Compounds > 1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine
Page last updated: 2024-09-25

1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine

Description

1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID130609
CHEMBL ID51737
SCHEMBL ID1521832
MeSH IDM0151718

Synonyms (14)

Synonym
NCI60_029911
1-methyl-4-(1-methylpyrrol-2-yl)-3,6-dihydro-2h-pyridine
1-methyl-4-(1-methyl-1h-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine oxalate
CHEMBL51737
1-methyl-4-(methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine
1,2,3,6-tetrahydro-1-methyl-4-(methylpyrrol-2-yl)pyridine
109835-15-6
pyridine, 1,2,3,6-tetrahydro-1-methyl-4-(1-methyl-1h-pyrrol-2-yl)-
1,2,3,6-tmmp
bdbm11019
1-methyl-4-(1-methyl-1h-pyrrol-2-yl)-1,2,3,6-tetrahydropyridine
1-methyl-4-(1-methylpyrrol-2-yl)-1,2,3,6-tetrahydropyridine
SCHEMBL1521832
DTXSID50911374

Protein Targets (1)

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Molecular Functions (3)

Processvia Protein(s)Taxonomy
primary amine oxidase activityAmine oxidase [flavin-containing] BBos taurus (cattle)
aliphatic amine oxidase activityAmine oxidase [flavin-containing] BBos taurus (cattle)
monoamine oxidase activityAmine oxidase [flavin-containing] BBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
mitochondrionAmine oxidase [flavin-containing] BBos taurus (cattle)
mitochondrial outer membraneAmine oxidase [flavin-containing] BBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID229784Ratio of Kcat versus Km was determined1999Journal of medicinal chemistry, May-20, Volume: 42, Issue:10
Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives.
AID488084Activity at baboon liver mitochondrial MAO-B assessed as H2O2 production at 250 uM after 6 to 15 mins pretreated with (R)-deprenyl2010Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.
AID127348Binding affinity towards monoaminooxidase Relative to MPTP1993Journal of medicinal chemistry, Oct-01, Volume: 36, Issue:20
QSAR's from similarity matrices. Technique validation and application in the comparison of different similarity evaluation methods.
AID126503Kcat against bovine liver Monoamine oxidase B1999Journal of medicinal chemistry, May-20, Volume: 42, Issue:10
Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives.
AID126515Km against bovine liver Monoamine oxidase B1999Journal of medicinal chemistry, May-20, Volume: 42, Issue:10
Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives.
AID488095Activity at baboon liver mitochondrial MAO-B assessed as initial rate of H2O2 production after 10 mins2010Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.
AID19439Partition coefficient (logP)1999Journal of medicinal chemistry, May-20, Volume: 42, Issue:10
Studies on the monoamine oxidase-B-catalyzed biotransformation of 4-azaaryl-1-methyl-1,2,3,6-tetrahydropyridine derivatives.
AID488096Ratio of Vmax to Km for baboon liver mitochondrial MAO-B assessed per mg of protein after 10 mins2010Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.
AID488094Activity at baboon liver mitochondrial MAO-B assessed as initial rate of H2O2 production after 10 mins assessed per mg of mitochondrial protein2010Bioorganic & medicinal chemistry, Jun-01, Volume: 18, Issue:11
Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (37.50)18.7374
1990's4 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
4-hydroxybenzoic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
plant metabolite
benzoic acid[no description available]medium10benzoic acidsalgal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite
3-chlorobenzoic acid[no description available]medium10monochlorobenzoic aciddrug metabolite
4-aminobenzoic acid[no description available]medium10aminobenzoic acid;
aromatic amino-acid zwitterion		allergen;
Escherichia coli metabolite;
plant metabolite
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine[no description available]medium50methylpyridines;
phenylpyridine;
tetrahydropyridine		neurotoxin
clonidine[no description available]medium10clonidine;
imidazoline
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
etiocholanolone[no description available]medium1017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid		human metabolite;
mouse metabolite
dehydroepiandrosterone[no description available]medium1017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
4-nitrobenzoic acid[no description available]medium10nitrobenzoic acid
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
desoxycorticosterone[no description available]medium1020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
17-alpha-hydroxyprogesterone[no description available]medium1017alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
tertiary alpha-hydroxy ketone		human metabolite;
metabolite;
mouse metabolite;
progestin
4-chlorobenzoic acid[no description available]medium10monochlorobenzoic acidbacterial xenobiotic metabolite
4-tert-butylbenzoic acid[no description available]medium10alkylbenzene
