Page last updated: 2024-09-28

Adie Pupil

A pupillary abnormality characterized by a poor pupillary light reaction, reduced accommodation, iris sector palsies, an enhanced pupillary response to near effort that results in a prolonged, tonic constriction, and slow pupillary redilation. This condition is associated with injury to the postganglionic parasympathetic innervation to the pupil. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp492-500)

Synonyms(8)

Synonym
Adie Pupil
Pupillotonia
Pupil, Tonic
Tonic Pupil
Tonic Pupil, Local
Adie's Pupil
Myotonic Pupil
Tonic Pupil, Neuropathic

Research Excerpts

Treatment

Excerpt	Reference
"Large iris defets, anirdia or wide atonic pupil may cause disturbing photoptic phenomena my require surgical treatment."	( Wilczynski, M, 2015)
"Bilateral Adie's tonic pupils were improved by IVIg drip infusion and methylprednisolone pulse therapy."	( Fujita, A; Kajikawa, S; Kusunoki, S; Ohi, T, 2016)

Research

Studies (56)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (21.43)	23.3326
1990's	9 (16.07)	12.5806
2000's	21 (37.50)	18.1394
2010's	11 (19.64)	28.8240
2020's	3 (5.36)	9.53

Drug	Relationship Strength	Studies	Trials
apraclonidine	low	1	0
azathioprine	low	1	0
bethanechol	low	1	0
clonidine	low	1	0
erythrosine	low	1	0
foscarnet	low	1	0
ibuprofen	low	1	0
lidocaine	low	1	0
2-propanol	low	11	0
tetracaine	low	1	0
tyramine	low	2	0
prednisolone	low	2	0
prednisone	low	3	0
penicillin g	low	1	0
pilocarpine	medium	23	1
phenylephrine	low	2	0
methacholine chloride	low	2	0
pyridostigmine bromide	low	1	0
glycopyrrolate	low	1	0
fluorescein	low	1	0
titanium	low	1	0
propiconazole	low	1	0
fomesafen	low	8	0
3-iodobenzylguanidine	low	1	0
tamsulosin	low	1	0
cocaine	low	2	0
oxycodone	low	1	0
eye	low	7	0

