, Sep-23, Volume: 42, Issue:19 Topics: Administration, Oral; Animals; Antifungal Agents; Benzamidines; Carbamates; Models, Chemical; Pneumocystis; Prodrugs; Rats	1999
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12 Topics: Amidines; Animals; DNA; Furans; Guanidine; Inhibitory Concentration 50; Leishmania donovani; Macrophages; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Poly dA-dT; Protozoan Proteins; Structure-Activity Relationship; Temperature; Trypanocidal Agents; Trypanosoma cruzi	2003
Synthesis and antiprotozoal activity of aza-analogues of furamidine. Journal of medicinal chemistry, 2003, Oct-23, Volume: 46, Issue:22 Topics: Animals; Antimalarials; Antiprotozoal Agents; Aza Compounds; Benzamidines; Mice; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2003
Novel dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents. Journal of medicinal chemistry, 2004, Jul-01, Volume: 47, Issue:14 Topics: Animals; Antimalarials; Antiprotozoal Agents; Imidazoles; Mice; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei rhodesiense	2004
Synthesis, DNA affinity, and antiprotozoal activity of fused ring dicationic compounds and their prodrugs. Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17 Topics: Animals; Antiprotozoal Agents; Carbamates; Cations; Circular Dichroism; DNA; Fluorenes; Guanidines; Mice; Plasmodium falciparum; Poly dA-dT; Prodrugs; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2005
Synthesis, DNA affinity, and antiprotozoal activity of linear dications: Terphenyl diamidines and analogues. Journal of medicinal chemistry, 2006, Aug-24, Volume: 49, Issue:17 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Biotransformation; Cations; DNA; Drug Stability; In Vitro Techniques; Liver; Mice; Microsomes; Molecular Structure; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma brucei rhodesiense	2006
Synthesis and antiparasitic evaluation of bis-2,5-[4-guanidinophenyl]thiophenes. European journal of medicinal chemistry, 2007, Volume: 42, Issue:4 Topics: Animals; Antiparasitic Agents; Disease Models, Animal; Guanidines; Leishmania; Mice; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium; Thiophenes; Trypanosoma	2007
Carbamate prodrugs of N-alkylfuramidines. European journal of medicinal chemistry, 2008, Volume: 43, Issue:1 Topics: Animals; Benzamidines; Carbamates; Cysts; Disease Models, Animal; Furans; Lung; Pneumocystis carinii; Pneumonia, Pneumocystis; Prodrugs; Rats	2008
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Adenosine; Animals; Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2007
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes. European journal of medicinal chemistry, 2009, Volume: 44, Issue:9 Topics: Animals; Antiprotozoal Agents; Benzene; Cell Survival; Leishmania donovani; Mice; Myoblasts; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
New treatment option for second-stage African sleeping sickness: in vitro and in vivo efficacy of aza analogs of DB289. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10 Topics: Animals; Benzamidines; Central Nervous System; Female; Furans; Mice; Molecular Structure; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum. Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18 Topics: Animals; Antiprotozoal Agents; Inhibitory Concentration 50; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2009
Synthesis, DNA binding, fluorescence measurements and antiparasitic activity of DAPI related diamidines. Bioorganic & medicinal chemistry, 2010, Jan-15, Volume: 18, Issue:2 Topics: Animals; Apoptosis; Binding Sites; Cells, Cultured; DNA, Protozoan; Drug Evaluation, Preclinical; Fluorescence; Indoles; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Rats; Trypanosoma brucei rhodesiense	2010
Theoretical models of pentamidine analogs activity based on their DNA minor groove complexes. European journal of medicinal chemistry, 2010, Volume: 45, Issue:5 Topics: Binding Sites; DNA; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Nucleic Acid Denaturation; Pentamidine; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature	2010
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles. Bioorganic & medicinal chemistry, 2010, May-15, Volume: 18, Issue:10 Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Protozoan; Drug Stability; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Dicationic phenyl-2,2'-bichalcophenes and analogues as antiprotozoal agents. Bioorganic & medicinal chemistry, 2011, Jan-15, Volume: 19, Issue:2 Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Mice; Pentamidine; Plasmodium falciparum; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2011
Exploration of larger central ring linkers in furamidine analogues: synthesis and evaluation of their DNA binding, antiparasitic and fluorescence properties. Bioorganic & medicinal chemistry, 2011, Apr-01, Volume: 19, Issue:7 Topics: Animals; Antiparasitic Agents; Antiprotozoal Agents; Benzamidines; Benzimidazoles; Circular Dichroism; Cross-Linking Reagents; DNA, Protozoan; Fluorescence; Humans; Mice; Models, Chemical; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanosoma brucei rhodesiense	2011
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inbred Strains; Models, Chemical; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Terphenyl Compounds; Trypanosoma cruzi	2013
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives. European journal of medicinal chemistry, 2013, Volume: 67 Topics: Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Leishmania donovani; Mice; Molecular Structure; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Phenyl Ethers; Plasmodium falciparum; Rats; Structure-Activity Relationship; Trypanosoma brucei rhodesiense; Trypanosomiasis	2013
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues. Bioorganic & medicinal chemistry, 2013, Nov-01, Volume: 21, Issue:21 Topics: Animals; Antiprotozoal Agents; Aza Compounds; Cations; Cell Line; Cell Survival; Disease Models, Animal; Mice; Myoblasts; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Poly dA-dT; Prodrugs; Pyrazines; Rats; Structure-Activity Relationship; Transition Temperature; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2013
