Compounds > ganoderic acid d
Page last updated: 2024-11-13

ganoderic acid d

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ganoderic acid D: isolated from Ganoderma lucidum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID102004379
MeSH IDM0521454

Synonyms (5)

Synonym
ganoderic acid d
AC-34453
ganoderic-acid-d
108340-60-9
AKOS037515103

Research Excerpts

Overview

Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid.

ExcerptReferenceRelevance
"Ganoderic acid D (GAD) is a highly oxygenated tetracyclic triterpenoid. "( Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D.
Li, L; Liu, Z; Xue, B, 2018)		2.33

Pharmacokinetics

ExcerptReferenceRelevance
" In the meantime, the Cmax increased from 107."( Pharmacokinetics of ganoderic acid D and its main metabolite by liquid chromatography-tandem mass spectrometry.
Cheng, CR; Ding, J; Guan, SH; Guo, DA; Pang, XY; Wang, Y; Wu, XH; Yang, M; Yang, Y, 2013)		0.71

Bioavailability

ExcerptReferenceRelevance
" The data showed that the absolute bioavailability increased from 22% to 70% after the GD suspension was changed to GD loaded solid lipid nanoparticles."( Pharmacokinetics of ganoderic acid D and its main metabolite by liquid chromatography-tandem mass spectrometry.
Cheng, CR; Ding, J; Guan, SH; Guo, DA; Pang, XY; Wang, Y; Wu, XH; Yang, M; Yang, Y, 2013)		0.71
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.05

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.05 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.72 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.05)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lanosterol
[no description available]		2.061014alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid		bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
ganodermic acid s
ganodermic acid S: RN given refers to (3beta,15alpha,24E)-isomer		2.0510triterpenoid
ganoderic acid h
ganoderic acid H: isolated from Ganoderma lucidum; structure in first source		2.0610
ganoderic acid a
ganoderic acid A: isolated from Ganoderma lucidum; structure in first source		2.0610
ganoderic acid b
ganoderic acid B: from Ganoderma lucidum in different places and stages by means of HPLC. The results show that contents of ganoderic acid B from different cultured places have differnces, different stages have effect on the amount too.		2.0610
ConditionIndicatedRelationship StrengthStudiesTrials
Esophageal Squamous Cell Carcinoma
A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.		02.2510
Cancer of Esophagus
[description not available]		02.2510
Esophageal Neoplasms
Tumors or cancer of the ESOPHAGUS.		02.2510
Cancer of Colon
[description not available]		02.1710
Colonic Neoplasms
Tumors or cancer of the COLON.		02.1710
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810