Compounds > 3-methoxy-7h-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole
Page last updated: 2024-12-07

3-methoxy-7h-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-methoxy-7H-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole: a benzo(e)pyridoindole derivative [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131659
CHEMBL ID439663
SCHEMBL ID2311260
MeSH IDM0220346

Synonyms (17)

Synonym
n~1~-(3-methoxy-8-methyl-7h-benzo[e]pyrido[4,3-b]indol-11-yl)-1,3-propanediamine
n'-[methoxy(methyl)[?]yl]propane-1,3-diamine
3-methoxy-7h-8-methyl-11-((3'-amino)propylamino)benzo(e)pyrido(4,3-b)indole
133712-11-5
1,3-propanediamine, n-(3-methoxy-8-methyl-7h-benzo(e)pyrido(4,3-b)indol-11-yl)-
n-(3-methoxy-8-methyl-7h-benzo(e)pyrido(4,3-b)indol-11-yl)-1,3-propanediamine
mmapa-bepi
nsc664711
nsc-664711
bepi
CHEMBL439663
bepl
SCHEMBL2311260
DTXSID60158339
n'-(5-methoxy-13-methyl-11,15-diazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(10),2(7),3,5,8,12(17),13,15-octaen-16-yl)propane-1,3-diamine
3-methoxy-7h-8-methyl-11-[(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole
AKOS040750783
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID306127Binding affinity to 14C3 DNA triplex assessed as stabilization of triplex DNA form2007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Specific stabilization of DNA triple helices by indolo[2,1-b]quinazolin-6,12-dione derivatives.
AID243248Ratio of maximum concentration bound and specificity sum for triplex nucleic acids2004Journal of medicinal chemistry, Nov-04, Volume: 47, Issue:23
Structural selectivity of aromatic diamidines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (50.00)18.2507
2000's4 (25.00)29.6817
2010's3 (18.75)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.59 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (6.25%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (93.75%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diethyl pyrocarbonate
Diethyl Pyrocarbonate: Preservative for wines, soft drinks, and fruit juices and a gentle esterifying agent.. diethyl pyrocarbonate : The diethyl ester of dicarbonic acid.		3.0910acyclic carboxylic anhydride
quinoxalines
quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.		1.9910mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
alpha-naphthoflavone
alpha-naphthoflavone: inhibits P4501A1 and P4501A2; stimulates some activities of P4503A4. alpha-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).		2.0210extended flavonoid;
naphtho-gamma-pyrone;
organic heterotricyclic compound		aryl hydrocarbon receptor agonist;
aryl hydrocarbon receptor antagonist;
EC 1.14.14.14 (aromatase) inhibitor
Berberine chloride (TN)
[no description available]		2.0210organic molecular entity
ethidium bromide
[no description available]		2.0210organic bromide saltgeroprotector;
intercalator;
trypanocidal drug
coralyne
[no description available]		2.0210
coralyne
coralyne: RN given refers to parent cpd; at this time it is not known for which salt NSC-154890 is synonym; structure; DNA topoisomerse antagonist		2.9840isoquinolines
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.0310copper group element atom;
elemental gold
osmium tetroxide
Osmium Tetroxide: (T-4)-Osmium oxide (OsO4). A highly toxic and volatile oxide of osmium used in industry as an oxidizing agent. It is also used as a histological fixative and stain and as a synovectomy agent in arthritic joints. Its vapor can cause eye, skin, and lung damage.. osmium tetroxide : An osmium coordination entity consisting of four oxygen atoms bound to a central osmium atom via covalent double bonds.		3.0910osmium coordination entityfixative;
histological dye;
oxidising agent;
poison
furamidine
furamidine: RN given refers to parent cpd; WR 199385 refers to di-HCl; pafuramidine is a prodrug of this		2.0210
oligonucleotides
[no description available]		2.9240
echinomycin
Echinomycin: A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis.		3.0910cyclodepsipeptide
ConditionIndicatedRelationship StrengthStudiesTrials
Genome Instability
[description not available]		02.6320
Benign Neoplasms
[description not available]		02.0810
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0810
Chromosome Inversion
An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.		01.9910