| Assay ID | Title | Year | Journal | Article |
|---|
| AID1540202 | Inhibition of human MAOA | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
| AID1545349 | Inhibition of human plasma butyrylcholinesterase by Ellman's method | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID635883 | Time-dependent inhibition of rat liver mitochondrial MAO-B using phenylethylamine at 45 nM | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635885 | Irreversible inhibition of rat liver mitochondrial MAO-B using phenylethylamine as substrate assessed as substrate consumption at 100 nM measured up to 420 mins | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1545350 | Displacement of [3H]-N-alpha-methylhistamine from human H3R expressed in HEK293 cell membranes incubated for 90 mins by liquid scintillation counting method | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID635918 | Irreversible inhibition of rat liver mitochondrial MAO-A using 5-hydroxytriptamine as substrate assessed as substrate consumption at 10 nM preincubated for 30 mins measured up to 420 mins | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1545348 | Inhibition of human acetylcholinesterase expressed in HEK 293 cells using acetylthiocholine iodide as substrate by Ellman's method | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID635878 | Inhibition of rat liver mitochondrial MAO-B using [14C]-phenylethylamine after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635880 | Irreversible inhibition of rat liver mitochondrial MAO-A using 5-hydroxytryptamine as substrate at 6 nM preincubated for 30 mins measured after three consecutive washes with buffer | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1555512 | Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation counting analysis | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID635882 | Reversible inhibition of rat liver mitochondrial MAO-B using phenylethylamine assessed as recovered enzyme activity at 45 nM preincubated for 30 mins measured after three consecutive washes with buffer | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1076175 | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 25 mins by Ellman's method | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1506096 | Cognitive enhancing effect in amyloid beta (1 to 42)-induced dementia Balb/c mouse model assessed as protection against spatial memory impairment by measuring latency to find food on fourth day of test at 1 to 10 mg/kg, po qd via gavage for 17 days starti | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID635874 | Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1076174 | Selectivity ratio of IC50 for equine serum BuChE to IC50 for electric eel AChE | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1195741 | Inhibition of human MAO-B expressed in baculovirus infected BTI insect cells preincubated for 15 mins | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID1195746 | Selectivity ratio of IC50 for recombinant human AChE expressed in HEK293 cells to IC50 for recombinant human BuChE expressed in HEK293 cells | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID635884 | Irreversible inhibition of rat liver mitochondrial MAO-A using 5-hydroxytriptamine as substrate assessed as substrate consumption at 10 nM measured up to 420 mins | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1195745 | Selectivity ratio of IC50 for human MAO-A expressed in baculovirus infected BTI insect cells to IC50 for human MAO-B expressed in baculovirus infected BTI insect cells | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID1506085 | Displacement of (+)-[3H]pentazocine from human sigma1 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting method | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1506099 | Cognitive enhancing effect in amyloid beta (1 to 42)-induced dementia Balb/c mouse model assessed as protection against spatial memory impairment by measuring reduction in total errors to find food on third and fourth days of test at 1 to 10 mg/kg, po qd | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID635876 | Mixed type inhibition of Electrophorus electricus AchE using acetylthiocholine as substrate by Line-Weaver Burk plot analysis | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1656490 | Inhibition of human AChE | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| AID1506088 | Displacement of (-)-[3H]vesamicol from rat VAChT expressed in rat PC12 cell membranes after 60 mins by liquid scintillation counting method | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1195742 | Inhibition of recombinant human AChE expressed in HEK293 cells preincubated for 15 mins | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID1506089 | Selectivity ratio of Ki for sigma2 receptor in rat liver membranes to Ki for human sigma1 receptor expressed in HEK293 cell membranes | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1656491 | Inhibition of human BuChE | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| AID1540200 | Inhibition of human AChE | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
| AID1555508 | Inhibition of BACE-1 (unknown origin) | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID635919 | Reversible inhibition of rat liver mitochondrial MAO-B using phenylethylamine as substrate assessed as substrate consumption at 100 nM preincubated for 30 mins measured up to 420 mins | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1506092 | Cognitive enhancing effect in Balb/c mouse assessed as protection against amyloid beta (1 to 42) oligomers-induced memory damage at 1 to 10 mg/kg, po qd via gavage for 17 days starting from 24 hrs post amyloid beta (1 to 42) oligomer treatment measured on | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1540197 | Inhibition of human histamine H3 receptor | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
