ganoderic acid T: down-regulates expression of both MMP-2 and MMP-9; isolated from Ganoderma lucidum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 21637704 |
| CHEMBL ID | 2205006 |
| SCHEMBL ID | 5808320 |
| MeSH ID | M0547864 |
| Synonym |
|---|
| CHEMBL2205006 |
| ganoderic acid t |
| SCHEMBL5808320 |
| HY-N11591 |
| CS-0650591 |
| (e,5s,6s)-5-acetyloxy-6-[(3r,5r,10s,13r,14r,15s,17r)-3,15-diacetyloxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylhept-2-enoic acid |
Ganoderic acid T (GA-T) is an important triterpene of Ganoderma lucidum. It is utilized to treat viral infections.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Ganoderic acid T (GA-T) is an important triterpene of Ganoderma lucidum, which is utilized to treat viral infections. " | ( Transcriptome profiling and bioinformatic analysis of the effect of ganoderic acid T prevents Sendai virus infection. Chen, N; Jiang, L; Meng, J; Shi, P; Wan, G; Xia, S; Zhai, DD; Zhang, W, 2023) | 2.59 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID711443 | Antitumor activity against mouse LLC cells allografted in C57B/6 mouse assessed as tumor growth inhibition at 28 mg/kg relative to control | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Lanostanoids from fungi: a group of potential anticancer compounds. |
| AID1289457 | Antitubercular activity against Mycobacterium tuberculosis H37Ra infected in African green monkey Vero cells measured daily for 8 days by green fluorescent protein microplate assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642. |
| AID711442 | Antitumor activity against mouse LLC cells allografted in C57B/6 mouse assessed as inhibition of tumor metastasis at 28 mg/kg relative to control | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Lanostanoids from fungi: a group of potential anticancer compounds. |
| AID1289458 | Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay | 2016 | Journal of natural products, Jan-22, Volume: 79, Issue:1 | Antitubercular Lanostane Triterpenes from Cultures of the Basidiomycete Ganoderma sp. BCC 16642. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (18.24) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (10.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (90.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||