Protein Targets (473)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	5	0	0	5
RAR-related orphan receptor gamma	8	0	0	8
GLI family zinc finger 3	8	0	0	8
AR protein	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	4	0	0	4
retinoic acid nuclear receptor alpha variant 1	7	0	0	7
retinoid X nuclear receptor alpha	8	0	0	8
estrogen nuclear receptor alpha	12	0	0	12
peroxisome proliferator-activated receptor delta	5	0	0	5
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	4	0	0	4
thyroid hormone receptor beta isoform a	3	0	0	3
heat shock protein beta-1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	5	0	0	5
dopamine D1 receptor	3	0	0	3
thioredoxin reductase	5	0	0	5
GLS protein	6	0	0	6
Thrombopoietin	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
cytochrome P450 2D6 isoform 1	2	0	0	2
cytochrome P450 2C19 precursor	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
lethal factor (plasmid)	1	0	0	1
POU domain, class 2, transcription factor 1	0	0	0	2
Spike glycoprotein	4	0	0	4
ATP-dependent phosphofructokinase	5	0	0	5
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
NFKB1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	2	0	0	2
regulator of G-protein signaling 4	6	0	0	6
muscarinic acetylcholine receptor M1	6	0	0	6
Alpha-2A adrenergic receptor	0	6	3	9
Alpha-2B adrenergic receptor	0	4	2	6
Alpha-2C adrenergic receptor	0	6	3	9
Alpha-2B adrenergic receptor	0	6	1	7
Alpha-1D adrenergic receptor	0	5	3	8
Adenosine receptor A2b	0	0	2	2
Adenosine receptor A2a	0	1	2	3
Alpha-1A adrenergic receptor	0	5	5	10
Alpha-1B adrenergic receptor	0	5	5	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Ferritin light chain	4	0	0	4
interleukin 8	1	0	0	1
acetylcholinesterase	6	0	0	6
phosphopantetheinyl transferase	3	0	0	3
SMAD family member 2	4	0	0	4
ATAD5 protein, partial	2	0	0	2
Fumarate hydratase	2	0	0	2
SMAD family member 3	4	0	0	4
TDP1 protein	8	0	0	8
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
EWS/FLI fusion protein	2	0	0	2
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	10	0	0	10
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	7	0	0	7
G	3	0	0	3
polyprotein	2	0	0	2
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	5	0	0	5
arylsulfatase A	5	0	0	5
IDH1	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
aryl hydrocarbon receptor	6	0	0	6
thyroid stimulating hormone receptor	3	0	0	3
Bloom syndrome protein isoform 1	4	0	0	4
peripheral myelin protein 22 isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
thyroid hormone receptor beta isoform 2	6	0	0	6
DNA polymerase iota isoform a (long)	3	0	0	3
geminin	6	0	0	6
peripheral myelin protein 22	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	3	0	0	3
M-phase phosphoprotein 8	2	0	0	2
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	3	0	0	3
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Bile salt export pump	0	2	0	2
Bile salt export pump	0	9	0	9
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
Cellular tumor antigen p53	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit delta	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	3	0	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	3	0	0	3
Nuclear receptor ROR-gamma	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-3	3	0	0	3
Gamma-aminobutyric acid receptor subunit beta-2	3	0	0	3
GABA theta subunit	3	0	0	3
Inositol hexakisphosphate kinase 1	3	0	0	3
Canalicular multispecific organic anion transporter 1	0	4	0	4
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Gamma-aminobutyric acid receptor subunit epsilon	3	0	0	3
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	3	0	0	3
USP1 protein, partial	2	0	0	2
chromobox protein homolog 1	5	0	0	5
flap endonuclease 1	2	0	0	2
Muscarinic acetylcholine receptor M2	0	4	1	5
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	3	0	3
Muscarinic acetylcholine receptor M1	0	3	2	5
Muscarinic acetylcholine receptor M3	0	3	0	3
Chain A, Cruzipain	1	0	0	1
cytochrome P450 2D6	5	0	0	5
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
cytochrome P450 2C9 precursor	2	0	0	2
Membrane primary amine oxidase	0	1	0	1
Solute carrier family 22 member 1	0	3	0	5
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Alpha-1B adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	2	2	4
D	0	2	0	2
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	1	4
Amine oxidase [flavin-containing] A	0	2	0	3
Alpha-2C adrenergic receptor	0	4	1	5
Alpha-2A adrenergic receptor	0	4	1	5
Alpha-1D adrenergic receptor	0	3	0	3
D(1B) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
Alpha-2B adrenergic receptor	0	0	0	2
D(4) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	1	4
Histamine H2 receptor	3	0	0	3
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Inositol monophosphatase 1	2	0	0	2
Alpha-2C adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	0	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Nischarin	0	1	0	1
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	4
5-hydroxytryptamine receptor 2C	0	2	1	3
Tryptophan 5-hydroxylase 1	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	3
5-hydroxytryptamine receptor 7	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	1	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Leukotriene B4 receptor 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	1	2
Leukotriene B4 receptor 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Transporter	0	2	0	2
Chain A, Beta-lactamase	4	0	0	4
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Genome polyprotein	0	1	1	2
Luciferase	3	0	0	3
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
thyrotropin-releasing hormone receptor	3	0	0	3
vitamin D3 receptor isoform VDRA	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA polymerase kappa isoform 1	3	0	0	3
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
progesterone receptor	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	1	0	0	1
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
Carbonic anhydrase 1	0	0	0	1
Carbonic anhydrase 2	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 9	0	1	0	1
Reverse transcriptase/RNaseH	0	1	1	2
nonstructural protein 1	3	0	0	3
67.9K protein	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
importin subunit beta-1 isoform 1	1	0	0	1
snurportin-1	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Albumin	0	1	1	2
Albumin	0	1	0	1
Albumin	0	0	1	1
Prostaglandin G/H synthase 1	0	2	0	2
Cholinesterase	0	1	0	1
Cytochrome P450 2C9	0	3	0	3
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Caspase-1	0	1	0	1
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 2J2	0	2	0	2
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Fatty-acid amide hydrolase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
mitogen-activated protein kinase 1	2	0	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	3	0	3
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	2	0	2
glp-1 receptor, partial	3	0	0	3
GALC protein	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
galanin receptor type 3	0	1	0	1
PPM1D protein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Glucocorticoid receptor	0	6	2	13
Glycine receptor subunit alpha-1	0	6	0	6
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Acetylcholinesterase	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	1	2
Delta-type opioid receptor	0	0	1	1
Kappa-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	0	1	1
Mu-type opioid receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
streptokinase A precursor	0	0	1	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase TEM	0	1	0	2
Guanine nucleotide-binding protein G	2	0	0	2
Beta-lactamase	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase VIM-1	0	0	0	1
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	2	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M2	0	2	0	3
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	2	0	0	2
nuclear receptor ROR-gamma isoform 1	3	0	0	3
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Cytochrome P450 3A4	0	1	0	1
heat shock protein 90, putative	0	0	0	1
endonuclease IV	1	0	0	1
alpha-galactosidase	1	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
cGMP-gated cation channel alpha-1	0	0	1	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	1	0	0	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Polyphenol oxidase 2	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
D(1A) dopamine receptor	0	1	0	2
5-hydroxytryptamine receptor 3A	0	0	1	1
Beta-secretase 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Histamine H3 receptor	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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