Page last updated: 2024-12-11
enviradene
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6435398 |
| CHEMBL ID | 290507 |
| SCHEMBL ID | 146323 |
| MeSH ID | M0112434 |
Synonyms (23)
| Synonym |
|---|
| enviradene (usan) |
| D04010 |
| 80883-55-2 |
| enviradene |
| CHEMBL290507 |
| ly-127123 |
| ly 127123 |
| 6-[(e)-1-phenylprop-1-enyl]-1-propan-2-ylsulfonylbenzimidazol-2-amine |
| enviradeno [spanish] |
| (e)-2-amino-1-(isopropylsulfonyl)-6-(1-phenylpropenyl)benzimidazole |
| 1h-benzimidazol-2-amine, 1-((1-methylethyl)sulfonyl)-6-(1-phenyl-1-propenyl)-, (e)- |
| enviradeno |
| enviradene [usan:inn] |
| 9q79a81839 , |
| enviradenum [latin] |
| enviradenum |
| unii-9q79a81839 |
| (e)-1-((1-methylethyl)sulfonyl)-6-(1-phenyl-1-propenyl)-1h-benzimidazol-2-amine |
| enviradene [inn] |
| enviradene [usan] |
| SCHEMBL146323 |
| DTXSID00230769 |
| Q27272893 |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " The bioavailability of the drug in dogs was found to be increased by the concomitant administration of food." | ( Liquid chromatographic analysis of enviradene, a new antiviral agent, in plasma and its application in bioavailability studies in the dog. Bopp, RJ; Miner, DJ; Morris, RM; Quay, JF; Stucky, JF, 1985) | 0.55 |
| "In an effort to find an orally bioavailable antiviral for the treatment of rhino/enteroviral infections, a series of vinylacetylene benzimidazoles (11a-o, 12, and 18a) was made." | ( Antirhino/enteroviral vinylacetylene benzimidazoles: a study of their activity and oral plasma levels in mice. Lee, CC; McKinney, E; Miller, SC; Sattelberg, TR; Spitzer, WA; Tang, JC; Tebbe, MJ; Victor, F, 1997) | 0.3 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID89954 | In vitro hepatic microsomal metabolism in human | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID187080 | In vitro hepatic microsomal metabolism in rat. | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID59918 | In vitro hepatic microsomal metabolism in dog | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID134630 | In vitro Hepatic microsomal metabolism in mouse | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID126648 | In vitro hepatic microsomal metabolism in monkey | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID199400 | In vitro antiviral activity in rhesus monkey by Poliovirus (type1,Mahoney) plaque reduction assay | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID199407 | In vitro plasma levels in Rhesus monkey was determined at a dose of 8 mg/kg administered orally | 1997 | Journal of medicinal chemistry, May-09, Volume: 40, Issue:10 | Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. |
| AID1656997 | Antiviral activity against Poliovirus type 1 Mahoney infected in African green monkey BSC1 cells by crystal violet staining based plaque reduction assay | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11 | Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID1656998 | Cmax in rhesus monkey at 8 mg/kg, po | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11 | Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID14287 | Oral plasma concentration in mice at 100 mg/kg dosage within 4-hr time frame. | 1997 | Journal of medicinal chemistry, Nov-21, Volume: 40, Issue:24 | Antirhino/enteroviral vinylacetylene benzimidazoles: a study of their activity and oral plasma levels in mice. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.47
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.47) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||