Page last updated: 2024-12-11

poricoic acid g

Description

poricoic acid G: from Poria cocos (Polyporaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
CocosgenusA plant genus of the family ARECACEAE. It is a tropical palm tree that yields a large, edible hard-shelled fruit from which oil and fiber are also obtained.[MeSH]ArecaceaeThe palm family of order Arecales, subclass Arecidae, class Liliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID5471966
CHEMBL ID138450
CHEBI ID68355
SCHEMBL ID6281406
MeSH IDM0425218

Synonyms (18)

Synonym
16.alpha.-hydroxy-3,8,24-triene-3,21-dioic acid
NCI60_039950
nsc715639
nsc-715639
poricoic acid g
CHEMBL138450
chebi:68355 ,
(2r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-prop-1-en-2-yl-1,2,3,4,5,7,8,9-octahydrocyclopenta[a]naphthalen-3-yl]-6-methylhept-5-enoic acid
inchi=1/c30h46o5/c1-18(2)9-8-10-20(27(34)35)26-24(31)17-30(7)23-12-11-21(19(3)4)28(5,15-14-25(32)33)22(23)13-16-29(26,30)6/h9,20-21,24,26,31h,3,8,10-17h2,1-2,4-7h3,(h,32,33)(h,34,35)/t20-,21+,24-,26+,28+,29-,30+/m1/s1
16alpha-hydroxy-3,4-seco-lanosta-4(28),8,24-triene-3,21-dioic acid
(2r)-2-[(2r,3r,3ar,6s,7s,9br)-6-(2-carboxyethyl)-2-hydroxy-3a,6,9b-trimethyl-7-(prop-1-en-2-yl)-2,3,3a,4,5,6,7,8,9,9b-decahydro-1h-cyclopenta[a]naphthalen-3-yl]-6-methylhept-5-enoic acid
SCHEMBL6281406
415724-84-4
Q27136852
AKOS040763450
HY-N10071
FS-8183
CS-0255439
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
fungal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
dicarboxylic acidAny carboxylic acid containing two carboxy groups.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
tricyclic triterpenoid
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID472364Cytotoxicity against human CRL1579 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
AID338912Growth inhibition of human HL60 cells after 48 hrs by sulforhodamine B assay2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591408Cytotoxicity in human PANC1 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID591407Cytotoxicity in human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338909Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 100 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591406Cytotoxicity in human DU145 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338911Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591409Cytotoxicity in human CRL1579 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID472363Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos.
AID338907Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 1000 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591403Cytotoxicity in human A549 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID399914Cytotoxicity against human HL60 cells2004Journal of natural products, Feb, Volume: 67, Issue:2
Biologically active compounds from Aphyllophorales (polypore) fungi.
AID338910Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 10 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID711416Cytotoxicity against human HL60 cells2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Lanostanoids from fungi: a group of potential anticancer compounds.
AID591402Cytotoxicity in human HL60 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID338908Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells assessed as EA activation at 500 molar ratio after 48 hrs by indirect immunofluorescence method relative to TPA2002Journal of natural products, Apr, Volume: 65, Issue:4
Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos.
AID591405Cytotoxicity in human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
AID591404Cytotoxicity in human OVCAR3 cells assessed as cell viability after 48 hrs by MTT assay2011Journal of natural products, Feb-25, Volume: 74, Issue:2
Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (60.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (40.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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