3-toluic acid[no description available]medium10methylbenzoic acidhuman xenobiotic metabolite
3-aminobenzoic acid[no description available]medium10aminobenzoic acid
3-hydroxybenzoic acid[no description available]medium10monohydroxybenzoic acidbacterial metabolite;
plant metabolite
4-toluic acid[no description available]medium10methylbenzoic acid
4-anisic acid[no description available]medium10methoxybenzoic acidplant metabolite
3-nitrobenzoic acid[no description available]medium10
pregnenolone[no description available]medium1020-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid		human metabolite;
mouse metabolite
4-(trifluoromethyl)benzoic acid[no description available]medium10(trifluoromethyl)benzenes;
benzoic acids
3-fluorobenzoic acid[no description available]medium10fluorobenzoic acid
4-fluorobenzoic acid[no description available]medium10fluorobenzoic acidbacterial xenobiotic metabolite
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
3-methoxybenzoic acid[no description available]medium10methoxybenzoic acidflavouring agent;
human urinary metabolite
4-bromobenzoic acid[no description available]medium10bromobenzoic acid
3-iodobenzoate[no description available]medium10iodobenzoic acid
4-ethylbenzoic acid[no description available]medium10benzoic acids
4-cyanobenzoic acid[no description available]medium10
st 91[no description available]medium10substituted aniline
norharman[no description available]medium10beta-carbolines;
mancude organic heterotricyclic parent		fungal metabolite;
marine metabolite
4-(fluorosulfonyl)benzoic acid[no description available]medium10
tiazuril[no description available]medium10aryl sulfide
2-(2-methyl-4-chlorophenylamino)-2-imidazoline[no description available]medium10
xylonidine[no description available]medium10
1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine[no description available]medium10
4-phenyl-1,2,3,6-tetrahydropyridine[no description available]medium10
4-(methylthio)benzoic acid[no description available]medium10
17-alpha-hydroxypregnenolone[no description available]medium1017alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid;
hydroxypregnenolone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine[no description available]medium10
4-mercaptobenzoate[no description available]medium10
2,5-dihydro-2-(4-methoxyphenyl)-3h-pyrazolo(4,3-c)quinolin-3-one[no description available]medium10
beta-carboline-3-carboxylic acid ethyl ester[no description available]medium10beta-carbolines
beta-carboline-3-carboxylic acid methyl ester[no description available]medium10beta-carbolines
2-methyltryptoline[no description available]medium10beta-carbolines
3-ethoxy-beta-carboline[no description available]medium10
tert-butyl beta-carboline-3-carboxylate[no description available]medium10
1-methyl-4-cyclohexyl-1,2,3,6-tetrahydropyridine[no description available]medium10
1-methyl-4-(2'-ethylphenyl)-1,2,3,6-tetrahydropyridine[no description available]medium10
4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine[no description available]medium10
n-propyl-4-phenyl-1,2,3,6-tetrahydropyridine[no description available]medium10
cortisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cortodoxone[no description available]medium10deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
diclazuril[no description available]medium10nitrile
3-propoxy-beta-carboline[no description available]medium10
harman[no description available]medium10harmala alkaloid;
indole alkaloid fundamental parent;
indole alkaloid		anti-HIV agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite
1-Ethyl-9H-pyrido[3,4-b]indole[no description available]medium10harmala alkaloid
benzylamine[no description available]medium10aralkylamine;
primary amine		allergen;
EC 3.5.5.1 (nitrilase) inhibitor;
plant metabolite
kynuramine[no description available]medium10kynurenamines;
primary amino compound		metabolite
retinaldehyde[no description available]medium10retinal;
vitamin A		gap junctional intercellular communication inhibitor;
human metabolite;
mouse metabolite
piperidines[no description available]medium20
3,4-dihydroxyphenylacetic acid[no description available]medium10catechols;
dihydroxyphenylacetic acid		human metabolite
homovanillic acid[no description available]medium10guaiacols;
monocarboxylic acid		human metabolite;
mouse metabolite
tretinoin[no description available]medium10retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
methyldimethylaminoazobenzene[no description available]medium10
(2e,4e,6e,10e)-3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Encephalopathy, Toxic0low10
Experimental Hepatoma0low10
Experimental Hepatomas0low10
Experimental Liver Neoplasms0low10
Hepatoma, Experimental0low10
Hepatoma, Morris0low10
Hepatoma, Novikoff0low10
Hepatomas, Experimental0low10
Liver Neoplasms, Experimental0low10
Neoplasms, Experimental Liver0low10
Nervous System Poisoning0low10
Neurotoxic Disorders0low10
Neurotoxicity Syndromes0low10
Neurotoxin Diseases0low10
Neurotoxin Disorders0low10
Poisoning, Nervous System0low10
Pregnancy0low10
Toxic Encephalitis0low10