Compounds > 2-keto-3-deoxy-6-phosphogluconate
Page last updated: 2024-11-10

2-keto-3-deoxy-6-phosphogluconate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-keto-3-deoxy-6-phosphogluconate: structure given in first source; an intermediate in glucose metabolism [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

2-dehydro-3-deoxy-6-phospho-D-gluconic acid : The 5-phospho derivative of 2-dehydro-D-gluconic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3080745
CHEMBL ID1162150
CHEBI ID15925
SCHEMBL ID666269
MeSH IDM0216678

Synonyms (21)

Synonym
d-erthro-hexulosonic acid, 3-deoxy-, 6-(dihydrogen phosphate)
2-dehydro-3-deoxy-6-phospho-d-gluconic acid
CHEBI:15925 ,
3-deoxy-6-o-phosphono-d-erythro-hex-2-ulosonic acid
kdpg intermediate
6-phospho-2-dehydro-3-deoxy-d-gluconate
2-keto-3-deoxy-6-phosphogluconate
C04442
3-deoxy-d-erythro-hex-2-ulosonic acid 6-phosphate
2-dehydro-3-deoxy-d-gluconate 6-phosphate
27244-54-8
2-dehydro-3-deoxy-6-phospho-d-gluconate
(4s,5r)-4,5-dihydroxy-2-oxo-6-phosphonooxyhexanoic acid
2-keto-3-deoxy-6-phosphogluconic acid
CHEMBL1162150
SCHEMBL666269
(4s,5r)-4,5-dihydroxy-2-oxo-6-(phosphonooxy)hexanoic acid
2-dehydro-3-deoxy-d-gluconate-6-phosphate
Q27098301
2-keto 3 deoxy 6 phospho gluconate
PD193342

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" The concentration of compounds causing 50% inhibition of enzyme activity was determined from dose-response curves."( The Entner-Doudoroff pathway in Helicobacter pylori.
Burns, BP; Hazell, SL; Mendz, GL, 1994)		0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
ketoaldonic acid phosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (5)

PathwayProteinsCompounds
Hexuronide and Hexuronate Degradation1520
Ketogluconate Metabolism1017
superpathway of glycolysis and Entner-Doudoroff023
superpathway of gluconate degradation48
D-galacturonate degradation44

