Congenital X-Linked Retinoschisis

X chromosome recessive disorder, found nearly exclusively in males and becoming apparent around puberty. Characterized initially by a cystlike structure involving the FOVEA CENTRALIS, a peripheral retinoschisis occurs in about half the patients.

Synonym
Congenital X-Linked Retinoschisis
Retinoschisis, Juvenile, X Chromosome-Linked
Retinoschisis, Juvenile, X-Linked
Retinoschisis, Degenerative
Retinoschisis, X-Linked
Retinoschisis
Retinoschisis X-Linked Juvenile
X-Linked Juvenile Retinoschisis
Retinoschisis, Juvenile
X-Linked Retinoschisis

Excerpt	Reference
"X-linked retinoschisis is the leading cause of macular degeneration in males and leads to splitting within the inner retinal layers leading to visual deterioration."	( Biswas, S; Parry, NR; Sikkink, SK; Stanga, PE; Trump, D, 2007)
"X-linked retinoschisis is a very rare disease in women due to its X-linked recessive inheritance and the foveal cysts associated with it can respond to carbonic anhydrase inhibitors."	( Ali, S; Seth, R, 2013)
"X-linked retinoschisis is one of the more frequently encountered inherited macular retinal disorders affecting young males, causing loss of vision."	( Sadaka, A; Sisk, RA, 2016)

Excerpt	Reference
"To describe a case of X-linked retinoschisis with pseudophakic cystoid macular edema treated by posterior subtenon injection of triamcinolone acetonide."	( Lin, WC; Wang, JK, 2013)
"In the treatment of macular retinoschisis in highly myopic eyes, vitrectomy associated with posterior hyaloid membranes peeling may achieve successful anatomical results."	( Duan, AL; Meng, X; Qi, Y; Wang, N, 2016)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.01)	23.3326
1990's	0 (0.00)	12.5806
2000's	24 (24.24)	18.1394
2010's	63 (63.64)	28.8240
2020's	11 (11.11)	9.53

Drug	Relationship Strength	Studies	Trials
uric acid	low	1	0
acetazolamide	medium	11	1
2-propanol	low	1	0
apnea	low	1	0
serine	low	1	0
triamcinolone diacetate	low	1	0
tryptophan	low	1	0
perflutren	low	24	0
triamcinolone acetonide	low	3	0
thiophenes	low	15	0
c.i. 42510	low	1	0
ethylnitrosourea	low	1	0
sulfur hexafluoride	low	12	0
Brilliant Blue	low	1	0
trolamine salicylate	low	2	0
phenyl acetate	low	1	0
triamcinolone	low	1	0
timolol	low	1	0
paclitaxel	low	1	0
propiconazole	low	1	0
brinzolamide	low	2	0
ouabain	low	1	0
genipin	low	1	0
y 27632	low	1	0
iridoids	low	1	0
digoxin	low	1	0
11-cis-retinal	low	2	0
travoprost	low	1	0
phenylephrine hydrochloride	low	1	0
dorzolamide	low	17	0
cloprostenol	low	1	0
cysteine	low	4	0
silicon	low	1	0
ammonium sulfate	low	1	0
coomassie brilliant blue	low	1	0
jasplakinolide	low	1	0
indocyanine green	low	14	0
sodium ethylxanthate	low	1	0
budesonide, formoterol fumarate drug combination	low	1	0
cytochalasin d	low	1	0
dibutyryl cyclic gmp	low	1	0
eye	low	1	0

