Page last updated: 2024-09-28

Adie Pupil

A pupillary abnormality characterized by a poor pupillary light reaction, reduced accommodation, iris sector palsies, an enhanced pupillary response to near effort that results in a prolonged, tonic constriction, and slow pupillary redilation. This condition is associated with injury to the postganglionic parasympathetic innervation to the pupil. (From Miller et al., Clinical Neuro-Ophthalmology, 4th ed, pp492-500)

Synonyms(8)

Synonym
Adie Pupil
Pupillotonia
Pupil, Tonic
Tonic Pupil
Tonic Pupil, Local
Adie's Pupil
Myotonic Pupil
Tonic Pupil, Neuropathic

Research Excerpts

Treatment

ExcerptReference
"Large iris defets, anirdia or wide atonic pupil may cause disturbing photoptic phenomena my require surgical treatment."( Wilczynski, M, 2015)
"Bilateral Adie's tonic pupils were improved by IVIg drip infusion and methylprednisolone pulse therapy."( Fujita, A; Kajikawa, S; Kusunoki, S; Ohi, T, 2016)

Research

Studies (56)

TimeframeStudies, This Condition (%)All Conditions %
pre-199012 (21.43)23.3326
1990's9 (16.07)12.5806
2000's21 (37.50)18.1394
2010's11 (19.64)28.8240
2020's3 (5.36)9.53
DrugIndicatedRelationship StrengthStudiesTrials
apraclonidine0low10
azathioprine0low10
bethanechol0low10
clonidine0low10
erythrosine0low10
foscarnet0low10
ibuprofen0low10
lidocaine0low10
2-propanol0low110
tetracaine0low10
tyramine0low20
prednisolone0low20
prednisone0low30
penicillin g0low10
pilocarpine0medium231
phenylephrine0low20
methacholine chloride0low20
pyridostigmine bromide0low10
glycopyrrolate0low10
fluorescein0low10
titanium0low10
propiconazole0low10
fomesafen0low80
3-iodobenzylguanidine0low10
tamsulosin0low10
cocaine0low20
oxycodone0low10
eye0low70

Protein Targets (473)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit5005
RAR-related orphan receptor gamma8008
GLI family zinc finger 38008
AR protein120012
aldehyde dehydrogenase 1 family, member A14004
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha8008
estrogen nuclear receptor alpha120012
peroxisome proliferator-activated receptor delta5005
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
activating transcription factor 64004
v-jun sarcoma virus 17 oncogene homolog (avian)7007
Histone H2A.x4004
thyroid hormone receptor beta isoform a3003
heat shock protein beta-13003
nuclear factor erythroid 2-related factor 2 isoform 17007
lamin isoform A-delta108008
Voltage-dependent calcium channel gamma-2 subunit5005
Glutamate receptor 25005
dopamine D1 receptor3003
thioredoxin reductase5005
GLS protein6006
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
cytochrome P450 2D6 isoform 12002
cytochrome P450 2C19 precursor4004
ras-related protein Rab-9A2002
histone acetyltransferase KAT2A isoform 14004
lethal factor (plasmid)1001
POU domain, class 2, transcription factor 10002
Spike glycoprotein4004
ATP-dependent phosphofructokinase5005
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
NFKB1 protein, partial3003
thyroid stimulating hormone receptor2002
regulator of G-protein signaling 46006
muscarinic acetylcholine receptor M16006
Alpha-2A adrenergic receptor0639
Alpha-2B adrenergic receptor0426
Alpha-2C adrenergic receptor0639
Alpha-2B adrenergic receptor0617
Alpha-1D adrenergic receptor0538
Adenosine receptor A2b0022
Adenosine receptor A2a0123
Alpha-1A adrenergic receptor05510
Alpha-1B adrenergic receptor05510
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE7007
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, Ferritin light chain4004
interleukin 81001
acetylcholinesterase6006
phosphopantetheinyl transferase3003
SMAD family member 24004
ATAD5 protein, partial2002
Fumarate hydratase2002
SMAD family member 34004
TDP1 protein8008
Microtubule-associated protein tau4004
thioredoxin glutathione reductase3003
nuclear receptor subfamily 1, group I, member 34004
EWS/FLI fusion protein2002
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha100010
farnesoid X nuclear receptor4004
pregnane X nuclear receptor7007
G3003
polyprotein2002
P531001
peroxisome proliferator activated receptor gamma5005
arylsulfatase A5005
IDH14004
euchromatic histone-lysine N-methyltransferase 2110011
aryl hydrocarbon receptor6006
thyroid stimulating hormone receptor3003
Bloom syndrome protein isoform 14004
peripheral myelin protein 22 isoform 11001
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a1001
thyroid hormone receptor beta isoform 26006
DNA polymerase iota isoform a (long)3003
geminin6006
peripheral myelin protein 222002
survival motor neuron protein isoform d2002
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3003
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Bile salt export pump0202
Bile salt export pump0909
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 3003
Cellular tumor antigen p538008
Gamma-aminobutyric acid receptor subunit beta-13003
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
Gamma-aminobutyric acid receptor subunit alpha-63003
Nuclear receptor ROR-gamma2002
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
GABA theta subunit3003
Inositol hexakisphosphate kinase 13003
Canalicular multispecific organic anion transporter 10404
ATPase family AAA domain-containing protein 54004
Ataxin-24004
Gamma-aminobutyric acid receptor subunit epsilon3003
Protein-arginine deiminase type-40101
cytochrome P450 2C9, partial3003
USP1 protein, partial2002
chromobox protein homolog 15005
flap endonuclease 12002
Muscarinic acetylcholine receptor M20415
Muscarinic acetylcholine receptor M40202
Muscarinic acetylcholine receptor M50303
Muscarinic acetylcholine receptor M10325
Muscarinic acetylcholine receptor M30303
Chain A, Cruzipain1001
cytochrome P450 2D65005
Beta-1 adrenergic receptor 0011
Alpha-1B adrenergic receptor 0022
cytochrome P450 2C9 precursor2002
Membrane primary amine oxidase 0101
Solute carrier family 22 member 1 0305
5-hydroxytryptamine receptor 3A0011
Solute carrier family 22 member 30202
5-hydroxytryptamine receptor 1A0202
Alpha-1B adrenergic receptor0202
Alpha-1A adrenergic receptor0224
D0202
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0314
Amine oxidase [flavin-containing] A0203
Alpha-2C adrenergic receptor0415
Alpha-2A adrenergic receptor0415
Alpha-1D adrenergic receptor0303
D(1B) dopamine receptor0101
Amine oxidase [flavin-containing] B0102
5-hydroxytryptamine receptor 1B0314
Alpha-2B adrenergic receptor0002
D(4) dopamine receptor0101
Delta-type opioid receptor0101
Alpha-1A adrenergic receptor0314
