7-oxo-ganoderic acid Z: from the mushroom Ganoderma lucidum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 71461154 |
| CHEMBL ID | 2203597 |
| MeSH ID | M0505072 |
| Synonym |
|---|
| CHEMBL2203597 , |
| bdbm50104752 |
| 7-oxo-ganoderic acid z |
| HY-N10930 |
| CS-0637585 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 (µMol) | 22.3000 | 0.0000 | 0.7949 | 8.9000 | AID1235936 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| protein binding | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| GTPase regulator activity | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| NADPH binding | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| coenzyme A binding | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| peroxisomal membrane | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| endoplasmic reticulum | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| endoplasmic reticulum membrane | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| endoplasmic reticulum membrane | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| peroxisomal membrane | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID711441 | Cytotoxicity against human HeLa cells | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Lanostanoids from fungi: a group of potential anticancer compounds. |
| AID1235936 | Inhibition of HMG-CoA reductase (unknown origin) | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.28) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||