Compounds > methyl lucidenate f
Page last updated: 2024-11-13

methyl lucidenate f

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methyl lucidenate F: from the dried fruiting bodies of Ganoderma lucidum (polyporaceae); structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID21633085
CHEMBL ID462240
CHEBI ID175684
MeSH IDM0401989

Synonyms (7)

Synonym
methyl (4r)-4-[(5r,10s,13r,14r,17r)-4,4,10,13,14-pentamethyl-3,7,11,15-tetraoxo-2,5,6,12,16,17-hexahydro-1h-cyclopenta[a]phenanthren-17-yl]pentanoate
CHEBI:175684
methyl lucidenate f
CHEMBL462240
methyl (5alpha)-4,4,14-trimethyl-3,7,11,15-tetraoxochol-8-en-24-oate
DTXSID201171769
98665-10-2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID355403Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA induction at 500 molar ratio relative to 12-O-tetradecanoylphorbol-13-acetate by immunofluorescence technique2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
AID355404Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA induction at 100 molar ratio relative to 12-O-tetradecanoylphorbol-13-acetate by immunofluorescence technique2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
AID1239169Inhibition of p-glycoprotein in human adriamycin-resistant MCF7 cells assessed as increase of adriamycin accumulation at 20 uM after 1 hr by by LC-MS/MS analysis relative to control2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Inhibitory Effects of Highly Oxygenated Lanostane Derivatives from the Fungus Ganoderma lucidum on P-Glycoprotein and α-Glucosidase.
AID502693Cytotoxicity against mouse 3T3L1 cells assessed as cell viability at up to 40 ug/ml2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Lanostane triterpenes from Ganoderma lucidum suppress the adipogenesis in 3T3-L1 cells through down-regulation of SREBP-1c.
AID464414Cytotoxicity against mouse 3T3L1 cells at 40 ug/ml after 2 days by MTT assay2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells.
AID355401Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio by trypan blue staining method2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
AID355406Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed per 32 pmol TPA by immunofluorescence technique2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
AID355405Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA induction at 10 molar ratio relative to 12-O-tetradecanoylphorbol-13-acetate by immunofluorescence technique2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
AID464416Inhibition of adipocytes differentiation in mouse 3T3L1 cells assessed as lipid accumulation at 40 ug/ml after 8 days by Oil red O staining relative to control2010Journal of natural products, Feb-26, Volume: 73, Issue:2
Lanostane triterpenes from the fruiting bodies of Ganoderma lucidum and their inhibitory effects on adipocyte differentiation in 3T3-L1 Cells.
AID355402Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as EA induction at 1000 molar ratio relative to 12-O-tetradecanoylphorbol-13-acetate by immunofluorescence technique2003Journal of natural products, Dec, Volume: 66, Issue:12
Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		2.1110aromatic ether;
nitrile;
polyether;
tertiary amino compound
acarbose
[no description available]		2.1110amino cyclitol;
glycoside
ganoderic acid a
[no description available]		2.4620triterpenoid
beta carotene
beta Carotene: A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).. provitamin A : A provitamin that can be converted into vitamin A by enzymes from animal tissues.		2.0110carotenoid beta-end derivative;
cyclic carotene		antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A
lucidenic acid a
lucidenic acid A: isolated from fruiting bodies of Ganoderma lucidum; structure in first source		2.0110triterpenoid
lucidenic acid n
lucidenic acid N: from the dried fruiting bodies of Ganoderma lucidum (polyporaceae); structure in first source. lucidenic acid N : A tetracyclic triterpenoid that is 25,26,27-trinorlanost-8-en-24-oic acid substituted by hydroxy groups at positions 3 and 7 and oxo groups at positions 11 and 15 respectively (the 3beta,5alpha,7beta stereoisomer). Isolated from the fruiting bodies of Ganoderma lucidum, it exhibits cytotoxicity against tumour cells.		2.7330cyclic terpene ketone;
dioxo monocarboxylic acid;
secondary alcohol;
tetracyclic triterpenoid		antineoplastic agent;
EC 3.1.1.8 (cholinesterase) inhibitor;
metabolite
ganoderic acid f
ganoderic acid F: isolated from Ganoderma lucidum; structure in first source		2.0110triterpenoid
ConditionIndicatedRelationship StrengthStudiesTrials
B-Cell Lymphoma
[description not available]		02.0110
Lymphoma, B-Cell
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.		02.0110