methyl phenylglycine profile

Methyl phenylglycine, also known as N-methylphenylglycine, is a synthetic amino acid that is a precursor to the stimulant drug phenethylamine. It is not found naturally in the body and is synthesized through a process involving the reaction of phenylglycine with formaldehyde. Methyl phenylglycine has been shown to have stimulant effects, including increased alertness, energy, and focus. These effects are believed to be due to its ability to increase the release of dopamine in the brain. Research has investigated its potential as a treatment for attention-deficit/hyperactivity disorder (ADHD) and other conditions involving dopamine deficiency. However, it is important to note that methyl phenylglycine has not been approved for medical use and its safety and efficacy are still under investigation.'

methyl phenylglycine: RN given refers to parent cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	117324
CHEMBL ID	4634947
SCHEMBL ID	283419
MeSH ID	M0103608

Synonym
ENAMINE_005656
CBDIVE_003088
IDI1_007891
STK256724
methyl amino(phenyl)acetate
methyl phenylglycine
HMS1410B02
AKOS005064352
methyl 2-amino-2-phenylacetate
mfcd01026128
benzeneacetic acid, alpha-amino-, methyl ester
unii-1hxr2nau0z
1hxr2nau0z ,
d-alpha-phenylglycine methyl ester
26682-99-5
methyl phenylglycinate, (+/-)-
methyl phenylglycinate, dl-
methyl phenylglycinate
methyl dl-.alpha.-phenylglycinate
.alpha.-phenylglycine methyl ester [mi]
methyl dl-phenylglycinate
benzeneacetic acid, .alpha.-amino-, methyl ester
methyl amino(phenyl)acetate hydrochloride
SCHEMBL283419
dl-.alpha.-phenylglycine, methyl ester
glycine, 2-phenyl-, methyl ester
alpha-phenylglycine methyl ester
EN300-61109
(s)-a-amino-benzeneacetic acid methyl ester
dl-methyl phenylglycinate
Q27252441
AB89440
CS-0150922
HY-W098280
CHEMBL4634947
methyl2-amino-2-phenylacetate

Assay ID	Title	Year	Journal	Article
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1651246	Drug metabolism in THF assessed as release of hydrogen disulphide at 10 mM in presence of S-acetylsulfanylethanethioate by DSP-3 probe based fluorescence assay	2020	Bioorganic & medicinal chemistry letters, 02-15, Volume: 30, Issue:4	Diacyl disulfides as the precursors for hydrogen persulfide (H
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (3.85)	18.7374
1990's	3 (11.54)	18.2507
2000's	14 (53.85)	29.6817
2010's	4 (15.38)	24.3611
2020's	4 (15.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
ethylene glycol Ethylene Glycol: A colorless, odorless, viscous dihydroxy alcohol. It has a sweet taste, but is poisonous if ingested. Ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the United States. It is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.. ethanediol : Any diol that is ethane or substituted ethane carrying two hydroxy groups.. ethylene glycol : A 1,2-glycol compound produced via reaction of ethylene oxide with water.	2.15	1	ethanediol; glycol	metabolite; mouse metabolite; solvent; toxin
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	2.42	2	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
benzaldehyde [no description available]	2.01	1	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
carbamates [no description available]	2.01	1	amino-acid anion
carbamic acid carbamic acid : A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised.	2.01	1	carbon oxoacid; one-carbon compound; organonitrogen compound	Escherichia coli metabolite
trimethylenediamine trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.	2.25	1	alkane-alpha,omega-diamine	human metabolite; mouse metabolite; reagent
glycine [no description available]	4.55	24	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
hydrogen Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.	2.01	1	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
pyridoxal [no description available]	2.01	1	hydroxymethylpyridine; methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.93	4	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.25	1	alkane-alpha,omega-diamine	GABA agonist
2-phenylglycine 2-phenylglycine: RN given refers to cpd without isomeric designation; structure. alpha-phenylglycine : An amino acid with a structure in which a phenyl ring is bonded to the alpha-carbon of glycine.	2	1	non-proteinogenic alpha-amino acid	human metabolite
aniline [no description available]	2.25	1	anilines; primary arylamine
dimethylformamide Dimethylformamide: A formamide in which the amino hydrogens are replaced by methyl groups.. N,N-dimethylformamide : A member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups.	2.01	1	formamides; volatile organic compound	geroprotector; hepatotoxic agent; polar aprotic solvent
ampicillin Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.	2.41	2	beta-lactam antibiotic; penicillin allergen; penicillin	antibacterial drug
penicillanic acid Penicillanic Acid: A building block of penicillin, devoid of significant antibacterial activity. (From Merck Index, 11th ed). penicillanic acid : A penam that consists of 3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane bearing a carboxy group at position 2 and having (2S,5R)-configuration.	2.7	3	penicillanic acids
propylene glycol methyl ether propylene glycol methyl ether: RN given refers to unspecified methoxypropanol; structure	2.41	1
n-butylamine n-butylamine: RN given refers to parent cpd. butan-1-amine : A primary aliphatic amine that is butane substituted by an amino group at position 1.	2.25	1	primary aliphatic amine
aminopenicillanic acid aminopenicillanic acid: RN given refers to parent cpd; structure. 6-aminopenicillanic acid : A penicillanic acid compound having a (6R)-amino substituent. The active nucleus common to all penicillins, it may be substituted at the 6-amino position to form the semisynthetic penicillins, resulting in a variety of antibacterial and pharmacologic characteristics.	2.7	3	amino acid zwitterion; penicillanic acids	allergen
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.05	1	metal allergen; nickel group element atom; platinum group metal atom
galactose aldohexose : A hexose with a (potential) aldehyde group at one end.	2.01	1
cephalexin Cephalexin: A semisynthetic cephalosporin antibiotic with antimicrobial activity similar to that of CEPHALORIDINE or CEPHALOTHIN, but somewhat less potent. It is effective against both gram-positive and gram-negative organisms.. cephalexin : A semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively. It is effective against both Gram-negative and Gram-positive organisms, and is used for treatment of infections of the skin, respiratory tract and urinary tract.	3.11	5	beta-lactam antibiotic allergen; cephalosporin; semisynthetic derivative	antibacterial drug
7-aminodesacetoxycephalosporanic acid 7-amino-3-methyl-delta(3)-cephem-4-carboxylic acid: key intermediate in preparation of several semisynthetic beta-lactam antibiotics; structure. 7beta-aminodeacetoxycephalosporanic acid : A cephem monocarboxylic acid derivative having a structure based on cephalosporanic acid, deacetoxylated and carrying a 7beta-amino group.	3.13	5	cephalosporin; monocarboxylic acid
cefaclor anhydrous Cefaclor: Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.. cefaclor : A cephalosporin bearing chloro and (R)-2-amino-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.	2.01	1	cephalosporin	antibacterial drug; drug allergen
cephalosporin c cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.	3.29	6	cephalosporin	fungal metabolite
mosher's acid Mosher's acid: structure in first source	2.01	1
beta-lactams 2-azetidinone: structure in first source. azetidin-2-one : An unsubstituted beta-lactam compound.. beta-lactam : A lactam in which the amide bond is contained within a four-membered ring, which includes the amide nitrogen and the carbonyl carbon.	2.02	1	beta-lactam antibiotic allergen; beta-lactam
fenton's reagent Fenton's reagent: used for oxidizing sugars & alcohols	2.45	2
lanosterol [no description available]	2.31	1	14alpha-methyl steroid; 3beta-sterol; tetracyclic triterpenoid	bacterial metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
oxazolone Oxazolone: Immunologic adjuvant and sensitizing agent.	7.02	1
1-butyl-3-methylimidazolium tetrafluoroborate [no description available]	2.03	1
phenylacetyl disulfide phenylacetyl disulfide: structure in first source	2.25	1
pectenotoxin 6 pectenotoxin 6: isolated from scallops (Patinopecten yessoensis); structure in first source	1.99	1	polycyclic ether; spiroketal	marine metabolite
sorbitan monooleate [no description available]	2.01	1	fatty acid ester
ganoderic acid a ganoderic acid A: isolated from Ganoderma lucidum; structure in first source	2.31	1

Condition	Relationship Strength	Studies
Encephalitis, Polio [description not available]	2.06	1
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	2.06	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.03	1

methyl phenylglycine

Description

Cross-References

Synonyms (36)

Bioassays (2)

Research

Studies (26)

Market Indicators

Research Demand Index: 24.96

Study Types