Antiprotozoal activity of dicationic 3,5-diphenylisoxazoles, their prodrugs and aza-analogues. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Animals; Antiprotozoal Agents; Isoxazoles; Mice; Molecular Structure; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship; Trypanosomiasis, African	2014
Discovery of Decamidine as a New and Potent PRMT1 Inhibitor. MedChemComm, 2017, Feb-01, Volume: 8, Issue:2 Topics:	2017
Trypanosoma rhodesiense: evaluation of the antitrypanosomal action of 2,5-bis(4-guanylphenyl)furan dihydrochloride. Experimental parasitology, 1982, Volume: 53, Issue:1 Topics: Amidines; Animals; Benzamidines; Female; Macaca mulatta; Male; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1982
Molecular modelling of the interaction of pentamidine analogues with d(CGCGAATTCGCG)2 duplex. Roczniki Akademii Medycznej w Bialymstoku (1995), 2000, Volume: 45 Topics: Benzamidines; DNA; Energy Metabolism; Models, Molecular; Pentamidine; Structure-Activity Relationship	2000
DB75, a novel trypanocidal agent, disrupts mitochondrial function in Saccharomyces cerevisiae. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:10 Topics: Antifungal Agents; Benzamidines; Culture Media; Glycerol; Intracellular Membranes; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Oxygen Consumption; Pentamidine; Saccharomyces cerevisiae; Trypanocidal Agents	2004
Thiophene-based diamidine forms a "super" at binding minor groove agent. Journal of the American Chemical Society, 2004, Oct-27, Volume: 126, Issue:42 Topics: Adenine; Animals; Base Pairing; Benzamidines; Biosensing Techniques; Calorimetry; Cattle; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Crystallography, X-Ray; Deoxyribonuclease I; DNA; DNA Footprinting; Models, Molecular; Nucleic Acid Conformation; Pentamidine; Surface Plasmon Resonance; Thermodynamics; Thiophenes; Thymine; Titrimetry	2004
Antiparasitic activity of aromatic diamidines is related to apoptosis-like death in Trypanosoma cruzi. Parasitology, 2006, Volume: 133, Issue:Pt 1 Topics: Animals; Apoptosis; Benzamidines; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Mice; Parasitic Sensitivity Tests; Pentamidine; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2006
Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:6 Topics: Animals; Benzamidines; Cell Nucleus; Cytoplasm; Dose-Response Relationship, Drug; Fluorescence; Furans; In Vitro Techniques; Kinetics; Male; Mice; Molecular Structure; Organelles; Pentamidine; Tissue Distribution; Trypanocidal Agents; Trypanosoma brucei gambiense	2006
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic acids research, 2007, Volume: 35, Issue:13 Topics: Antineoplastic Agents; Benzamidines; Diminazene; DNA; DNA, Single-Stranded; Drug Evaluation, Preclinical; Electrochemistry; Humans; Kinetics; Luminescent Measurements; Pentamidine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Thymidine	2007
Melarsoprol- and pentamidine-resistant Trypanosoma brucei rhodesiense populations and their cross-resistance. International journal for parasitology, 2007, Volume: 37, Issue:13 Topics: Animals; Antifungal Agents; Benzamidines; Drug Resistance; Female; Melarsoprol; Mice; Parasitic Sensitivity Tests; Pentamidine; Trypanocidal Agents; Trypanosoma brucei rhodesiense	2007
Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove. Biophysical chemistry, 2007, Volume: 131, Issue:1-3 Topics: Antiparasitic Agents; Base Sequence; Benzamidines; Calorimetry, Differential Scanning; Circular Dichroism; DNA; Pentamidine; Poly dA-dT; Thermodynamics; Ultraviolet Rays	2007
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis. Acta tropica, 2008, Volume: 108, Issue:1 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Benzamidines; Female; Humans; Mice; Molecular Structure; Pentamidine; Prodrugs; Trypanosoma brucei gambiense; Trypanosomiasis, African	2008
Transport of dicationic drugs pentamidine and furamidine by human organic cation transporters. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:2 Topics: Antifungal Agents; Benzamidines; Biological Transport; Cations; Female; Glucuronides; Humans; Organic Cation Transport Proteins; Organic Cation Transporter 1; Pentamidine	2009
Application of monoclonal antibodies to measure metabolism of an anti-trypanosomal compound in vitro and in vivo. Journal of clinical laboratory analysis, 2010, Volume: 24, Issue:3 Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Benzamidines; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Hepatocytes; Humans; Immunoglobulin G; Male; Mice; Mice, Inbred BALB C; Pentamidine; Prodrugs; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tandem Mass Spectrometry; Trypanocidal Agents; Trypanosomiasis, African	2010
Trypanocidal furamidine analogues: influence of pyridine nitrogens on trypanocidal activity, transport kinetics, and resistance patterns. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5 Topics: Adenine; Animals; Benzamidines; Biological Transport; Drug Resistance; Female; Nitrogen; Pentamidine; Pyridines; Rats; Trypanocidal Agents	2011
Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Amidines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamidines; Blood-Brain Barrier; Cell Line; Dogs; Furans; Madin Darby Canine Kidney Cells; Male; Mice; Pentamidine; Protein Binding; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2014
Antileishmanial Mechanism of Diamidines Involves Targeting Kinetoplasts. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:11 Topics: Amidines; Benzamidines; DNA Replication; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Kinetoplast; DNA, Mitochondrial; Drug Evaluation, Preclinical; Fluorescence; Leishmania donovani; Molecular Targeted Therapy; Pentamidine; Protozoan Proteins; Topoisomerase II Inhibitors; Trypanocidal Agents	2016
Mechanisms of NMDA Receptor Inhibition by Sepimostat-Comparison with Nafamostat and Diarylamidine Compounds. International journal of molecular sciences, 2023, Oct-27, Volume: 24, Issue:21 Topics: Animals; Cells, Cultured; Guanidines; Hippocampus; N-Methylaspartate; Pentamidine; Rats; Receptors, N-Methyl-D-Aspartate	2023