Histamine H2 receptor3003
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0202
Mu-type opioid receptor0202
Inositol monophosphatase 12002
Alpha-2C adrenergic receptor0002
Alpha-2A adrenergic receptor0002
Alpha-2A adrenergic receptor0101
Nischarin0202
Solute carrier family 22 member 10101
Multidrug and toxin extrusion protein 10202
Nischarin0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Amyloid-beta precursor protein0101
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Muscarinic acetylcholine receptor M10304
5-hydroxytryptamine receptor 2C0213
Tryptophan 5-hydroxylase 10202
5-hydroxytryptamine receptor 2A0213
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Liver carboxylesterase 10001
Sodium-dependent noradrenaline transporter 0202
Sodium-dependent dopamine transporter0303
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Gamma-aminobutyric acid receptor subunit beta-30101
5-hydroxytryptamine receptor 1D0112
5-hydroxytryptamine receptor 1F0112
5-hydroxytryptamine receptor 2B0213
5-hydroxytryptamine receptor 60112
Gamma-aminobutyric acid receptor subunit alpha-50101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0203
5-hydroxytryptamine receptor 7 0112
Gamma-aminobutyric acid receptor subunit alpha-30101
5-hydroxytryptamine receptor 5A0112
5-hydroxytryptamine receptor 5B0112
Glutamate receptor ionotropic, NMDA 1 0101
5-hydroxytryptamine receptor 3A0112
Lysosomal Pro-X carboxypeptidase0101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit epsilon0101
Glutamate receptor ionotropic, NMDA 2A 0101
Glutamate receptor ionotropic, NMDA 2B0101
Glutamate receptor ionotropic, NMDA 2C0101
Sodium-dependent dopamine transporter 0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
Potassium voltage-gated channel subfamily H member 20303
Leukotriene B4 receptor 10101
Gamma-aminobutyric acid receptor subunit alpha-60101
Sodium-dependent dopamine transporter0202
Glutamate receptor ionotropic, NMDA 2D0101
5-hydroxytryptamine receptor 4 0112
Gamma-aminobutyric acid receptor subunit gamma-10101
Glutamate receptor ionotropic, NMDA 3B0101
Sigma non-opioid intracellular receptor 10505
Gamma-aminobutyric acid receptor subunit gamma-30101
5-hydroxytryptamine receptor 3B0112
Leukotriene B4 receptor 20101
Glutamate receptor ionotropic, NMDA 3A0101
Gamma-aminobutyric acid receptor subunit theta0101
Transporter0202
Chain A, Beta-lactamase4004
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Genome polyprotein 0112
Luciferase3003
chaperonin-containing TCP-1 beta subunit homolog1001
hypothetical protein, conserved1001
cytochrome P450 family 3 subfamily A polypeptide 45005
bromodomain adjacent to zinc finger domain 2B2002
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
thyrotropin-releasing hormone receptor3003
vitamin D3 receptor isoform VDRA4004
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eyes absent homolog 2 isoform a1001
lethal(3)malignant brain tumor-like protein 1 isoform I2002
DNA polymerase kappa isoform 13003
relaxin receptor 1 isoform 11001
Flavin reductase (NADPH)0011
large T antigen0101
estrogen receptor 2 (ER beta)3003
progesterone receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Chain A, probable fosfomycin resistance protein0011
Chain B, probable fosfomycin resistance protein0011
Carbonic anhydrase 10001
Carbonic anhydrase 20101
DNA polymerase catalytic subunit0101
DNA polymerase catalytic subunit0101
DNA polymerase alpha catalytic subunit0101
Carbonic anhydrase 40101
DNA polymerase delta catalytic subunit0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 90101
Reverse transcriptase/RNaseH 0112
nonstructural protein 13003
67.9K protein1001
transcriptional regulator ERG isoform 31001
importin subunit beta-1 isoform 11001
snurportin-11001
Acid-sensing ion channel 30101
Solute carrier organic anion transporter family member 1A40101
Solute carrier family 22 member 60202
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Dihydrofolate reductase0101
Epidermal growth factor receptor0101
Fatty acid-binding protein, liver0202
Albumin0112
Albumin0101
Albumin0011
Prostaglandin G/H synthase 10202
Cholinesterase0101
Cytochrome P450 2C9 0303
Fatty acid-binding protein, intestinal0101
Polyunsaturated fatty acid 5-lipoxygenase0102
UDP-glucuronosyltransferase 2B70001
Acetylcholinesterase0202
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Adenosine receptor A10101
Caspase-10101
Substance-P receptor0101
Prostaglandin G/H synthase 20202
Prostaglandin G/H synthase 2 0102
UDP-glucuronosyltransferase 1A30001
Aldo-keto reductase family 1 member C30101
Caspase-30101
Solute carrier organic anion transporter family member 1A10101
Caspase-40101
4-aminobutyrate aminotransferase, mitochondrial0101
Cytochrome P450 2J20202
Caspase-50101