Protein Targets (2)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
Entner-Doudoroff pathway through 6-phosphogluconateKHG/KDPG aldolaseEscherichia coli K-12
D-galactonate catabolic process2-dehydro-3-deoxy-6-phosphogalactonate aldolaseEscherichia coli K-12
D-galactonate catabolic process2-dehydro-3-deoxy-6-phosphogalactonate aldolaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
2-dehydro-3-deoxy-phosphogluconate aldolase activityKHG/KDPG aldolaseEscherichia coli K-12
4-hydroxy-2-oxoglutarate aldolase activityKHG/KDPG aldolaseEscherichia coli K-12
oxaloacetate decarboxylase activityKHG/KDPG aldolaseEscherichia coli K-12
lyase activityKHG/KDPG aldolaseEscherichia coli K-12
oxo-acid-lyase activityKHG/KDPG aldolaseEscherichia coli K-12
identical protein bindingKHG/KDPG aldolaseEscherichia coli K-12
(4S)-4-hydroxy-2-oxoglutarate aldolase activityKHG/KDPG aldolaseEscherichia coli K-12
2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity2-dehydro-3-deoxy-6-phosphogalactonate aldolaseEscherichia coli K-12
lyase activity2-dehydro-3-deoxy-6-phosphogalactonate aldolaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
cytoplasmKHG/KDPG aldolaseEscherichia coli K-12
cytosolKHG/KDPG aldolaseEscherichia coli K-12
membraneKHG/KDPG aldolaseEscherichia coli K-12
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID318278Activity of Escherichia coli KDPGal aldolase V154T mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318273Activity of Escherichia coli KDPG aldolase T161A mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318275Ratio of kcat to Km of Escherichia coli KDPG aldolase T161V mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318271Activity of Escherichia coli KDPG aldolase2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318272Activity of Escherichia coli KDPG aldolase T161V mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318274Ratio of kcat to Km of Escherichia coli KDPG aldolase2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318279Activity of Escherichia coli KDPGal aldolase V154A mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318280Ratio of kcat to Km for Escherichia coli KDPGal aldolase2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318277Activity of Escherichia coli KDPGal aldolase2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318282Ratio of kcat to Km for Escherichia coli KDPGal aldolase V154A mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318281Ratio of kcat to Km for Escherichia coli KDPGal aldolase V154T mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
AID318276Ratio of kcat to Km of Escherichia coli KDPG aldolase T161A mutant2008Bioorganic & medicinal chemistry, Jan-15, Volume: 16, Issue:2
Characterization and crystal structure of Escherichia coli KDPGal aldolase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's4 (21.05)18.2507
2000's8 (42.11)29.6817
2010's6 (31.58)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.67 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index4.99 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other19 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dihydroxyacetone phosphate
Dihydroxyacetone Phosphate: An important intermediate in lipid biosynthesis and in glycolysis.. dihydroxyacetone phosphate : A member of the class of glycerone phosphates that consists of glycerone bearing a single phospho substituent.		210glycerone phosphates;
primary alpha-hydroxy ketone		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glyoxylic acid
glyoxylic acid: RN given refers to parent cpd. glyoxylic acid : A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the alpha carbon atom.		2.15102-oxo monocarboxylic acid;
aldehydic acid		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
phenylacetic acid
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.		7.0510benzenes;
monocarboxylic acid;
phenylacetic acids		allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		2.43202-oxo monocarboxylic acidcofactor;
fundamental metabolite
gluconic acid
gluconic acid: zinc gluconate has anti-inflammatory activity; RN given refers to (D)-isomer; all RRs refers to (D)-isomer unless otherwise noted. ketogluconic acid : A gluconic acid that contains a ketonic carbonyl group.. D-gluconic acid : A gluconic acid having D-configuration.		2.940gluconic acidchelator;
Penicillium metabolite
copper gluconate
Gluconates: Derivatives of gluconic acid (the structural formula HOCH2(CHOH)4COOH), including its salts and esters.		4.26180organic molecular entity
6-phosphogluconic acid
gluconic acid-6-phosphate: structure. 6-phospho-D-gluconate : A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of 6-phospho-D-gluconic acid.. 6-phospho-D-gluconic acid : A gluconic acid phosphate having the phosphate group at the 6-position. It is an intermediate in the pentose phosphate pathway.		3.0750gluconic acid phosphatefundamental metabolite
glucuronic acid
Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.. D-glucuronic acid : The D-enantiomer of glucuronic acid.. D-glucopyranuronic acid : A D-glucuronic acid in cyclic pyranose form.		2.5320D-glucuronic acidalgal metabolite
2-oxo-3-deoxygalactonic acid
2-dehydro-3-deoxy-D-galactonic acid : The 2-dehydro-3-deoxy derivative of D-galactonic acid.		2.0710hexonic acid;
ketoaldonic acid		Escherichia coli metabolite
pectins
Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.. alpha-D-galacturonic acid : The alpha-anomer of D-galacturonic acid.		210D-galactopyranuronic acid
nadp
[no description available]		2.3920
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		1.9810organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
mersacidin
mersacidin: a globular type B lantibiotic; peptide isolated form a Bacillus species. mersacidin : A type-B lantibiotic containing 3-methyllanthionine and S-(2-aminovinyl)-3-methylcysteine residues and four intra-chain thioether bridges. It is obtained from Bacillus sp. HIL Y-85,54728 and is active in vivo against methicillin-resistant Staphylococcus aureus (MRSA).		2.0710
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9810