Page last updated: 2024-12-06

eburicoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Eburicoic acid is a triterpenoid compound isolated from the fungus _Polyporus officinalis_. It exhibits a range of biological activities, including anti-inflammatory, anti-cancer, and anti-viral properties. Research has focused on understanding its mechanisms of action, particularly its ability to inhibit the production of inflammatory mediators and its potential as a therapeutic agent for various diseases. The compound's unique structure and biological activities have made it a target of interest for synthetic chemists, who are investigating its potential for development into new drugs.'
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eburicoic acid: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID73402
CHEMBL ID179188
SCHEMBL ID18195824
MeSH IDM0046082

Synonyms (17)

Synonym
nsc 41969
unii-fe37kg6a7q
3beta-hydroxy-24-methylene-8-lanostene-21-oic acid
fe37kg6a7q ,
560-66-7
nsc-41969
eburicoic acid
CHEMBL179188
SCHEMBL18195824
(2r)-2-[(3s,5s,10s,13r,14r,17r)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3 ,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-17-yl]-6-m ethyl-5-methylidene-heptanoic acid
(r)-2-((3s,5r,10s,13r,14r,17r)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl)-6-methyl-5-methyleneheptanoic acid
MS-28713
HY-122951
CS-0090665
lanost-8-en-21-oic acid, 3-hydroxy-24-methylene-, (3beta)-
eburcoic acid
AKOS040760373

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID333724Induction apoptosis in human HL60 cells assessed as intranucleosomal DNA fragmentation at 30 uM after 16 hrs by electrophoresis2004Journal of natural products, Dec, Volume: 67, Issue:12
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
AID1546669Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID247402Growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program2005Journal of medicinal chemistry, Mar-10, Volume: 48, Issue:5
CHMIS-C: a comprehensive herbal medicine information system for cancer.
AID288570Cell viability of Raji cells2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID333722Induction apoptosis in human HL60 cells assessed as appearance of apoptotic bodies at 10 uM after 8 hrs by fluorescence microscopy2004Journal of natural products, Dec, Volume: 67, Issue:12
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
AID1546666Cytotoxicity against human U251 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID1546667Cytotoxicity against human MCF7 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID288569Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 10 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288568Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 100 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID711416Cytotoxicity against human HL60 cells2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Lanostanoids from fungi: a group of potential anticancer compounds.
AID333721Induction apoptosis in human HL60 cells assessed as condensation of chromatin at 10 uM after 8 hrs by fluorescence microscopy2004Journal of natural products, Dec, Volume: 67, Issue:12
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
AID288567Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 500 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID333720Cytotoxicity against human HL60 cells after 96 hrs by MTT assay2004Journal of natural products, Dec, Volume: 67, Issue:12
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
AID1064288Cytotoxicity against human HS68 cells at 25 to 200 uM after 48 hrs by SRB assay2014Journal of natural products, Jan-24, Volume: 77, Issue:1
Antcamphins A-L, ergostanoids from Antrodia camphorata.
AID333728Induction apoptosis in human HL60 cells assessed as caspase 3 activity after 6 hrs2004Journal of natural products, Dec, Volume: 67, Issue:12
Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells.
AID288566Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 1000 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID1546668Cytotoxicity against human SW480 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (18.75)18.7374
1990's0 (0.00)18.2507
2000's4 (25.00)29.6817
2010's8 (50.00)24.3611
2020's1 (6.25)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.09 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.88%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (94.12%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]