Fenazaquin is a synthetic acaricide, belonging to the pyrazole group of insecticides, that is used to control a wide range of mites and ticks. It acts as an inhibitor of mitochondrial respiration, interfering with the electron transport chain in the mitochondria of insects. This disrupts their energy production, leading to paralysis and death. Fenazaquin is effective against both mobile and quiescent stages of mites and ticks, and is used in various agricultural applications, including fruit trees, vegetables, and ornamental plants. Research into fenazaquin focuses on its efficacy, mode of action, environmental fate, and potential effects on non-target organisms. Its selective toxicity to mites and ticks, compared to other organisms, makes it a valuable tool for pest control. However, its potential environmental impact and resistance development are areas of ongoing research.'
fenazaquin: an experimental miticide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 86356 |
| CHEMBL ID | 243282 |
| CHEBI ID | 38593 |
| SCHEMBL ID | 26216 |
| MeSH ID | M0232648 |
| Synonym |
|---|
| 4-((4-(1,1-dimethylethyl)phenyl)ethoxy)quinazoline |
| quinazoline, 4-((4-(1,1-dimethylethyl)phenyl)ethoxy)- |
| fenazaquin [iso] |
| 120928-09-8 |
| 4-[2-(4-tert-butylphenyl)ethoxy]quinazoline |
| fenazaquin |
| CHEBI:38593 , |
| 4-tert-butylphenethylquinazolin-4-yl ether |
| fenazaquine |
| CHEMBL243282 |
| C18727 |
| fenazachin |
| pride ultra |
| gwn 1708 |
| hsdb 7948 |
| magus |
| fenaza |
| dk5q534wee , |
| 4-(2-(4-(1,1-dimethylethyl)phenyl)ethoxy)quinazoline |
| ec 410-580-0 |
| unii-dk5q534wee |
| quinazoline, 4-(2-(4-(1,1-dimethylethyl)phenyl)ethoxy)- |
| xde 436 |
| el 436 |
| dtxcid2020476 |
| dtxsid4040476 , |
| tox21_301223 |
| cas-120928-09-8 |
| NCGC00255594-01 |
| FT-0631103 |
| AKOS015903772 |
| el-436 |
| de-436 |
| 4-(2-(4-(tert-butyl)phenyl)ethoxy)quinazoline |
| fenazaquin [mi] |
| 4-tert-butylphenethyl quinazolin-4-yl ether |
| SCHEMBL26216 |
| 4-[2-[4-(t-butyl)phenyl]ethoxy]quinazoline |
| KS-5370 |
| 4-(4-(tert-butyl)phenethoxy)quinazoline |
| xde436 |
| J-004412 |
| fenazaquin, pestanal(r), analytical standard |
| fenazaquin 100 microg/ml in cyclohexane |
| fenazaquin 10 microg/ml in cyclohexane |
| fenazaquin 10 microg/ml in acetonitrile |
| 4-(4-tert-butylphenethoxy)quinazoline |
| mfcd01656049 |
| Q1404580 |
| D94877 |
| A906814 |
| xde-436 |
| el436 |
| CS-0065863 |
Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea. Fenazaquin (I) is a new acaricides of the quinazoline class.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Fenazaquin (I) is a new acaricide of the quinazoline class. " | ( Photodecomposition of an acaricide, fenazaquin, in aqueous alcoholic solution. Banerjee, H; Bhattacharyya, A; Bhattacharyya, J, 2003) | 2.04 |
| "Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea. " | ( Investigation in tea on fate of fenazaquin residue and its transfer in brew. Desikachar Ravindranath, S; Kumar Tewary, D; Kumar, V; Shanker, A, 2004) | 2.05 |
| "Fenazaquin is a non-systemic acaricide/insecticide used widely in controlling mites and other related pests in fruits, vegetables and tea. " | ( Investigation in tea on fate of fenazaquin residue and its transfer in brew. Kumar, V; Ravindranath, SD; Shanker, A; Tewary, DK, 2006) | 2.06 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The compounds were tested at their respective maximum field recommended concentration (MFRC), and, when strong lethal effects were observed, a dose-response assay with a dilution series of the MFRC was undertaken to calculate LC(50) values." | ( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010) | 0.36 |
| " For oral exposures via treated sugar water, the dose-response assay showed the LC(50) values for abamectin, bifenazate, bifenthrin and etoxazole to be 1/15 MFRC (1." | ( Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. Besard, L; Cuvelier, X; Mommaerts, V; Smagghe, G; Sterk, G; Vandeven, J, 2010) | 0.36 |
| " The results demonstrate that the xenobiotic metabolism conferred by transfection of CYP-encoding mRNAs shifts the dose-response relationship for some of the tested chemicals such as aflatoxin B1 (bioactivation) and fenazaquin (detoxification)." | ( mRNA transfection retrofits cell-based assays with xenobiotic metabolism. Carmichael, PL; DeGroot, DE; Lee, MY; Simmons, SO; Strynar, M; Swank, A; Thomas, RS, ) | 0.32 |
| Role | Description |
|---|---|
| acaricide | A substance used to destroy pests of the subclass Acari (mites and ticks). |
| mitochondrial NADH:ubiquinone reductase inhibitor | null |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| quinazolines | Any organic heterobicyclic compound based on a quinazoline skeleton and its substituted derivatives. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID297626 | Inhibition of bovine mitochondrial MC1 | 2007 | Journal of medicinal chemistry, Sep-06, Volume: 50, Issue:18 | Synthesis and biological evaluation of the mitochondrial complex 1 inhibitor 2-[4-(4-fluorobutyl)benzylsulfanyl]-3-methylchromene-4-one as a potential cardiac positron emission tomography tracer. |
| AID1104350 | Contact toxicity against Bombus terrestris (bumblebee) assessed per bee | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104469 | Contact toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 200 mg a.i./l applied on the dorsal thorax for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104367 | Toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 200 mg a.i./l, po administered through pollen for 11 weeks measured once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104452 | Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 200 mg a.i./l, po administered through sugar water for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID308798 | Inhibition of MC1 by NADH-DB reductase assay | 2007 | Bioorganic & medicinal chemistry letters, Sep-01, Volume: 17, Issue:17 | Quinazoline derivatives as MC-I inhibitors: evaluation of myocardial uptake using Positron Emission Tomography in rat and non-human primate. |
| AID1104349 | Contact toxicity against Apis mellifera (honey bee) assessed per bee | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID1104398 | Contact toxicity against worker Bombus terrestris (bumblebee) assessed as reduction in reproduction at 200 mg a.i./l applied on the dorsal thorax for 11 weeks measured once a week for 11 weeks relative to control | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| AID407933 | Inhibition of mitochondrial complex 1 in bovine heart mitochondria assessed as effect on rate of NADH oxidation | 2008 | Journal of medicinal chemistry, May-22, Volume: 51, Issue:10 | Synthesis and biological evaluation of pyridazinone analogues as potential cardiac positron emission tomography tracers. |
| AID1104421 | Toxicity against worker Bombus terrestris (bumblebee) assessed as mortality at 200 mg a.i./l, po administered through pollen for 11 weeks measured everyday for 3 days followed by once a week for 11 weeks | 2010 | Pest management science, Jul, Volume: 66, Issue:7 | Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 4 (19.05) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (41.05) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 22 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||