| AID635888 | Inhibition of human AChE-induced amyloid beta (1 to 40) aggregation at 100 uM measured every 10 mins for 10 hrs by thioflavin T-based fluorometric analysis | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1545347 | Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins followed by substrate addition by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID1555513 | Inhibition of beta amyloid (unknown origin) self-induced aggregation at 10 uM relative to control | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID1540203 | Inhibition of human MAOB | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
| AID635870 | Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635873 | Ratio of donepezil IC50 to compound IC50 for equine serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635877 | Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation counting | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1421464 | Inhibition of rat liver mitochondrial MAOB using [14C]-PEA as substrate preincubated for 30 mins followed by substrate addition measured after 2 mins by liquid scintillation counting analysis | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. |
| AID635875 | Inhibition of human serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635886 | Non-competitive inhibition of rat liver mitochondrial MAO-B using phenylethylamine as substrate by Line-Weaver Burk plot analysis | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1421466 | Inhibition of BuChE (unknown origin) | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. |
| AID1506091 | In vivo antagonist activity at sigma1 receptor in sc dosed capsaicin-induced mechanical allodynia CD-1 mouse model assessed as increase in paw withdrawal latency pretreated for 30 mins followed by capsaicin treatment measured after 2 hrs | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1540204 | Inhibition of human BChE | 2019 | European journal of medicinal chemistry, Oct-15, Volume: 180 | Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
| AID1555511 | Inhibition of rat liver mitochondrial MAOA [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition by liquid scintillation counting analysis | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID1656489 | Inhibition of human MAO B | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| AID1555514 | Inhibition of AChE (unknown origin)-induced beta amyloid (unknown origin) aggregation at 100 uM relative to control | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID1545351 | Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins followed by substrate addition by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID635872 | Selectivity ratio of IC50 for equine serum BuchE to IC50 for Electrophorus electricus AchE | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1421463 | Inhibition of rat liver mitochondrial MAOA using [14C]-5-HT as substrate preincubated for 30 mins followed by substrate addition measured after 10 mins by liquid scintillation counting analysis | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. |
| AID1195740 | Inhibition of human MAO-A expressed in baculovirus infected BTI insect cells preincubated for 15 mins | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID635887 | Inhibition of self-induced amyloid beta (1 to 42) aggregation at 10 uM measured every 10 mins for 10 hrs by thioflavin T-based fluorometric analysis | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1555507 | Inhibition of AChE (unknown origin) | 2019 | European journal of medicinal chemistry, Aug-15, Volume: 176 | Multi-target design strategies for the improved treatment of Alzheimer's disease. |
| AID635820 | Irreversible inhibition of rat liver mitochondrial MAO-A using 5-hydroxytryptamine as substrate at 6 nM preincubated for 30 mins measured after three consecutive centrifugation | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID635879 | Selectivity ratio of IC50 for rat liver mitochondrial MAO-B to IC50 for rat liver mitochondrial MAO-A | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1076172 | Inhibition of human recombinant MAO-B using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1506087 | Displacement of [3H]DTG from sigma2 receptor in rat liver membranes after 60 mins by liquid scintillation counting method | 2018 | Journal of medicinal chemistry, Aug-09, Volume: 61, Issue:15
| Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile. |
| AID1076177 | Selectivity ratio of IC50 for human recombinant MAO-B to IC50 for human recombinant MAO-A | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1545346 | Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID1421465 | Inhibition of AChE (unknown origin) | 2018 | European journal of medicinal chemistry, Oct-05, Volume: 158 | Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. |
| AID635881 | Time-dependent inhibition of rat liver mitochondrial MAO-A using 5-hydroxytryptamine at 6 nM by scintillation counting | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1076173 | Inhibition of human recombinant MAO-A using tyramine as substrate preincubated for 30 mins followed by substrate addition measured for 1 hr by fluorometric assay | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1076176 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method | 2014 | European journal of medicinal chemistry, Mar-21, Volume: 75 | Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. |
| AID1195743 | Inhibition of recombinant human BuChE expressed in HEK293 cells preincubated for 15 mins | 2014 | Journal of medicinal chemistry, Dec-26, Volume: 57, Issue:24
| N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor. |
| AID1545345 | Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate by Amplex red reagent/horseradish peroxidase coupled fluorescence assay | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID635871 | Inhibition of equine serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method | 2011 | Journal of medicinal chemistry, Dec-22, Volume: 54, Issue:24
| Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di |
| AID1656488 | Inhibition of human MAO A | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |