Page last updated: 2024-11-13
3,7-dioxolanosta-8,24-dien-26-oic acid
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
3,7-dioxolanosta-8,24-dien-26-oic acid: isolated from the mushroom Ganoderma lucidum [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 46888220 |
CHEMBL ID | 1099224 |
MeSH ID | M0588848 |
PubMed CID | 72787537 |
MeSH ID | M0588848 |
Synonyms (9)
Synonym |
---|
173075-45-1 |
CHEMBL1099224 |
ganoderic acid dm |
bdbm50104745 |
AKOS032948636 |
(z,6r)-2-methyl-6-[(5r,10s,13r,14r,17r)-4,4,10,13,14-pentamethyl-3,7-dioxo-2,5,6,11,12,15,16,17-octahydro-1h-cyclopenta[a]phenanthren-17-yl]hept-2-enoic acid |
3,7-dioxolanosta-8,24-dien-26-oic acid |
BCP16405 |
gaderic acid dm |
Research Excerpts
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (23)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID353555 | Inhibition of 5-alpha-reductase in rat liver microsome assessed as conversion of [14C] testosterone to [14C] dihydrotestosterone | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1235935 | Cytotoxicity against human PC3 cells by MTT method | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID353564 | Cytotoxicity against mouse RAW264 cells assessed as viable cells at 25 uM after 3 days by WST1 assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1235933 | Inhibition of maltase in rat intestinal mucosa pre-incubated for 40 mins using maltose substrate | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID1551897 | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by WST-1 assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. |
AID353557 | Growth inhibition against testosterone-induced human LNCAP cell proliferation assessed as decrease in cell viability after 3 dayssby NR assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1235931 | Inhibition of alpha-glucosidase in rat intestinal mucosa pre-incubated for 40 mins using p-nitrophenyl-alpha-D-glucopyranoside substrate | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID1235929 | Inhibition of pig liver microsomes HMG-CoA reductase incubated for 5 mins in using HMG-CoA and NADPH by colorimetric method | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID1235932 | Inhibition of sucrase in rat intestinal mucosa pre-incubated for 40 mins using sucrose substrate | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID1551899 | Inhibition of calcitriol-induced formation of Sprague-Dawley rat osteoclasts by WST-1 assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. |
AID353562 | Inhibition of osteoclastogenesis in RANKL-stimulated mouse RAW264 cells at 25 uM after 3 days by TRAP assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1235934 | Cytotoxicity against human K562 cells by MTT method | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID711425 | Inhibition of rat microsomal 5-alpha reductase assessed as inhibition of conversion of [4-14C]testosterone to [4-14C] dihydrotestosterone after 10 mins | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Lanostanoids from fungi: a group of potential anticancer compounds. |
AID353554 | Inhibition of DHT binding to human recombinant androgen receptor ligand binding domain at 15 uM by fluorescence polarization | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1235930 | Inhibition of Baker's yeast alpha-glucosidase | 2015 | Journal of natural products, Aug-28, Volume: 78, Issue:8 | Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase. |
AID353559 | Antiproliferative activity against human PC3 cells at 12.5 to 50 uM after 3 days by NR assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID1551898 | Inhibition of RANKL/tumour necrosis factor alpha-induced formation of osteoclasts (unknown origin) by tartrate-resistant acid phosphatase staining based assay | 2019 | European journal of medicinal chemistry, Jul-15, Volume: 174 | Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. |
AID353563 | Cytotoxicity against mouse RAW264 cells assessed as cell number at 12.5 uM after 3 days by WST1 assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID353556 | Growth inhibition of human LNCAP cells assessed as decrease in cell viability after 3 days by NR assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID353561 | Inhibition of osteoclastogenesis in RANKL-stimulated mouse RAW264 cells at 12.5 uM after 3 days by TRAP assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
AID479066 | Antiplasmodial activity against Plasmodium falciparum at 20 uM | 2010 | Journal of natural products, May-28, Volume: 73, Issue:5 | Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. |
AID711441 | Cytotoxicity against human HeLa cells | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Lanostanoids from fungi: a group of potential anticancer compounds. |
AID353558 | Growth inhibition against dihydrotestosterone-induced human LNCAP cell proliferation assessed as decrease in cell viability after 3 dayssby NR assay | 2009 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 19, Issue:8 | Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (11)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (9.09) | 18.2507 |
2000's | 1 (9.09) | 29.6817 |
2010's | 7 (63.64) | 24.3611 |
2020's | 2 (18.18) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.84
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.84) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (40.00%) | 6.00% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Observational | 0 (0.00%) | 0.25% |
Other | 3 (60.00%) | 84.16% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |