clotrimazole has been researched along with Otomycosis in 10 studies
Otomycosis: Fungus infection of the external ear, usually by ASPERGILLUS species
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the clinical effectiveness and adverse events for 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in the treatment of otomycosis." | 9.22 | Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial. ( Romsaithong, S; Tangsawad, W; Thanaviratananich, S; Tomanakan, K, 2016) |
| ", Montreal, Quebec, Canada) and clotrimazole in the treatment of patients with otomycosis." | 8.93 | A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( Bonaparte, JP; Herasym, K; Kilty, S, 2016) |
| "Treatment with clotrimazole 1% solution groups resulted in 88." | 7.01 | Efficacy of Clotrimazole 1% Solution Compared to Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% Cream in Patient with Otomycosis. ( Ahmed, MB; Ahmed, S; Alam, MM; Islam, MR; Khan, L; Mostafa, MG; Rahman, MA, 2021) |
| "Otomycosis is one of the relatively common diseases in the world which is caused by different fungi especially saprophytes." | 5.51 | Role of Clotrimazole in Prevention of Recurrent Otomycosis. ( Karami, M; Kiakojuri, K; Mahdavi Omran, S; Pournajaf, A; Rajabnia, R; Taghizadeh Armaki, M, 2019) |
| " The evidence is very uncertain about the effect of clotrimazole on clinical resolution of otomycosis, on significant adverse events or other (non-serious) adverse events when compared with other topical azoles (eberconazole, fluconazole, miconazole)." | 5.12 | Topical azole treatments for otomycosis. ( Lee, A; Saeed, SR; Tysome, JR, 2021) |
| ", Montreal, Quebec, Canada) and clotrimazole in the treatment of patients with otomycosis." | 4.93 | A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis. ( Bonaparte, JP; Herasym, K; Kilty, S, 2016) |
| "Local antifungal agents clotrimazole, 3% salicylic acid and 10% povidone iodine were effective in the treatment of otomycosis with varying degrees of success, with clotrimazole being the most effective." | 4.02 | Various topical antifungal agents in otomycosis, which is the best? ( Jwery, AK, 2021) |
| "However, sometime it is difficult to treat otomycosis along with mastoid cavity, chronic suppurative otitis media, immunocompromised patient, etc." | 2.87 | Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis - Our experiences at a tertiary care teaching hospital of eastern India. ( Behera, IC; Das, A; Sahu, MC; Swain, SK, 2018) |
| "Otomycosis is one of the relatively common diseases in the world which is caused by different fungi especially saprophytes." | 1.51 | Role of Clotrimazole in Prevention of Recurrent Otomycosis. ( Karami, M; Kiakojuri, K; Mahdavi Omran, S; Pournajaf, A; Rajabnia, R; Taghizadeh Armaki, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (70.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jwery, AK | 1 |
| Kiakojuri, K | 1 |
| Rajabnia, R | 1 |
| Mahdavi Omran, S | 1 |
| Pournajaf, A | 1 |
| Karami, M | 1 |
| Taghizadeh Armaki, M | 1 |
| Lee, A | 1 |
| Tysome, JR | 1 |
| Saeed, SR | 1 |
| Mostafa, MG | 1 |
| Ahmed, S | 1 |
| Islam, MR | 1 |
| Rahman, MA | 1 |
| Khan, L | 1 |
| Alam, MM | 1 |
| Ahmed, MB | 1 |
| Swain, SK | 1 |
| Behera, IC | 1 |
| Sahu, MC | 1 |
| Das, A | 1 |
| Kamali Sarwestani, Z | 1 |
| Hashemi, SJ | 1 |
| Rezaie, S | 1 |
| Gerami Shoar, M | 1 |
| Mahmoudi, S | 1 |
| Elahi, M | 1 |
| Bahardoost, M | 1 |
| Tajdini, A | 1 |
| Abutalebian, S | 1 |
| Daie Ghazvini, R | 1 |
| Herasym, K | 1 |
| Bonaparte, JP | 1 |
| Kilty, S | 1 |
| Romsaithong, S | 1 |
| Tomanakan, K | 1 |
| Tangsawad, W | 1 |
| Thanaviratananich, S | 1 |
| Viswanatha, B | 1 |
| Sumatha, D | 1 |
| Vijayashree, MS | 1 |
| Block, TK | 1 |
| Munson, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase III, Multicenter, Randomized, Double-blind, Parallel Group, Active Treatment-controlled Study Assessing the Safety and Efficacy of G238 Compared to Clotrimazole 1% Otic Solution in Patients With Otomycosis[NCT01993823] | Phase 3 | 190 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The secondary efficacy variables include:~Proportion of subjects with signs and symptoms score of 0 at Day 15~Proportion of subjects with signs and symptoms score of 0 at Day 24~Proportion of subjects with a negative culture for fungus or presumed eradication (mycological cure) on Day 24." (NCT01993823)
Timeframe: 2 weeks and 4 weeks
| Intervention | percentage of patient (Number) | ||
|---|---|---|---|
| Signs and symptoms score 0 at Day 15 | Signs and symptoms score 0 at Day 24 | Mycological cure at Day 24 | |
| Clotrimazole | 77.65 | 86.08 | 97.65 |
| G238 | 59.55 | 85.83 | 96.63 |
"Efficacy will be assessed primarily by evaluation of the fungal culture, and the sum of signs and symptom scores (pruritus, otalgia, otorrhea and aural fullness obstruction to be scored as 0=absent; 1= mild; 2=moderate; 3=severe). The primary efficacy variable is the proportion of subjects with a negative culture for fungus, AND a signs and symptom score of 0 on Day 24.~Response to the study treatment was classed according to the following definitions:~Complete response: Negative fungal culture or presumed eradication on day 24, and sum score for signs and symptoms = 0 on day 24.~Partial response: Negative culture or presumed eradication on day 24, and sum score for signs and symptoms = 1 or 2 on day 24.~No response: Positive culture on day 24 or negative culture or presumed eradication and sum score for signs and symptoms > 2 on day 24." (NCT01993823)
Timeframe: Day 24
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Complete Response | Partial Response | No-response | Missing data | |
| Clotrimazole | 66 | 11 | 2 | 6 |
| G238 | 72 | 11 | 5 | 1 |
3 reviews available for clotrimazole and Otomycosis
| Article | Year |
|---|---|
Topical azole treatments for otomycosis.
Topics: Administration, Topical; Adult; Antifungal Agents; Bias; Child; Clotrimazole; Cycloheptanes; Flucona | 2021 |
A comparison of Locacorten-Vioform and clotrimazole in otomycosis: A systematic review and one-way meta-analysis.
Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Candidiasis; Child; Clioqu | 2016 |
Otomycosis in immunocompetent and immunocompromised patients: comparative study and literature review.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillus; Candida albicans; Clotrimazole; Female; Hum | 2012 |
3 trials available for clotrimazole and Otomycosis
| Article | Year |
|---|---|
Efficacy of Clotrimazole 1% Solution Compared to Econazole Nitrate 1% + Triamcinolone Acetonide 0.1% Cream in Patient with Otomycosis.
Topics: Administration, Topical; Antifungal Agents; Bangladesh; Clotrimazole; Econazole; Humans; Otomycosis; | 2021 |
Povidone iodine soaked gelfoam for the treatment of recalcitrant otomycosis - Our experiences at a tertiary care teaching hospital of eastern India.
Topics: Administration, Topical; Adolescent; Adult; Aged; Antifungal Agents; Clotrimazole; Female; Gelatin S | 2018 |
Effectiveness of 3 per cent boric acid in 70 per cent alcohol versus 1 per cent clotrimazole solution in otomycosis patients: a randomised, controlled trial.
Topics: Adult; Antifungal Agents; Boric Acids; Clotrimazole; Ear Canal; Female; Humans; Instillation, Drug; | 2016 |
4 other studies available for clotrimazole and Otomycosis
| Article | Year |
|---|---|
Various topical antifungal agents in otomycosis, which is the best?
Topics: Adult; Antifungal Agents; Clotrimazole; Female; Humans; Male; Otomycosis; Prospective Studies; Singl | 2021 |
Role of Clotrimazole in Prevention of Recurrent Otomycosis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifungal Agents; Aspergillosis; Aspergillus niger; Can | 2019 |
Species identification and in vitro antifungal susceptibility testing of Aspergillus section Nigri strains isolated from otomycosis patients.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Aspergillosis; Aspergillus niger; Clotrimazole; Female; | 2018 |
A 19-year-old male with a 3-day history of congestion and ear pain.
Topics: Antifungal Agents; Aspergillosis; Aspergillus niger; Clotrimazole; Ear; Humans; Male; Otomycosis; Pa | 2012 |