Caspase-90101
Acid-sensing ion channel 10101
Prostaglandin G/H synthase 20202
Fatty-acid amide hydrolase 10101
Prostaglandin G/H synthase 20101
TAR DNA-binding protein 432002
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Solute carrier family 22 member 200101
Solute carrier family 22 member 80202
Solute carrier family 22 member 60101
Dehydrogenase/reductase SDR family member 90101
mitogen-activated protein kinase 12002
Potassium channel subfamily K member 30202
Potassium channel subfamily K member 20101
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 3 subunit alpha0101
Potassium voltage-gated channel subfamily A member 50101
Sodium channel protein type 4 subunit alpha0101
Sodium channel protein type 5 subunit alpha0202
Sodium channel protein type 9 subunit alpha0303
Potassium voltage-gated channel subfamily D member 20101
Potassium channel subfamily K member 180101
Sodium channel protein type 3 subunit alpha0202
glp-1 receptor, partial3003
GALC protein1001
nuclear factor erythroid 2-related factor 2 isoform 24004
galanin receptor type 30101
PPM1D protein1001
nuclear receptor subfamily 1, group I, member 22002
Nuclear receptor subfamily 1 group I member 20011
Glucocorticoid receptor06213
Glycine receptor subunit alpha-10606
Androgen receptor0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Nuclear receptor subfamily 1 group I member 20011
Acetylcholinesterase0101
Delta-type opioid receptor0101
Kappa-type opioid receptor0011
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
Mu-type opioid receptor0112
Delta-type opioid receptor0011
Kappa-type opioid receptor0102
Kappa-type opioid receptor0011
Mu-type opioid receptor0011
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase type 20001
Metallo-beta-lactamase VIM-11 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-19 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-beta-lactamase0001
Beta-lactamase 0001
streptokinase A precursor0011
Beta-lactamase0001
Solute carrier family 22 member 80102
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase0001
Beta-lactamase SHV-10001
Beta-lactamase SHV-10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Solute carrier family 15 member 10101
Beta-lactamase TEM0102
Guanine nucleotide-binding protein G2002
Beta-lactamase0001
B2 metallo-beta-lactamase 0001
Solute carrier family 15 member 20101
Metallo-beta-lactamase VIM-130001
Beta-lactamase 0001
Beta-lactamase 0001
Efflux transporter 0001
Beta-lactamase 0001
Metallo-beta-lactamase VIM-20001
Beta-lactamase Toho-10001
Beta-lactamase 0001
Beta-lactamase 0001
Class D beta-lactamase0001
Beta-lactamase 0001
Solute carrier family 15 member 20101
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Metallo-b-lactamase 0001
Beta-lactamase IMP-1 0001
BlaVIM-1 0001
Beta-lactamase 0001
Beta-lactamase 0001
Beta-lactamase 0001
Carbapenem-hydrolyzing beta-lactamase KPC0001
Beta-lactamase class B VIM-2 0001
Beta-lactamase 0001
Solute carrier family 22 member 80102
Beta-lactamase VIM-1 0001
D(1A) dopamine receptor1001
Beta-2 adrenergic receptor0011
Beta-1 adrenergic receptor0011
Beta-3 adrenergic receptor0011
Beta-1 adrenergic receptor0101
Alpha-1B adrenergic receptor0202
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
Muscarinic acetylcholine receptor M30203
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M20203
Cytochrome P450 2A60112
Muscarinic acetylcholine receptor M10011
Muscarinic acetylcholine receptor DM10101
Cytochrome P450 2A130112
luciferase0001
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Estrogen receptor beta0202
pregnane X receptor2002
nuclear receptor ROR-gamma isoform 13003
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Cytochrome P450 3A40101
heat shock protein 90, putative0001
endonuclease IV1001
alpha-galactosidase1001
Alpha-1A adrenergic receptor0112
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 70101
D(3) dopamine receptor0101
Alpha-1D adrenergic receptor0101
Alpha-1B adrenergic receptor0101
Alpha-1A adrenergic receptor0101
5-hydroxytryptamine receptor 40202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
cGMP-gated cation channel alpha-10011
Sodium channel protein type 7 subunit alpha0101
Sodium channel protein type 2 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Chain A, 2-oxoglutarate Oxygenase1001
guanine nucleotide-binding protein subunit alpha-150112
D(3) dopamine receptor isoform e1001
trace amine-associated receptor 10112
Polyphenol oxidase 20001
Phenylethanolamine N-methyltransferase0101
Dopamine beta-hydroxylase 0001
D(1A) dopamine receptor0102
5-hydroxytryptamine receptor 3A0011
Beta-secretase 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Histamine H3 receptor0001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]