Protein Targets (480)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
Chain A, Retinaldehyde-binding protein 1	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	12	0	0	12
GLI family zinc finger 3	13	0	0	13
AR protein	14	0	0	14
aldehyde dehydrogenase 1 family, member A1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	12	0	0	12
retinoid X nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	14	0	0	14
peroxisome proliferator-activated receptor delta	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
Histone H2A.x	3	0	0	3
thyroid hormone receptor beta isoform a	4	0	0	4
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
lamin isoform A-delta10	11	0	0	11
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Glutamate receptor 2	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	3	0	3
thioredoxin reductase	9	0	0	9
GALC protein	2	0	0	2
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
glucocorticoid receptor [Homo sapiens]	14	0	0	14
estrogen-related nuclear receptor alpha	13	0	0	13
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
arylsulfatase A	6	0	0	6
Carbonic anhydrase	0	3	0	3
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
Bloom syndrome protein isoform 1	5	0	0	5
geminin	7	0	0	7
peripheral myelin protein 22	3	0	0	3
survival motor neuron protein isoform d	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	1	1	4
ATP-binding cassette sub-family C member 3	0	8	0	8
Multidrug resistance-associated protein 4	0	8	0	8
Carbonic anhydrase	0	3	0	3
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	4	1	10
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	10	0	10
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 1	0	5	1	13
Carbonic anhydrase 2	0	6	3	15
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Carbonic anhydrase 3	0	4	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	3	0	4
Steryl-sulfatase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
5-hydroxytryptamine receptor 2A	0	3	0	3
Androgen receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit beta-1	2	1	1	4
Translocator protein	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	1	4
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	6	1	11
Carbonic anhydrase 6	0	4	1	9
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	1	4
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	1	4
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	1	4
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	1	4
Adenosine receptor A2a	0	1	0	1
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Cytochrome P450 2C19	0	1	0	1
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	4	1	10
Carbonic anhydrase	0	2	0	3
Kappa-type opioid receptor	0	1	0	1
Carbonic anhydrase 7	0	4	1	9
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	3	0	4
D(2) dopamine receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-3	2	1	1	4
Gamma-aminobutyric acid receptor subunit beta-2	2	1	1	4
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	3	0	3
Mu-type opioid receptor	0	3	0	3
Fatty-acid amide hydrolase 1	0	1	0	1
Beta-carbonic anhydrase 1	0	3	0	3
Carbonic anhydrase 2	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	2
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	5	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	3	0	5
Carbonic anhydrase	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	1	0	1
Carbonic anhydrase	0	3	0	4
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	4	1	6
GABA theta subunit	2	1	1	4
Canalicular multispecific organic anion transporter 1	0	8	0	8
Carbonic anhydrase 4	0	5	0	5
Carbonic anhydrase 15	0	3	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	4	0	7
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	2	1	1	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	4	1	10
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	4	1	10
ATAD5 protein, partial	6	0	0	6
TDP1 protein	11	0	0	11
Microtubule-associated protein tau	2	0	0	2
D(1A) dopamine receptor	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
phosphopantetheinyl transferase	5	0	0	5
NFKB1 protein, partial	3	0	0	3
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	2	0	0	2
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
chromobox protein homolog 1	7	0	0	7
flap endonuclease 1	2	0	0	2
DNA polymerase iota isoform a (long)	3	0	0	3
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	4	0	0	4
Luciferase	3	0	0	3
caspase 7, apoptosis-related cysteine protease	1	0	0	1
pregnane X nuclear receptor	9	0	0	9
caspase-3	1	0	0	1
thyroid stimulating hormone receptor	5	0	0	5
thyroid hormone receptor beta isoform 2	6	0	0	6
histone deacetylase 9 isoform 3	1	0	0	1
ATPase family AAA domain-containing protein 5	8	0	0	8
Ataxin-2	8	0	0	8
Pannexin-1	0	1	0	1
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
cytochrome P450 2D6	3	0	0	3
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
progesterone receptor	9	0	0	9
peroxisome proliferator activated receptor gamma	8	0	0	8
nuclear receptor subfamily 1, group I, member 2	4	0	0	4
Cellular tumor antigen p53	9	0	0	9
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostacyclin receptor	0	1	0	1
Prostaglandin D2 receptor	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Cruzipain	1	0	0	1
interleukin 8	2	0	0	2
PAX8	0	0	0	1
SMAD family member 2	5	0	0	5
PPM1D protein	2	0	0	2
SMAD family member 3	5	0	0	5
STAT3, partial	0	2	0	2
thioredoxin glutathione reductase	3	0	0	3
Smad3	2	0	0	2
estrogen receptor 2 (ER beta)	4	0	0	4
regulator of G-protein signaling 4	3	0	0	3
farnesoid X nuclear receptor	4	0	0	4
67.9K protein	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Interferon beta	4	0	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	4	0	5
Sodium/potassium-transporting ATPase subunit beta-1	0	4	0	5
Integrin beta-3	1	1	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	5
Integrin alpha-IIb	1	0	0	1
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	3
ATP-dependent translocase ABCB1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	4	0	5
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Nuclear receptor ROR-gamma	1	1	1	3
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	3	0	3
pregnane X receptor	3	0	0	3
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
Tyrosine-protein phosphatase non-receptor type 2	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 11	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
Kruppel-like factor 5	0	1	0	1
peripheral myelin protein 22 isoform 1	3	0	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Genome polyprotein	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	1
Substance-K receptor	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Delta-type opioid receptor	0	2	0	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
glp-1 receptor, partial	3	0	0	3
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
Spike glycoprotein	1	0	0	1
luciferase	0	0	0	1
aryl hydrocarbon receptor	4	0	0	4
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	6	1	12
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Histamine H1 receptor	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	2
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Proton-coupled amino acid transporter 1	0	2	0	2
Amino acid transporter	0	2	0	2
Chain A, Ferritin light chain	1	0	0	1
nonstructural protein 1	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
vitamin D3 receptor isoform VDRA	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Histamine H2 receptor	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
TAR DNA-binding protein 43	2	0	0	2
heat shock protein 90, putative	0	0	0	1
DNA polymerase kappa isoform 1	1	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Beta-1 adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Beta-2 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Beta-2 adrenergic receptor	0	0	1	1
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Plasma kallikrein	0	0	0	1
Myeloperoxidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
SLC16A10 protein	0	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Tryprostatin B synthase	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Monocarboxylate transporter 10	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
Phospholipase A-2-activating protein	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain E, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor, alpha form	0	1	0	1
Chain B, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunit	0	1	0	1
Chain I, cAMP-dependent protein kinase inhibitor alpha	0	1	0	1
Chain A, Rho-associated protein kinase 1	0	1	0	1
dopamine D1 receptor	1	0	0	1
EWS/FLI fusion protein	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Rho-associated protein kinase 2	0	2	0	2
Ribosomal protein S6 kinase alpha-5	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
C-C motif chemokine 2	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Rho-associated protein kinase 1	0	2	0	2
Serine/threonine-protein kinase N2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Congenital X-Linked Retinoschisis

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (99)

Protein Targets (480)

Congenital X-Linked Retinoschisis

Synonyms(10)

Research Excerpts

Overview

Treatment

Research

Studies (99)

Drugs Studied (47)

Protein Targets (480)